Introduction to Genetic Analysis
11th Edition
ISBN: 9781464109485
Author: Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Publisher: W. H. Freeman
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Chapter 2, Problem 44.6P
Summary Introduction
To determine: The various assumptions that are needed for complete pedigree analysis.
Introduction: Risk analysis of a particular disease for new generations is considered based on alleles that are carried by past generations. The information about the alleles gives complete information for an individual, whether an individual is prone to a particular disease or not.
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Salim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara’s great-grandmother also had galactosemia. Sara has a sister who has three children, none of whom is affected.
What is the probability that Salim and Sara’s first child will have galactosemia? Explain your calculations.
Kate and her husband are both heterozygous for galactosemia gene. If Kate and her husband have four children, how many of their children are likely to have galactosemia?
Kelly and Sam are both unaffected carriers for two autosomal recessive
disorders, PKU (chromosome 12) and cystic fibrosis (chromosome 7). They
are expecting a daughter. What is the probability that she will be unaffected
by PKU, but effected by cystic fibrosis?
O 1/16
O 3/16
O 1/2
О 3/4
O 9/16
Chapter 2 Solutions
Introduction to Genetic Analysis
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10PCh. 2 - Prob. 11P
Ch. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 16PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37PCh. 2 - Prob. 38PCh. 2 - Prob. 39PCh. 2 - Prob. 40PCh. 2 - Prob. 41PCh. 2 - Prob. 42PCh. 2 - Prob. 43PCh. 2 - Prob. 44PCh. 2 - Prob. 44.1PCh. 2 - Prob. 44.2PCh. 2 - Prob. 44.3PCh. 2 - Prob. 44.4PCh. 2 - Prob. 44.5PCh. 2 - Prob. 44.6PCh. 2 - Prob. 44.7PCh. 2 - Prob. 44.8PCh. 2 - Prob. 44.9PCh. 2 - Prob. 44.10PCh. 2 - Prob. 44.11PCh. 2 - Prob. 44.12PCh. 2 - Prob. 44.13PCh. 2 - Prob. 44.14PCh. 2 - Prob. 44.15PCh. 2 - Prob. 45PCh. 2 - Prob. 47PCh. 2 - Prob. 48PCh. 2 - Prob. 49PCh. 2 - Prob. 50PCh. 2 - Prob. 51PCh. 2 - Prob. 52PCh. 2 - Prob. 53PCh. 2 - Prob. 56PCh. 2 - Prob. 57PCh. 2 - Prob. 58PCh. 2 - Prob. 59PCh. 2 - Prob. 60PCh. 2 - Prob. 61PCh. 2 - Prob. 62PCh. 2 - Prob. 63PCh. 2 - Prob. 64PCh. 2 - Prob. 65PCh. 2 - Prob. 66PCh. 2 - Prob. 67PCh. 2 - Prob. 68PCh. 2 - Prob. 69PCh. 2 - Prob. 70PCh. 2 - Prob. 71PCh. 2 - Prob. 72PCh. 2 - Prob. 73PCh. 2 - Prob. 74PCh. 2 - Prob. 75PCh. 2 - Prob. 76PCh. 2 - Prob. 77PCh. 2 - Prob. 78PCh. 2 - Prob. 79P
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Phenylketonuria (PKU) is a disorder caused by a recessive allele. Two carrier individuals have progeny. Answer the following questions in order and show solutions whenever relevant. 1. If they have a normal child, what is the probability that he or she will be heterozygous? 2. If they have three children, what is the probability of having 2 affected children and one normal child?arrow_forwardBob and Joan know from a blood test that they are each heterozygous (carriers) for the autosomal recessive gene that causes sickle cell disease. If their first three children are healthy, what is the probability that their fourth child will have the disease?arrow_forwardA couple seeks advice from a genetic counselor because they know that they are both carriers for cystic fibrosis (which is autosomal recessive), and the woman is a carrier for Duchenne muscular dystrophy (which is sex-linked recessive). For each of their future sons and daughters (calculate separately), what is the probability that they will be affected for: Cystic fibrosis Duchenne muscular dystrophyarrow_forward
- A young couple went to see a genetic counselor because each had a sibling affected with cystic fibrosis. (Cystic fibrosis is a recessive disease and neither member of the couple nor any of their four parents is affected). What is the probability that the female of this couple is a carrier and what are the chances that their child will be affected with cystic fibrosis?arrow_forwardDuchenne muscular dystrophy is a sex-linked recessive disorder characterized by a progressive loss of muscle tissue. Neither Carla nor Rudy has Duchenne muscular dystrophy, but their first son does have it. What can you say about Rudy's or Carla's genotype in relation with the disorder? If the couple has a second child, what is the probability that he or she will also have the disease? Show your answers with a Punnet square.arrow_forwardA couple seeks advice from a genetic counselor because they know that they are both carriers for cystic fibrosis (which is autosomal recessive), and the woman is a carrier for Duchenne muscular dystrophy (which is sex-linked recessive). For each of their future sons and daughters (calculate separately), what is the probability that they will be affected for: Both cystic fibrosis and nuscular dystrophy If the couple’s first born son has both cystic fibrosis and muscular dystrophy, what is the probability that their second born son will have both diseases?arrow_forward
- Salim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara has a sister who has three children, none of whom is affected. Sara dad has no history in his family of any sign of the diease and it is assumed to be homozygous normal. What is the probability that salim and saras first child will have galactosemia?arrow_forwardSalim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara has a sister who has three children, one of whom is affected. Sara dad has no history in his family of any sign of the diease and it is assumed to be homozygous normal. What is the probability that salim and saras first child will have galactosemia?arrow_forwardAlong with the trait in the pedigree, individual IV-6 and the woman are also both heterozygous for the autosomal dominant allele causing Huntington's disease. If they have a child, what is the probability that it will be affected by at least one of these traits? Remember to include both the trait in the pedigree and Huntington's disease in your calculations. Enter your answer to two decimal places (e.g., 0.55).arrow_forward
- Martin and Sue are contemplating having children, but Martin’s brother has an autosomal recessive disease and Sue’s great-grandmother also had the same disease. Sue has a sister who has three normal, healthy children. What is the probability that Martin and Sue’s first child will have the autosomal recessive disease? HINT draws out pedigree charts and punnett squares for Martin and Sue.arrow_forwardwhat is the probability that a couple (both heterozygous for the same recessive mutation) will have two children with the disease if the couple plans to have four children in total?arrow_forwardGalactosemia is an autosomal recessive human disease that is treatable by restricting lactose and glucose in the diet. If two individuals who are both heterozygous for the recessive galactosemia allele have three children, what is the probability that two of the children will have galactosemia and one will not? Type your answer as a fraction (not a decimal), with no spaces (e.g. 1/16).arrow_forward
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