Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 17, Problem 3RQ
Summary Introduction

To review:

The definition of the following terms:

1. Point mutation.

2. Transition mutation.

3. Transversion mutation.

4. Silent mutation.

5. Missense mutation.

Introduction:

Mutations refer to the random alterations of the nucleotide-base sequence of the genome. These alterations can be caused by different agents or can occur due to spontaneous reasons; they are typically permanent in nature. A mutation not only changes the nucleotidebase sequence but also affects the overall gene expression. Based on the extent and nature of the change produced, mutations are classified into point, transition, transversion, silent, and missense mutations.

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Question 1. Enzymes, proteins and deoxyribonucleic acid (DNA) macromolecules. Enzymes are not only speed up the reaction, but also are necessary for DNA repreduction. are important biological a) Compare the process of protein synthesis between eukaryote mRNA and viral RNA b) With the aid of a diagram, draw an adapter molecule that recognizes the codons of mRNA and explain its functions in DNA translation.
If Adenine was added where Guanine should have been added, this would be an example of a ___________________ mutation.
QUESTION NO. 1  Patients with the rare genetic disease xeroderma pigmentosum (XP) are very sensitive to light and are highly susceptible to skin cancers. The study of such patients has enhanced our knowledge of DNA repair because XP is caused by defective DNA repair nucleotide excision repair. (A variant, XP-V, is deficient in postreplication repair.) In nucleotide excision repair A. removal of the damaged bases occurs on only one strand of the DNA. B. only thymine dimers generated by UV light can be removed . C. the excision nuclease is an exonuclease. D. a single multifunctional enzyme carries out the repair process. E. only the damaged nucleotides are removed. QUESTION NO.2  Homologous recombination:  A. occurs only between two segments from the same DNA molecule. B. requires that a specific DNA sequence be present. C. requires one of the duplexes undergoing recombination be nicked in          both strands. D. involves a…

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Biochemistry: The Molecular Basis of Life

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