Introduction to Genetic Analysis
Introduction to Genetic Analysis
11th Edition
ISBN: 9781464109485
Author: Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Publisher: W. H. Freeman
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Chapter 2, Problem 64P

a.

Summary Introduction

To determine: The probability that the child will have cystic fibrosis.

Introduction: Cystic fibrosis is a genetic disease often affecting the lungs and also the pancreas, liver, kidneys, and intestine. The long-term effects involve difficulty in breathing and coughing up mucus as a consequence of repeated lung infections.

b.

Summary Introduction

To determine: The chance that the children will have the precise Mendelian ratio of 3:1 for normal cystic fibrosis.

Introduction: The Mendelian ratio exists of several phenotypes in a cross concerning Mendelian characters, especially with the ratio 3:1 prepared by the second filial generation of offspring from parents contrasting concerning a single character.

c.

Summary Introduction

To determine: The probability that their next three children will be normal, if their first child has cystic fibrosis.

Introduction: Cystic fibrosis is a continuous genetic disorder that induces persistent infections in the lung and restricts the strength to breathe over time. In people with CF, mutations within the transmembrane of cystic fibrosis conductance regulator gene cause the CFTR protein to become dysfunctional.

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A couple who are about to get married learn from studying their family histories that, in both their families, theirunaffected grandparents had siblings with cystic fibrosis(a rare autosomal recessive disease).a. If the couple marries and has a child, what is theprobability that the child will have cystic fibrosis?b. If they have four children, what is the chance that thechildren will have the precise Mendelian ratio of 3:1 fornormal:cystic fibrosis?c. If their first child has cystic fibrosis, what is theprobability that their next three children will be normal?
Sickle cell anemia is an inherited red blood cell disorder in which there are not enough healthy red blood cells to carry oxygen throughout the body. The allele that causes sickle-cell anemia is autosomal recessive (s), and the dominant allele can be represented by S. How many offspring will be affected by the disorder if the mother is a carrier, and the father appears to be normal? (Include the gender) a. b. How many will become carriers? (include the gender) A- 三三三 四 四 II !!
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Introduction to Genetic Analysis

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