Introduction to Genetic Analysis
11th Edition
ISBN: 9781464109485
Author: Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Publisher: W. H. Freeman
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Chapter 2, Problem 53P
a.
Summary Introduction
To determine: The condition of inheritance in the given diagram.
Introduction: Genetic abnormalities are those that occupy the chromosomal location and produce the non-functional proteins. The abnormalities can be caused due either to mutation in a single
b.
Summary Introduction
To determine: The probability of the first child to be diseased when person 1 and person 2 in the given pedigree get married.
Introduction: The gene transferred from parents may be dominant as well as the recessive. The expression of the genes or alleles determines the type of abnormalities in the progenies, which may be of four types, autosomal dominant and autosomal recessive, X-linked dominant and X-linked recessive.
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Assume that one of Merida's sons, who is heterozygous for orange hair color, married a girl that was
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PEDIGREE: Shaded individuals in the pedigree have a genetic disease. Individuals marrying into the family, that is individuals II–1, II–4 and II–6, have no history of the disease in their families.1. Determine the mode of inheritance ______________________________2. Give the genotypes of the following individuals
The pedigree shown below was obtained for a rare kidney disease. Determine the mode of inheritance for this condition and state your reasoning for your answer.
Chapter 2 Solutions
Introduction to Genetic Analysis
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10PCh. 2 - Prob. 11P
Ch. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 16PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37PCh. 2 - Prob. 38PCh. 2 - Prob. 39PCh. 2 - Prob. 40PCh. 2 - Prob. 41PCh. 2 - Prob. 42PCh. 2 - Prob. 43PCh. 2 - Prob. 44PCh. 2 - Prob. 44.1PCh. 2 - Prob. 44.2PCh. 2 - Prob. 44.3PCh. 2 - Prob. 44.4PCh. 2 - Prob. 44.5PCh. 2 - Prob. 44.6PCh. 2 - Prob. 44.7PCh. 2 - Prob. 44.8PCh. 2 - Prob. 44.9PCh. 2 - Prob. 44.10PCh. 2 - Prob. 44.11PCh. 2 - Prob. 44.12PCh. 2 - Prob. 44.13PCh. 2 - Prob. 44.14PCh. 2 - Prob. 44.15PCh. 2 - Prob. 45PCh. 2 - Prob. 47PCh. 2 - Prob. 48PCh. 2 - Prob. 49PCh. 2 - Prob. 50PCh. 2 - Prob. 51PCh. 2 - Prob. 52PCh. 2 - Prob. 53PCh. 2 - Prob. 56PCh. 2 - Prob. 57PCh. 2 - Prob. 58PCh. 2 - Prob. 59PCh. 2 - Prob. 60PCh. 2 - Prob. 61PCh. 2 - Prob. 62PCh. 2 - Prob. 63PCh. 2 - Prob. 64PCh. 2 - Prob. 65PCh. 2 - Prob. 66PCh. 2 - Prob. 67PCh. 2 - Prob. 68PCh. 2 - Prob. 69PCh. 2 - Prob. 70PCh. 2 - Prob. 71PCh. 2 - Prob. 72PCh. 2 - Prob. 73PCh. 2 - Prob. 74PCh. 2 - Prob. 75PCh. 2 - Prob. 76PCh. 2 - Prob. 77PCh. 2 - Prob. 78PCh. 2 - Prob. 79P
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- Examine the pedigree and answer the following questions; shaded individuals show the trait; genotypes are all unknown. The individual marked with the question mark is of an unknown genotype but does have the trait. A. What mode of inheritance is the most likely for this trait, autosomal recessive or autosomal dominant? State your rationale for full credit. B. What is the genotype of the individual marked with the question mark? (Heterozygous, homozygous, or unknown)arrow_forwardPhenylketonuria (PKU) is a disorder caused by a recessive allele. Two carrier individuals have progeny. Answer the following questions in order and show solutions whenever relevant. a. Indicate the gene notation.b. Derive the expected genotypic and phenotypic ratios.c. If they have a normal child, what is the probability that he or she will be heterozygous?d. If they have three children, what is the probability of having 2 affected children and one normalchild?arrow_forwardExamine the pedigree and answer the following questions; shaded individuals show the trait; genotypes are all unknown. The individual marked with the question mark is of an unknown genotype but lacks the trait. A. What mode of inheritance is the most likely, autosomal recessive or autosomal dominant? State your rationale for full credit. B. What is the genotype of the individual designated with the question mark? (Heterozygous, homozygous, or unknown). C. What are the genotypes of the parents in generation I? (Heterozygous, homozygous, or unknown). D. What are the genotypes of the three children of generation IV? (Heterozygous, homozygous, or unknown).arrow_forward
