Introduction to Genetic Analysis
Introduction to Genetic Analysis
11th Edition
ISBN: 9781464109485
Author: Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Publisher: W. H. Freeman
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Chapter 2, Problem 79P

a.

Summary Introduction

To determine: The unusual nature of the pedigree given in the question.

Introduction: The chart in which the pattern of disease can be shown by studying the genotypic pattern of the family is termed as the pedigree. The pedigree analysis shows the genotype of both the male and female.

b.

Summary Introduction

To determine: If the pattern can be used to explain the Mendelian inheritance.

Introduction: Mendelian inheritance shows the inheritance of different diseases differently. Some might have the possibility that the disease might be expressed in every generation whereas there are some diseases that are expressed after skipping some of the generations.

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Please answer all of them, they are all connected. PEDIGREE ANALYSIS and SYMBOLOGY: Examine the pedigree which has X linked Dominant inheritance of disorder. Use letter X* (asterisk denotes disorder) as genotype of the individuals which can be XX, XY, X*X*, X*X and X*Y. a. What is the genotype of IV-6? b. What is the genotype of III-6? c. What is the genotype of II-3? d. What is the genotype of III-8? e. If couple I-1 and I-2 will have a son, what is the probability of having the disorder? f. If couple III-8 and III-9 will have another child, what is the probability of having the disorder? g. Theoretically, if individual IV-3 and individual IV-5 will marry and will have a child, what is the probability of having a child without the X-linked disorder?
A couple who are about to get married learn from studying their family histories that, in both their families, theirunaffected grandparents had siblings with cystic fibrosis(a rare autosomal recessive disease).a. If the couple marries and has a child, what is theprobability that the child will have cystic fibrosis?b. If they have four children, what is the chance that thechildren will have the precise Mendelian ratio of 3:1 fornormal:cystic fibrosis?c. If their first child has cystic fibrosis, what is theprobability that their next three children will be normal?
17. Parents Jacob and Emma have had two children, Samuel and Matthew. Baby Samuel died at the age of nine days. When baby Matthew has trouble feeding, his parents take him in to the doctor. He is diagnosed with Maple Syrup Urine Disease (MSUD), a life-threatening condition in which the patient is not able to break down proteins from 19 their food. As Matthew receives treatment, Jacob and Emma are referred to a genetic counselor. The genetic counselor collects information about their family. Neither of Jacob's parents were affected by MSUD. Jacob had one brother and three sisters. One of these sisters died shortly after birth. Similarly, neither of Emma's parents were affected by MSUD. Emma had four brothers, and two of these died shortly after birth. a. Given what you know about Jacob and Emma's family, construct a pedigree that includes all three generations.

Chapter 2 Solutions

Introduction to Genetic Analysis

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