Concept explainers
a.
To determine: The probability that the child will have cystic fibrosis.
Introduction: Cystic fibrosis is a genetic disease often affecting the lungs and also the pancreas, liver, kidneys, and intestine. The long-term effects involve difficulty in breathing and coughing up mucus as a consequence of repeated lung infections.
b.
To determine: The chance that the children will have the precise Mendelian ratio of 3:1 for normal cystic fibrosis.
Introduction: The Mendelian ratio exists of several
c.
To determine: The probability that their next three children will be normal, if their first child has cystic fibrosis.
Introduction: Cystic fibrosis is a continuous genetic disorder that induces persistent infections in the lung and restricts the strength to breathe over time. In people with CF, mutations within the transmembrane of cystic fibrosis conductance regulator gene cause the CFTR protein to become dysfunctional.
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Introduction to Genetic Analysis
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- Duchenne muscular dystrophy is sex linked and usually affects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brother has Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’s disease, what is the probability that you have received the allele?c. If your father’s brother had the disease, what is the probability that you have received the allele?arrow_forwardCystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF. a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF? b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected? c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?arrow_forwardPhenylketonuria (PKU) is a disorder caused by a recessive allele. Two carrier individuals have progeny. Answer the following questions in order and show solutions whenever relevant. a. Indicate the gene notation.b. Derive the expected genotypic and phenotypic ratios.c. If they have a normal child, what is the probability that he or she will be heterozygous?d. If they have three children, what is the probability of having 2 affected children and one normalchild?arrow_forward
- A young couple went to see a genetic counselor because each had a sibling with cystic fibrosis. (Cysticfibrosis is a recessive disease, and neither member ofthe couple nor any of their four parents is affected.)a. What is the probability that the female of thiscouple is a carrier?b. What are the chances that their child will havecystic fibrosis?c. What is the probability that their child will be acarrier of the cystic fibrosis disease allele?arrow_forwardA young couple went to see a genetic counselor because each had a sibling affected with cystic fibrosis. (Cystic fibrosis is a recessive disease and neither member of the couple nor any of their four parents is affected). What is the probability that the female of this couple is a carrier and what are the chances that their child will be affected with cystic fibrosis?arrow_forwardLuisa is a carrier of the allele for Tay-Sachs but has no sign of any eye disorder in her family. Shemarried Gerard whose mother was afflicted with retinitis pigmentosa, unlike his father. Neither of hisparents has any history of Tay-Sachs disease. 1. What are the genotypes of Luisa and Gerard? 2. If they plan to have five children, what is the probability that: a. all their children will be normal?b. they will have a daughter with retinitis pigmentosa? c. they will have a son inflicted with both conditions? d. at least 2 will be normal? (show COMPLETE solutions for this question)arrow_forward
- A woman with a rare autosomal recessive disorder was told that it was unlikely that her children would have the disorderas her husband did not have it. However, her first child has the disorder. a. What is the most likely explanation? b. Diagram the cross between the woman and her husband using a Punnett square, give the genotypic ratio (GR) and phenotypic ratio (PR) from the Punnett square. c. Based on the Punnett square results, what is the chance that her next child will have the disorder?arrow_forwardThe condition phenylketonuria is caused by a recessive allele. There are two carriers who have progeny.a. Give the gene notation. b. Give the expected genotypic and phenotypic ratios. c. What is the probability that their child will be heterozygous if they have a normal child?d. What is the probability of having two affected children and one normal child if they have three children?arrow_forwardAssume that one of Merida's sons, who is heterozygous for orange hair color, married a girl that was also heterozygous. Create a Punnett square to show the possibilities that would result if they had children. a. List the possible genotypes and phenotypes for their children. b. What are the chances of a child with orange hair? c. What are the chantes of a child with yellow?arrow_forward
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning