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Pompe disease is a glycogen storage disorder caused by a lack of ⍺-glucosidase, the enzyme that converts glycogen to glucose in the muscles. Babies born with this disorder die by the age of two. pope disease is a genetic disorder caused by the presence of two recessive autosomal alleles. A. A man and a woman heterozygous for the condition have two female unaffected children. Determine, using a Punnett square, the probability, expressed as a whole number percentage, of a fourth baby being born a male with Pompe disease. B. Iftheman,fromthepreviousquestion,hadtypeAbloodandthewomanhadtypeO blood, what would be probability of them having a daughter with type O blood and affected with Pompe disease? (Show clearly your calculations and express your answer as a frequency between 0 - 1 and rounded to 2 decimal places)

Assume that a particular unusual phenotype is caused by an autosomal recessive allele. John marries Jane, and they have a daughter Mia together who has the unusual phenotype. John has a brother Carlos who appears normal. Jane has a sister Margit with the unusual phenotype. John and Jane are not related, and none of their parents have the unusual phenotype. Draw a 3-generation pedigree that depicts the entire scenario and assign the most likely genotypes to each individual. (You can use any letter you wish to represent the gene.) Yes, you should include Jane's parents and sister, and also John's parents and brother, as part of the pedigree. And don't forget Mia!

Can you please help answer this question and explain how to solve it.

Marfan’s syndrome is a disorder of the fibrous connective tissue, characterized by many symptoms, includinglong, thin digits; eye defects; heart disease; and long limbs. (Flo Hyman, the American volleyball star, suf-fered from Marfan’s syndrome. She died from a ruptured aorta.) a. Use the pedigree above to propose a mode of in-heritance for Marfan’s syndrome. b. What genetic phenomenon is shown by this pedigree?c. Speculate on a reason for such a phenomenon.

Examine the pedigree and answer the following questions; shaded individuals show the trait; genotypes are all unknown. The individual marked with the question mark is of an unknown genotype but lacks the trait. A. What mode of inheritance is the most likely, autosomal recessive or autosomal dominant? State your rationale for full credit. B. What is the genotype of the individual designated with the question mark? (Heterozygous, homozygous, or unknown). C. What are the genotypes of the parents in generation I? (Heterozygous, homozygous, or unknown). D. What are the genotypes of the three children of generation IV? (Heterozygous, homozygous, or unknown).

Frank and Susan both have freckles but they're firstborn son Lawrence does not demonstrate the characteristics. What are the most likely genotype of Frank Susan and Lawrence?