Introduction to Genetic Analysis
11th Edition
ISBN: 9781464109485
Author: Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Question
Chapter 2, Problem 77P
Summary Introduction
To determine: The inheritance pattern of the given pedigree chart.
Introduction: Different methods can be followed by different diseases to carry forward to the next generation. The inheritance pattern includes autosomal dominant, autosomal recessive, X-linked recessive, X-linked dominant, and Y-linked.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
The following pedigree shows the inheritance of a human disorder. Affected individuals are
shown with filled symbols.
II
III
2 3
5
Based on the pedigree, propose the least likely inheritance pattern of the disease among
autosomal dominance, autosomal recessive, X-linked dominance and X-linked recessive.
Your choice of answer can be impossible and possible. Explain your answer by giving the
evidence that supports or opposes each mode of inheritance. You can reconstruct the table
shown below and draw the pedigree in your answer script. Write the possible genotype of
each individual in the pedigree for each inheritance pattern proposed.
Mode of
Possibility
Explanations
Pedigree
inheritance
Autosomal
dominance
Autosomal
recessive
X-linked
dominance
X-linked
recessive
A woman knows that her mother is a carrier of Kartagener’s syndrome (an autosomal recessive disorder). The woman does not know if either she or her husband are carriers. The couple wants to have a child, but is worried about whether or not they could have a child with Kartagener’s syndrome. Should the couple seek the advice of a genetic counselor? In other words, is there a chance they could have an affected child? If there is a chance, please make sure your answer includes the specific parental genotypes necessary to make this possible.
7) The pedigree below traces the inheritance of alkaptonuria, a biochemical disorder. Does
alkaptonuria appear to be caused by a dominant or recessive allele? Is this allele autosomal or sex-
linked? Determine the probable genotypes for all the individuals in this pedigree.
Sandra
Daniel
George
Tom Sam Wilma Ann
Alan
Tina
Arlene
Christopher
Carla
Michael
Chapter 2 Solutions
Introduction to Genetic Analysis
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10PCh. 2 - Prob. 11P
Ch. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 16PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37PCh. 2 - Prob. 38PCh. 2 - Prob. 39PCh. 2 - Prob. 40PCh. 2 - Prob. 41PCh. 2 - Prob. 42PCh. 2 - Prob. 43PCh. 2 - Prob. 44PCh. 2 - Prob. 44.1PCh. 2 - Prob. 44.2PCh. 2 - Prob. 44.3PCh. 2 - Prob. 44.4PCh. 2 - Prob. 44.5PCh. 2 - Prob. 44.6PCh. 2 - Prob. 44.7PCh. 2 - Prob. 44.8PCh. 2 - Prob. 44.9PCh. 2 - Prob. 44.10PCh. 2 - Prob. 44.11PCh. 2 - Prob. 44.12PCh. 2 - Prob. 44.13PCh. 2 - Prob. 44.14PCh. 2 - Prob. 44.15PCh. 2 - Prob. 45PCh. 2 - Prob. 47PCh. 2 - Prob. 48PCh. 2 - Prob. 49PCh. 2 - Prob. 50PCh. 2 - Prob. 51PCh. 2 - Prob. 52PCh. 2 - Prob. 53PCh. 2 - Prob. 56PCh. 2 - Prob. 57PCh. 2 - Prob. 58PCh. 2 - Prob. 59PCh. 2 - Prob. 60PCh. 2 - Prob. 61PCh. 2 - Prob. 62PCh. 2 - Prob. 63PCh. 2 - Prob. 64PCh. 2 - Prob. 65PCh. 2 - Prob. 66PCh. 2 - Prob. 67PCh. 2 - Prob. 68PCh. 2 - Prob. 69PCh. 2 - Prob. 70PCh. 2 - Prob. 71PCh. 2 - Prob. 72PCh. 2 - Prob. 73PCh. 2 - Prob. 74PCh. 2 - Prob. 75PCh. 2 - Prob. 76PCh. 2 - Prob. 77PCh. 2 - Prob. 78PCh. 2 - Prob. 79P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Sickle cell anemia is a human genetic disorder caused by an autosomal recessive allele. A couple plan to marry and want to know the probability that they will have an affected child. With your knowledge of Mendelian inheritance, what can you tell them if (1) each has one affected parent and a parent with no family history of SCA or (2) the man is affected by the disorder but the woman has no family history of SCA?arrow_forwardGeneticists are concerned about three different genetic conditions present within their family. Achondroplasia is an autosomal dominant genetic disorder that results in short-limbed dwarfism. (A = achondroplasia allele; a = average height allele). Red-Green Color blindness is an X-linked recessive genetic disorder (Xc = color blindness allele; XC = normal color vision allele). The 7-year-old son has an autosomal recessive form of deafness. (h = deafness allele; H = normal hearing allele.) All three family members were karyotyped, and additional genetic testing was performed to determine the chromosomal location of the genes being studied. The figures below show the karyotypes of the mother and father with respect to the chromosomes containing the three genes mentioned above. Question: The couple’s 7-year-old son has all three of these genetic conditions (achondroplasia, color blindness and deafness). Taking into consideration the genotypes of his parents, what is the complete…arrow_forwardPlease consider the following pedigree. Assume that people who marry in to the family do not carry the allele unless otherwise indicated. Assume complete penetrance. I II 5 6 III 6 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Provide a genotype for individual III-6 for the most likely mode of inheritance as determined in (a).arrow_forward