- The pedigree below concerns a certain rare disease that is incapacitating but not fatal.a. Determine the most likely mode of inheritance of this disease. b. Write the genotype of each family member according to your proposed mode of inheritance. c. If you were this family’s doctor, how would you advise the three couples in the third generation about the likelihood of having an affected child?arrow_forwardThe following pedigree illustrates the inheritance of Duchenne Muscular Dystrophy, a condition characterized by progressive weakness and degeneration of skeletal muscles due to absence of dystrophin. 2.arrow_forwarda. The pedigree follows the inheritance of a relatively common trait. Is the trait most likely autosomal dominant, autosomal recessive, X-linked dominant, or X-linked recessive? Explain your reasoning. b. If the couple marked with a “*” had another child, what is the probability that it would be an affected daughter? (Note: this is a compound outcome.)arrow_forward
- 15. The following pedigree shows inheritance of Huntington's disease, a fatal genetic disorder that causes neurodegeneration. Since signs and symptoms usually do not appear until adulthood, many who are carriers may not realize their risk of passing on the disease-causing allele. The following pedigree represents a family in which some people are affected by Huntington's disease. Reeessive Trit er btmnt be Mec yplicalty Hinheteearrow_forwardSickle cell anemia is an inherited red blood cell disorder in which there are not enough healthy red blood cells to carry oxygen throughout the body. The allele that causes sickle-cell anemia is autosomal recessive (s), and the dominant allele can be represented by S. How many offspring will be affected by the disorder if the mother is a carrier, and the father appears to be normal? (Include the gender) a. b. How many will become carriers? (include the gender) A- 三三三 四 四 II !!arrow_forwardThe condition phenylketonuria is caused by a recessive allele. There are two carriers who have progeny.a. Give the gene notation. b. Give the expected genotypic and phenotypic ratios. c. What is the probability that their child will be heterozygous if they have a normal child?d. What is the probability of having two affected children and one normal child if they have three children?arrow_forward
- A young couple went to see a genetic counselor because each had a sibling affected with cystic fibrosis. (Cystic fibrosis is a recessive disease, and neither member of the couple nor any of their four parents is affected.) a. What is the probability that the female of this couple is a carrier? b. What are the chances that their child will be affected with cystic fibrosis? c. What is the probability that their child will be a carrier of the cystic fibrosis mutation?arrow_forwardA couple who are about to get married learn from studying their family histories that, in both their families, theirunaffected grandparents had siblings with cystic fibrosis(a rare autosomal recessive disease).a. If the couple marries and has a child, what is theprobability that the child will have cystic fibrosis?b. If they have four children, what is the chance that thechildren will have the precise Mendelian ratio of 3:1 fornormal:cystic fibrosis?c. If their first child has cystic fibrosis, what is theprobability that their next three children will be normal?arrow_forwardAssume no Bombay allele for this entire question.) Consider a cross between someone with blood type B+ with someone with blood type A+ (and you don’t know their genotype). a. Can they have a child with blood type O-? If not, why not? If so, give the genotypes of the parents that would allow this. (Remember to include the genotypes for the A/B/O gene as well as the Rh gene. ) Give two different sets of genotypes for these parents (B+ and A+) that would NOT allow them to have an O- child. Let’s say these two parents have a child with blood type B-. Give the genotypes of the parents and the child.arrow_forward
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