Introduction to Genetic Analysis
11th Edition
ISBN: 9781464109485
Author: Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Publisher: W. H. Freeman
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Chapter 2, Problem 44.12P
Summary Introduction
To determine: The difference in the pedigree of Person J’s and Person M’s families.
Introduction: The pedigree of each family is different, as it depends on the alleles that are carried by each generation of a family. The occurrence of a particular disorder in certain generations depends on the inheritance pattern of the family.
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Kate and her husband are both heterozygous for galactosemia gene. If Kate and her husband have four children, how many of their children are likely to have galactosemia?
Martin and Sue are contemplating having children, but Martin’s brother has an autosomal recessive disease and Sue’s great-grandmother also had the same disease. Sue has a sister who has three normal, healthy children. What is the probability that Martin and Sue’s first child will have the autosomal recessive disease? HINT draws out pedigree charts and punnett squares for Martin and Sue.
Ann's family has a history of cystic fibrosis, a recessive genetic disease. In the pedigree, family members who are afflicted with the disease are shown in red. Members who are unafflicted may or may not be carriers. Which of the given family members can be identified definitively as unafflicted carriers of cystic fibrosis?
Chapter 2 Solutions
Introduction to Genetic Analysis
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10PCh. 2 - Prob. 11P
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- Does the phenotype indicated by the red circles and squares in this pedigree show an inheritance pattern that is autosomal dominant, autosomal recessive, or X-linked?arrow_forwardThe second pedigree involves albinism, an autosomal recessive trait. A couple has a son with normal pigmentation, a daughter with normal pigmentation, and an albino son. Another couple has three children, a son with normal pigmentation and two daughters with normal pigmentation. The daughter from the first couple marries the man from the second couple and they have three children together: an albino son, an albino daughter, and a daughter with normal pigmentation.Draw the pedigree on the next pagearrow_forwardA couple seeks advice from a genetic counselor because they know that they are both carriers for cystic fibrosis (which is autosomal recessive), and the woman is a carrier for Duchenne muscular dystrophy (which is sex-linked recessive). For each of their future sons and daughters (calculate separately), what is the probability that they will be affected for: Cystic fibrosis Duchenne muscular dystrophyarrow_forward
- Salim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara’s great-grandmother also had galactosemia. Sara has a sister who has three children, none of whom is affected. What is the probability that Salim and Sara’s first child will have galactosemia? Explain your calculations.arrow_forwardA young couple went to see a genetic counselor because each had a sibling affected with cystic fibrosis. (Cystic fibrosis is a recessive disease and neither member of the couple nor any of their four parents is affected). What is the probability that the female of this couple is a carrier and what are the chances that their child will be affected with cystic fibrosis?arrow_forwardCystic fibrosis is an autosomal recessive disorder that runs in Ann's family. Consider the figure of a pedigree of the known occurrences of cystic fibrosis in her family. Ann Filled (red) circles represent affected females. Filled (red) squares represent affected males. Unfilled (tan) circles, such as Ann's circle, represent symptomless females. Unfilled (tan) squares represent symptomless males.arrow_forward
- A man and a woman have two children. One of the two children is a boy with sickle-cell disease. The other child is a girl without sickle-cell disease. Neither of the parents are affected. How would this family be represented in a pedigree? Multiple Choice A. Father = half shaded square, Mother = half shaded circle, Son = fully shaded square, Daughter = circle with a question mark B. Father = square with no shading, Mother = half shaded circle, Son = fully shaded square, Daugther = circle with a question mark C. Father = half shaded square, Mother = half shaded circle, Son = fully shaded square, Daughter = half shaded circle D. Father = square with no shading, Mother = half shaded circle, Son = half shaded square, Daughter = circle with no shadingarrow_forwardHemophilia is caused by an X-linked recessive mutation in humans. If a man whose paternal uncle (father's brother) was a hemophiliac marries a woman whose brother is also a hemophiliac, what is the probability that their first child will have hemophilia? (Assume that no other cases of hemophilia exist in the pedigree.) 1/3 0 1/8 0 1/4 1/2arrow_forwardBob and Joan know from a blood test that they are each heterozygous (carriers) for the autosomal recessive gene that causes sickle cell disease. If their first three children are healthy, what is the probability that their fourth child will have the disease?arrow_forward
- Kelly and Sam are both unaffected carriers for two autosomal recessive disorders, PKU (chromosome 12) and cystic fibrosis (chromosome 7). They are expecting a daughter. What is the probability that she will be unaffected by PKU, but effected by cystic fibrosis? O 1/16 O 3/16 O 1/2 О 3/4 O 9/16arrow_forwardFor this pedigree, give the most likely mode of inheritance, assuming that the trait is rare. For the pedigree, what is the probability that III-4 and III-5 will have a boy AND he will be affected?arrow_forwardIs this pedigree dominant or recessive. Which best defines this pedigree Autosomal or sex-linked?arrow_forward
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