Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 17, Problem 36RQ
Summary Introduction
To review:
The histone code hypothesis of the deoxyribonucleic acid (DNA).
Introduction:
A hypothesis is a term given to an idea with limited evidence, havinga scope for further experiments. The histones can be defined as a family of basic proteins, which are associated with DNA in the nucleus. They help in the condensation of DNA into chromatin. The nuclear DNA is found as a mesh of DNA strands. It is highly condensed and wrapped around histones. It is done so that the DNA fits inside of the nucleus and participate in the formation of chromosomes.
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Expressed sequences of DNA are called ________________.
Noncoding DNA sequences are called __________________.
QUESTION NO. 1
Patients with the rare genetic disease xeroderma pigmentosum (XP) are very sensitive to light and are highly susceptible to skin cancers. The study of such patients has enhanced our knowledge of DNA repair because XP is caused by defective DNA repair nucleotide excision repair. (A variant, XP-V, is deficient in postreplication repair.) In nucleotide excision repair
A. removal of the damaged bases occurs on only one strand of the DNA.
B. only thymine dimers generated by UV light can be removed .
C. the excision nuclease is an exonuclease.
D. a single multifunctional enzyme carries out the repair process.
E. only the damaged nucleotides are removed.
QUESTION NO.2
Homologous recombination:
A. occurs only between two segments from the same DNA molecule.
B. requires that a specific DNA sequence be present.
C. requires one of the duplexes undergoing recombination be nicked in both strands.
D. involves a…
Chapter 17 Solutions
Biochemistry: The Molecular Basis of Life
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- Question 1. Enzymes, proteins and deoxyribonucleic acid (DNA) macromolecules. Enzymes are not only speed up the reaction, but also are necessary for DNA repreduction. are important biological a) Compare the process of protein synthesis between eukaryote mRNA and viral RNA b) With the aid of a diagram, draw an adapter molecule that recognizes the codons of mRNA and explain its functions in DNA translation.arrow_forwardA _____________ is a multienzyme complex that synthesizes RNA primers in E. coli DNA replication.arrow_forwardA base change that has no discernible effect is called a____________________ mutation.arrow_forward
- QUESTION 8 Consider the pathway for the synthesis of the amino acid arginine in Neurospora: ARG-E → citrulline ARG-F ARG-H ornithine argininosuccinate arginine Mutant strains of Neurospora may carry one or more mutations. Neurospora mutant strain b is grown on minimal media plus supplements as shown. Growth is shown by (+) and no growth is shown by (o). Supplements ornithine mutant nothing citrulline arginino- succinate arginine strain What can you conclude from these data? O Strain a has only one mutation and it is in ARG-E. O Strain b has only one mutation and it is in ARG-H. O Strain a has a mutation in ARG-F and strain b has a mutation in ARG-E. O Strain b has mutations in ARG-E, ARG-F, and ARG-H. + +arrow_forward. ___________________________ factors are proteins thatregulate or initiate RNA synthesis by binding directly orindirectly to specific DNA sequences called responseelements.arrow_forwardA _____________________ is a multienzyme complex thatsynthesizes RNA primers during E. coli DNA replication.arrow_forward
- Enzymes isolated from bacteria that cut DNA at specificsequences are called ____________________.arrow_forwardQuestion 6 The helical turns of the DNA does not only provide spaces for binding with regulatory proteins but they cause the molecule to resemble a spiral staircase. A) True B) Falsearrow_forwardQuestion 49 The Sanger method of DNA sequencing follows the principle of complementarity just like in the replication process. A) True B) Falsearrow_forward
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