Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 17, Problem 63TQ
Summary Introduction
To review:
The explanation for the resistance of the histone cores to the hydrolytic actions of the nucleases.
Introduction:
DNA or deoxyribonucleic acid comprises 2 polydeoxynucleotidestrands, which are wrapped around one another in the form of the right-handed double helix. The structure of the DNA is known to be distinctive and hence, it is also referred to as double helix.
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QUESTION NO. 1
Patients with the rare genetic disease xeroderma pigmentosum (XP) are very sensitive to light and are highly susceptible to skin cancers. The study of such patients has enhanced our knowledge of DNA repair because XP is caused by defective DNA repair nucleotide excision repair. (A variant, XP-V, is deficient in postreplication repair.) In nucleotide excision repair
A. removal of the damaged bases occurs on only one strand of the DNA.
B. only thymine dimers generated by UV light can be removed .
C. the excision nuclease is an exonuclease.
D. a single multifunctional enzyme carries out the repair process.
E. only the damaged nucleotides are removed.
QUESTION NO.2
Homologous recombination:
A. occurs only between two segments from the same DNA molecule.
B. requires that a specific DNA sequence be present.
C. requires one of the duplexes undergoing recombination be nicked in both strands.
D. involves a…
Four basic properties of the genetic code are specificity, degenerate, almost universal, and _____________.
Question 1.
Enzymes, proteins and deoxyribonucleic acid (DNA)
macromolecules. Enzymes are not only speed up the reaction, but also are necessary for DNA
repreduction.
are important biological
a) Compare the process of protein synthesis between eukaryote mRNA and viral RNA
b) With the aid of a diagram, draw an adapter molecule that recognizes the codons of mRNA
and explain its functions in DNA translation.
Chapter 17 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 17 - Prob. 1QCh. 17 - Prob. 2QCh. 17 - Prob. 3QCh. 17 - Prob. 4QCh. 17 - Prob. 5QCh. 17 - Prob. 6QCh. 17 - Prob. 7QCh. 17 - Prob. 8QCh. 17 - Prob. 1RQCh. 17 - Prob. 2RQ
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- The _____________ is the term used for polypeptide destruction motifs.arrow_forwardExpressed sequences of DNA are called ________________.arrow_forwardQUESTION 8 Consider the pathway for the synthesis of the amino acid arginine in Neurospora: ARG-E → citrulline ARG-F ARG-H ornithine argininosuccinate arginine Mutant strains of Neurospora may carry one or more mutations. Neurospora mutant strain b is grown on minimal media plus supplements as shown. Growth is shown by (+) and no growth is shown by (o). Supplements ornithine mutant nothing citrulline arginino- succinate arginine strain What can you conclude from these data? O Strain a has only one mutation and it is in ARG-E. O Strain b has only one mutation and it is in ARG-H. O Strain a has a mutation in ARG-F and strain b has a mutation in ARG-E. O Strain b has mutations in ARG-E, ARG-F, and ARG-H. + +arrow_forward
- When nitrogenous bases in single-stranded polynucleotides are incorporated into doublestranded molecules, base pair formation results in altered UV light absorption. This is called the _____________ effectarrow_forwardAn enzyme called _____________________ catalyzes theformation of a covalent phosphodiester bond between the 3′OH end of one DNA strand and the 5′ phosphate end of anadjacent strand during DNA replication.arrow_forwardA _____________ is a multienzyme complex that synthesizes RNA primers in E. coli DNA replication.arrow_forward
- The purpose of mitosis in human cells is for the production of two diploid, _________________ cells.arrow_forwardA base change that has no discernible effect is called a____________________ mutation.arrow_forwardQuestion 7: Peptide nucleic acids (PNAS) exhibit greater stability as heteroduplexes with DNA (ie PNA-DNA duplex) than does double-stranded DNA (i.e. DNA-DNA duplex). However, peptide nucleic acids lack charged groups, making them largely insoluble under near-physiological conditions in aqueous buffer. Provide (1) an explanation for the increased stability of PNA-DNA duplexes (hint: consider intermolecular forces). (2) Additionally, propose modification(s) of the PNA scaffold DNA that could increase solubility without drastically reducing duplex stability. PNA R1 HN но. Base Base o=P-O NH Base Base 8 o=P-O- NH 8. Base Base НО NHarrow_forward
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