Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 17, Problem 53SA
Summary Introduction
To review:
The elimination of the effects of BPA in Avy offspring when their parents were fed with methyl donor-richdiet.
Introduction:
It was observed that when mice with agouti coatcolorweresupplemented with bisphenolA (BPA), the coatcolor of the offspring shifted from brown to yellow. BPA is responsible for epigenetic changes that do not alter gene sequence but alters the gene expression rate. When BPAsupplemented mice were provided with methyl donors (foliate, choline and vitamin B12) in their lab chow, the effects of BPA (bisphenol A) were eliminated. The offspring produced from such mice tended to havebrown-colored coats again.
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Chapter 17 Solutions
Biochemistry: The Molecular Basis of Life
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