Introduction to Genetic Analysis
11th Edition
ISBN: 9781464109485
Author: Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Publisher: W. H. Freeman
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Chapter 2, Problem 44.15P
Summary Introduction
To determine: The human dilemma possessed by the family in case of such disease.
Introduction: Certain diseases are not genetic and cannot be passed on to the next generation. But various diseases can be inherited from the parents to their generation.
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Kate and her husband are both heterozygous for galactosemia gene. If Kate and her husband have four children, how many of their children are likely to have galactosemia?
Salim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara has a sister who has three children, none of whom is affected. Sara dad has no history in his family of any sign of the diease and it is assumed to be homozygous normal. What is the probability that salim and saras first child will have galactosemia?
Salim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara has a sister who has three children, one of whom is affected. Sara dad has no history in his family of any sign of the diease and it is assumed to be homozygous normal. What is the probability that salim and saras first child will have galactosemia?
Chapter 2 Solutions
Introduction to Genetic Analysis
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10PCh. 2 - Prob. 11P
Ch. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 16PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37PCh. 2 - Prob. 38PCh. 2 - Prob. 39PCh. 2 - Prob. 40PCh. 2 - Prob. 41PCh. 2 - Prob. 42PCh. 2 - Prob. 43PCh. 2 - Prob. 44PCh. 2 - Prob. 44.1PCh. 2 - Prob. 44.2PCh. 2 - Prob. 44.3PCh. 2 - Prob. 44.4PCh. 2 - Prob. 44.5PCh. 2 - Prob. 44.6PCh. 2 - Prob. 44.7PCh. 2 - Prob. 44.8PCh. 2 - Prob. 44.9PCh. 2 - Prob. 44.10PCh. 2 - Prob. 44.11PCh. 2 - Prob. 44.12PCh. 2 - Prob. 44.13PCh. 2 - Prob. 44.14PCh. 2 - Prob. 44.15PCh. 2 - Prob. 45PCh. 2 - Prob. 47PCh. 2 - Prob. 48PCh. 2 - Prob. 49PCh. 2 - Prob. 50PCh. 2 - Prob. 51PCh. 2 - Prob. 52PCh. 2 - Prob. 53PCh. 2 - Prob. 56PCh. 2 - Prob. 57PCh. 2 - Prob. 58PCh. 2 - Prob. 59PCh. 2 - Prob. 60PCh. 2 - Prob. 61PCh. 2 - Prob. 62PCh. 2 - Prob. 63PCh. 2 - Prob. 64PCh. 2 - Prob. 65PCh. 2 - Prob. 66PCh. 2 - Prob. 67PCh. 2 - Prob. 68PCh. 2 - Prob. 69PCh. 2 - Prob. 70PCh. 2 - Prob. 71PCh. 2 - Prob. 72PCh. 2 - Prob. 73PCh. 2 - Prob. 74PCh. 2 - Prob. 75PCh. 2 - Prob. 76PCh. 2 - Prob. 77PCh. 2 - Prob. 78PCh. 2 - Prob. 79P
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- 152 Phenylketonuria (PKU) is a disorder caused by a recessive allele. Two carrier individuals have progeny. Answer the following questions in order and show solutions whenever relevant. If they have a normal child, what is the probability that he or she will be heterozygous? If they have three children, what is the probability of having 2 affected children and one normal child?arrow_forwardKelly and Sam are both unaffected carriers for two autosomal recessive disorders, PKU (chromosome 12) and cystic fibrosis (chromosome 7). They are expecting a daughter. What is the probability that she will be unaffected by PKU, but effected by cystic fibrosis? O 1/16 O 3/16 O 1/2 О 3/4 O 9/16arrow_forwardThe autosomal (not X-linked) gene for brachydactyly, short fingers, is dominant to normal finger length. Assume that a female with brachydactyly in the heterozygous condition is married to a man with normal fingers. What is the probability that(a) their first child will have brachydactyly?(b) their first two children will have brachydactyly?(c) their first child will be a brachydactylous girl?arrow_forward
- Annabeth and Percy are concerned about having a child with Niemann - Pick disease, which causes abnormal accumulation of fat in cells. This condition, which is very rare, has affected Annabeth's niece (her brother's daughter) and Percy's aunt (his father's sister ). No one else in either family has the condition. What is the probability Annabeth and Percy's first child will have the disease? What is the probability Annabeth and Percy's first child will have the disease? 1/64 1/32 1/24 1/18 1/12 1/9 1/4 None of these abovearrow_forwardA WOMAN IS HETEROZYGOUS FOR TWO HARMFUL RECESSIVE ALLELES IN DIFFERENT CHROMOSOMES, ONE FOR PHENYLKETONURIA (PKU) AND THE OTHER FOR CYSTIC FIBROSIS (CF). SHE MARRIES AN UNAFFECTED MAN WHO IS A CARRIER FOR NEITHER DISEASE. IF SHE HAS A DAUGHTER, WHAT IS THE PROBABILITY THAT THE CHILD WILL CARRY NEITHER OF THE RECESSIVE ALLELES? EXACTLY ONE? BOTH?arrow_forwardPhenylketonuria (PKU) is a disorder caused by a recessive allele. Two carrier individuals have progeny. If they have a normal child, what is the probability that he or she will be heterozygous? Show solutions.arrow_forward
- Salim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara’s great-grandmother also had galactosemia. Sara has a sister who has three children, none of whom is affected.a. Construct a genetic pedigree for this family showing the possible genotype of each member.b. What is the probability that Salim and Sara’s first child will have galactosemia? Explain your calculations.arrow_forwardGalactosemia is an autosomal recessive human disease that is treatable by restricting lactose and glucose in the diet. If two individuals who are both heterozygous for the recessive galactosemia allele have three children, what is the probability that two of the children will have galactosemia and one will not? Type your answer as a fraction (not a decimal), with no spaces (e.g. 1/16).arrow_forwardBob and Joan know from a blood test that they are each heterozygous (carriers) for the autosomal recessive gene that causes sickle cell disease. If their first three children are healthy, what is the probability that their fourth child will have the disease?arrow_forward
- Cystic fibrosis in humans is caused by mutations in a single gene and is inherited as an autosomal (non-sex chromosome) recessive trait. An unaffected couple has two children. The first child has cystic fibrosis, and the second child is unaffected. What is the probability that the second child is a carrier (heterozygous) for the mutation that causes the disease? 2/3 1 1/2 3/4arrow_forwardAlbinism is caused by an autosomal recessive allele that interferes with skin pigmentation in mammals. Two normally pigmented human parents already have an albino boy. They plan to continue to have children until they get a girl. Some or all of this information is important for each of the questions below. a) What is the probability that their next child (currently unborn) will be a girl with albinism? Explain your reasoning. b) What is the probability their first female child will be albino? Explain your reasoning. c) The answer to part (b) is different (and, yes, the answer is different) from the answer to part (a). Explain why. (Hint: it has something to do with the underlined words.)arrow_forwardwhat is the probability that a couple (both heterozygous for the same recessive mutation) will have two children with the disease if the couple plans to have four children in total?arrow_forward
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