- Albinism in humans is autosomal and fully recessive to normal color. A couple, who are both normal, have a daughter who is albino and a son who is normal. What is the probability that their normal son is a carrier of the albinism gene?arrow_forwardPedigree attached shows an autosomal recessive genetic disease. G is the normal allele and g is the disease-causing allele. Individual 1’s father is heterozygous (*) and his mother is homozygous dominant. Other individuals in the pedigree may be carriers, but are not marked. The question mark (?) indicates that you do not yet know anything about this individual’s phenotype with regard to the disease. part a) What is the probability that individuals 1 and 2 will have a child (5) who is a boy with the disease (the child is unborn and the sex is not yet known)? a)1/8 b)1/4 c)0 d)1/16 part b) What is the probability that the daughter (6) that individual 3 and 4 just had will have the disease? a)1/8 b)1/6 c)1/4 d)1/12arrow_forwardBelow is a pedigree chart for a family that has a history of Alkaptonuria. Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications. Given this pedigree answer the following questions. Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive? What are the genotypes for #1, #2, and #3? If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype? Why or why not?arrow_forward
- Please consider the following pedigree. Assume that people who marry in to the family do not carry the allele. Assume complete penetrance. I II III 3 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Based strictly on the characteristic patterns of inheritance that define the four different options in (a), give a definitive motivation for the most likely mode of inhertance.arrow_forwardThe following pedigree shows the inheritance of a rare genetic disorder. Determine the most likely mode of inheritance, and for exam practice (unmarked on the assignment) write a clear justification for your conclusion. Remember that some pedigrees don't provide sufficient data/information to discriminate between possibilities. If that is the case, select all the possible answers. I III Tb 2 3 1 1 3 autosomal dominant autosomal recessive Osex-linked dominant Osex-linked recessive O 2 Harrow_forwardRefer to the pedigree below which shows inheritance for achondroplasia (dwarfism), a dominantly inherited trait (denoted as D), which are the darkened circles and squares. Dwarfism (darkened shapes) are dominantly inherited, while normal height is recessively inherited (hh). Based on the pedigree, what is the correct genotype for individual #II-6? Dominant Autosomal Pedigree 2 II 2 3 II 1 2 3 6 9 10 Dd DD DD or Dd ddarrow_forward
- The pedigree below represents the inheritance of a rare genetic disorder (members joining the pedigree are not carriers). Consider the following pedigree and answer questions (i) to (vii) below. The allele descriptors are B/b. What is the mode of inheritance in this pedigree ? Y-linked inheritance X-linked recessive inheritance X-linked dominant inheritance Autosomal recessive inheritance Autosomal dominant inheritance What is the genotype of individual III-2 ? a) XbXb b) XBXB c) XBXb d) Bb e) bb What is the genotype of individual IV-3 ? a) XbXb b) XBXB c) XBXb d) Bb e) bb Individual IV-4 and an unaffected woman is planning a family. What is the probability that their first child will be phenotypically normal ? a) chance that the first child will be phenotypically normal. b) chance that the first child will be phenotypically normal. c) chance that the first female child will be phenotypically normal; all male children will be phenotypically normal. d) chance that the…arrow_forwardCystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of sticky mucus that clogs the lungs and pancreas. It is a life-threatening disease, but medical advances helped the afflicted to live through adulthood. The mother of Claudia died from cystic fibrosis, but her father was normal and never had any relative with CF. Her fiancé, Marcus, turned out to be a carrier of the CF allele. What are the genotypes of Claudia and Marcus? Claudia: ________________________ Marcus: _____________________ They planned to have four children. What is the probability that: a. all children will be normal b. at least two will be normal PLEASE SHOW COMPLETE SOLUTIONarrow_forwardCystic fibrosis (CF) is an autosomal recessive trait. A three-generation pedigree is shown below for a family that carries the mutant allele for cystic fibrosis. Note that carriers are not colored in to allow you to figure out their genotypes. Normal allele = F CF mutant allele = f What is the genotype of individual #8?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSON
Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Anatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
How stress affects your body - Sharon Horesh Bergquist; Author: TED-Ed;https://www.youtube.com/watch?v=v-t1Z5-oPtU;License: Standard Youtube License