Human Physiology
15th Edition
ISBN: 9781259864629
Author: Fox, Stuart Ira
Publisher: Mcgraw-hill Education,
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Chapter 7, Problem 35RA
Summary Introduction
To review:
The value of membrane potential at 0.5 msec (milliseconds) after the beginning of the action potential.
Introduction:
Membrane potential can be defined as the difference in electric potential between the interior and the exterior of a cell. It ranges from -40 mV (millivolts) to -80 mV. The action potential is produced by the rapid influx of sodium ions which is then followed by a slightly slower movement of potassium ions to the outside of the cell.
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1. What ions are flowing (and in which direction) both during the rising phase
and the falling phase of the action potential?
2. What are the values of both the 'y' (vertical) axis and the 'x' (horizontal) axis.
3. If extracellular levels of K+ rose (a condition called hyperkalemia), how would
that affect the resting membrane potential?
3
Refer to the figure below to explain the mediation of action potentials by neurons using sodium and potassium channels at each of the six timepoints indicated.
In the figure to the left, name the 4 phases of the action potential (Note: you have to write in where phase 4 occurs). Describe what happens in each phase with a focus on Na+ and K+ flow through channels and the membrane potential.
Discuss the importance of threshold. How does this relate to the concept of APs being all or none?
Chapter 7 Solutions
Human Physiology
Ch. 7 - Draw a neuron, label its parts, and describe the...Ch. 7 - Distinguish between sensory neurons, motor...Ch. 7 - Describe the structure of the neurilemma, and...Ch. 7 - Explain how myelin sheaths are formed in the CNS....Ch. 7 - Explain what is meant by the blood-brain barrier....Ch. 7 - Define the terms depolarization and...Ch. 7 - Prob. 4bCPCh. 7 - Describe how gating of Na+andK+ in the axon...Ch. 7 - Prob. 5aCPCh. 7 - Prob. 5bCP
Ch. 7 - Prob. 6aCPCh. 7 - Describe the location of neurotransmitters within...Ch. 7 - Describe the sequence of events by which action...Ch. 7 - Explain how chemically regulated channels differ...Ch. 7 - Prob. 8CPCh. 7 - Prob. 9aCPCh. 7 - Prob. 9bCPCh. 7 - Prob. 10CPCh. 7 - Prob. 11CPCh. 7 - Prob. 12aCPCh. 7 - Prob. 12bCPCh. 7 - Prob. 13aCPCh. 7 - Prob. 13bCPCh. 7 - Prob. 14aCPCh. 7 - Describe the mechanism of action of glycine and...Ch. 7 - Give examples of endogenous opioid polypeptides,...Ch. 7 - Prob. 15bCPCh. 7 - Prob. 16CPCh. 7 - Prob. 17aCPCh. 7 - Prob. 17bCPCh. 7 - Prob. 17cCPCh. 7 - Prob. 1RACh. 7 - Prob. 2RACh. 7 - Prob. 3RACh. 7 - Prob. 4RACh. 7 - Repolarization of an axon during an action...Ch. 7 - As the strength of a depolarizing stimulus to an...Ch. 7 - Prob. 7RACh. 7 - Which of these is not a characteristic of synaptic...Ch. 7 - Prob. 9RACh. 7 - Prob. 10RACh. 7 - Prob. 11RACh. 7 - Prob. 12RACh. 7 - Prob. 13RACh. 7 - Prob. 14RACh. 7 - Prob. 15RACh. 7 - Prob. 16RACh. 7 - Prob. 17RACh. 7 - Which of these may be produced by the action of...Ch. 7 - Prob. 19RACh. 7 - In a step-by-step manner, explain how the...Ch. 7 - Prob. 21RACh. 7 - Prob. 22RACh. 7 - Prob. 23RACh. 7 - Prob. 24RACh. 7 - Once an EPSP is produced in a dendrite, how does...Ch. 7 - Prob. 26RACh. 7 - List the endogenous opioids in the brain and...Ch. 7 - Explain what is meant by long-term potentiation...Ch. 7 - Prob. 29RACh. 7 - Prob. 30RACh. 7 - Prob. 31RACh. 7 - Prob. 32RACh. 7 - Prob. 33RACh. 7 - Explain the nature of the endocannabinoids....Ch. 7 - Prob. 35RACh. 7 - Prob. 36RACh. 7 - Prob. 37RACh. 7 - Prob. 38RACh. 7 - Prob. 39RACh. 7 - Use the figure below (from figure 7.34) to answer...
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- Sodium, chloride, and potassium ions are involved in setting up voltages across neuronal membranes. a. Describe a situation in which chloride ions can result in the same change in membrane potential as the sodium ions in the question above.arrow_forwardConstruct a personalized flow chart and show the summary of the events involved for the propagation of action potential along the neuron. Highlight the role being played by ions.arrow_forwardDraw details of the repolarization phase of an action potential from the following descriptions of the sequences of AfterHyperPolarization (AHP) and AfterDePolarization (ADP) sequences. Make the distinct phases clear and noticeable (5 % each) A complex AHP consisting of a first component AHP, an ADP, and a second component AHP before repolarization to resting membrane potential a first fast AHP component, followed by a slower AHP, followed by a fast ADP, and a second late AHP component before repolarization to restarrow_forward
- Consider the following three diagrams of a nerve cell membrane. They show resting potential, depolarization, and hyperpolarization. Figure out which one is which, then draw them in the order they occur in a cell that undergoes an action potential outside + Na* inside K* Na* Nat K Nat K Na potential: -80 mV outside + Na K* Na* inside Na+ K Nat Na* K+ potential: +30 mV outside Na Na Na Na* K+ inside K* Na* Kt potential: -70 mVarrow_forwardThe presence of an electrical gradient is responsible for both the resting membrane potential and the action potential in the neuron.a. In this case who is responsible for maintaining the electric gradient to produce a potential for the resting membrane?b. Explain what is meant by an electrical gradient in the context of a cell (neuron)!arrow_forward, illustrate below the phases of an action potential. Include in your figure the following:arrow_forward
- In an experiment, the extracellular [Na+] surrounding a nerve cell was reduced from 145 to 45 mM. Which of the following is the most likely effect of this on action potentials? No action potentials would occur because the concentration of extracellular Na+ is too low. The membrane potential would become more negative so the threshold for action potential generation could not be reached. The nerve cell would still produce an action potential but its amplitude would be reduced and the depolarisation phase would be slower. The nerve cell would still produce an action potential but its amplitude would be reduced and the depolarization phase would be more rapid.arrow_forwardDescribe the contribution of each of the following to the establishment and maintenance of membrane potential: Part A Na+K+ Pump Passive movement of K+ across the membrane Passive movement of Na+ across the membrane Part B Resting membrane potential is approximately -70mV. Explain what resting membrane potential is and what -70mV refers to.arrow_forwardDescribe the “all-or-none” principle of action potentials. Does the restoration of a resting membrane potential depend on active or passive processes. Explain.arrow_forward
- Explain the following; If a drug partly blocks a membrane’s potassium channels, how does it affect the action potential? Suppose the threshold of a neuron were the same as the neuron’s resting potential. What would happen? At what frequency would the cell produce action potentials?arrow_forwardCompare the resting membrane potential of a neuron with the potassium and sodium equilibrium potentials. Explain how this comparison relates to the relative permeabilities of the resting plasma membrane to these two ions.arrow_forwardConsider the following image that shows the membrane potential in a neuron when it is transmitting an electrical signal: 2 1 What does arrow "1" represent? The hyperpolarization potential The threshold potential The resting membrane potential The action potentialarrow_forward
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