Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 17, Problem 3Q
Summary Introduction

To review:

The harmful substances that cause oxidative damage to the body. Some tissues are able to sustain more oxidative damage than others are.

Introduction:

Oxidative damage means that free radicals areproduced in a large amount, and there is an imbalance between the free radicals and the antioxidants (substances that detoxify the harmfuleffects of free radicals) in the body. These free radicalsmay be produced by harmful ionizing radiations, for exampl, eltraviolet (UV), X-rays, and gamma( γ )-rays.

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A molecular researcher, Dr. Sidra Alkatini, is investigating the manifestation of a disorder in some of her lab mice models, which are lacking production of an important protein necessary for the cellular respiration pathway. The afflicted mice are short lived, and have perpetually low blood glucose levels, no matter how much food they are fed. Through sequencing, the following strand of DNA was produced:                    5’ TTC CAA TTA CGC CGC TAT ACG CGC ACC ATG TTA TCA TGT TGG TGG TAG 3’ Given your expertise in genetics, she contacts you, her BFF, to help her understand the sequence and its relation to the genetic disorder she is seeing.   1)  What motif in this DNA sequence would serve as the RBS?   a  Essentially none; this is a eukaryotic sequence, so the RBS will be made up of the methylated G-cap! b  CAAT! c ACCATGG! d TATA!   2)  Do you notice anything unusual about this transcript?   a YES! It is very short! b YES! It is…
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Biochemistry: The Molecular Basis of Life

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