Introduction to Genetic Analysis
11th Edition
ISBN: 9781464109485
Author: Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Publisher: W. H. Freeman
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Chapter 2, Problem 44.1P
Summary Introduction
To determine: The representation of the hereditary pattern of galactosemia in a pedigree chart.
Introduction. Pedigree analysis is the study of the hereditary patterns of the various generations of the family. The pedigree analysis helps to track the origin and the way a disease is being inherited in a family. Various symbols are used to depict various members along with the affected and unaffected individuals in the family.
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Kate and her husband are both heterozygous for galactosemia gene. If Kate and her husband have four children, how many of their children are likely to have galactosemia?
Ann's family has a history of cystic fibrosis, a recessive genetic disease. In the pedigree, family members who are afflicted with the disease are shown in red. Members who are unafflicted may or may not be carriers. Which of the given family members can be identified definitively as unafflicted carriers of cystic fibrosis?
Salim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara’s great-grandmother also had galactosemia. Sara has a sister who has three children, none of whom is affected.
What is the probability that Salim and Sara’s first child will have galactosemia? Explain your calculations.
Chapter 2 Solutions
Introduction to Genetic Analysis
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10PCh. 2 - Prob. 11P
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- Cystic fibrosis is an autosomal recessive disorder that runs in Ann's family. Consider the figure of a pedigree of the known occurrences of cystic fibrosis in her family. Ann Filled (red) circles represent affected females. Filled (red) squares represent affected males. Unfilled (tan) circles, such as Ann's circle, represent symptomless females. Unfilled (tan) squares represent symptomless males.arrow_forwardSalim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara’s great-grandmother also had galactosemia. Sara has a sister who has three children, none of whom is affected.a. Construct a genetic pedigree for this family showing the possible genotype of each member.b. What is the probability that Salim and Sara’s first child will have galactosemia? Explain your calculations.arrow_forwardA couple seeks advice from a genetic counselor because they know that they are both carriers for cystic fibrosis (which is autosomal recessive), and the woman is a carrier for Duchenne muscular dystrophy (which is sex-linked recessive). For each of their future sons and daughters (calculate separately), what is the probability that they will be affected for: Both cystic fibrosis and nuscular dystrophy If the couple’s first born son has both cystic fibrosis and muscular dystrophy, what is the probability that their second born son will have both diseases?arrow_forward
- A couple seeks advice from a genetic counselor because they know that they are both carriers for cystic fibrosis (which is autosomal recessive), and the woman is a carrier for Duchenne muscular dystrophy (which is sex-linked recessive). For each of their future sons and daughters (calculate separately), what is the probability that they will be affected for: Cystic fibrosis Duchenne muscular dystrophyarrow_forwardFor this pedigree, give the most likely mode of inheritance, assuming that the trait is rare. For the pedigree, what is the probability that III-4 and III-5 will have a boy AND he will be affected?arrow_forwardKelly and Sam are both unaffected carriers for two autosomal recessive disorders, PKU (chromosome 12) and cystic fibrosis (chromosome 7). They are expecting a daughter. What is the probability that she will be unaffected by PKU, but effected by cystic fibrosis? O 1/16 O 3/16 O 1/2 О 3/4 O 9/16arrow_forward
- The following pedigree describes the inheritance of Lesch-Nyhan syndrome, an x-linked recessive disease. Affected individuals are shaded. what is the probability, that the indicated child (IV.1) will be affected by Lesch-Nyhan syndrome? show solutionarrow_forwardGalactosemia is an autosomal recessive human disease that is treatable by restricting lactose and glucose in the diet. If two individuals who are both heterozygous for the recessive galactosemia allele have three children, what is the probability that two of the children will have galactosemia and one will not? Type your answer as a fraction (not a decimal), with no spaces (e.g. 1/16).arrow_forwardThe pedigree below shows a family with a history of an autosomal recessive genetic disease with one individual's genotype indicated (G denotes the normal allele and g denotes the disease-causing allele). * O 0 O 1/8 1/4 O 1/16 Individual 1's father is known to be heterozygous (*) and his mother is known to be homozygous dominant. Other individuals in the pedigree may be carriers, but are not marked. The question mark (?) indicates that you do not yet know anything about this individual's phenotype with regard to the disease. Part 1 What is the probability that individuals 1 and 2 will have a child (5) who is a male with the disease (the child is unborn and the sex is not yet known)? O 1/4 1 O 1/6 5 1/8 2 01/12 gg 3 Part 2 What is the probability that the daughter (female)(6) that individual 3 and 4 just had will have the disease? 6arrow_forward
- Using the pedigree, assume that the disease is caused by an autosomal dominant allele, R. Give the genotype of the following individuals: (a) III-4 (the girl at lower right) (b) II-3 (the girl’s mother) (c) II-4 (the girl’s father)arrow_forwardThe second pedigree involves albinism, an autosomal recessive trait. A couple has a son with normal pigmentation, a daughter with normal pigmentation, and an albino son. Another couple has three children, a son with normal pigmentation and two daughters with normal pigmentation. The daughter from the first couple marries the man from the second couple and they have three children together: an albino son, an albino daughter, and a daughter with normal pigmentation.Draw the pedigree on the next pagearrow_forwardIs this pedigree dominant or recessive. Which best defines this pedigree Autosomal or sex-linked?arrow_forward
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