Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 12, Problem 10P
Which of the following would be suggested by a DNase hypersensitive site?
| a. | No transcription occurs in this region of the chromosome. |
| b. | The chromatin is in a more open state than a region without the hypersensitive site. |
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A cell is homozygous for a LOF mutation in the histone acetyltransferase (HAT) gene. Which of the following is/are true?
a. Chromatin in the cell will be more condensed than usual, decreasing expression of genes that should be expressed.
b. This will lead to histones with more positive charges on their tails, increasing the interaction between histones and the DNA backbone.
c. This will lead to a decrease in DNA methylation and therefore cause an increase in gene expression.
d. Chromatin in the cell will be less condensed than usual, increasing expression of genes that should not be expressed.
Loosening the chromatin structure occurs because of
Select one:
a. Lysine methylation
b. Lysine acetylation
c. Lysine phosphorylation
d. Lysine sumoylation
Which of the following statements correctly describes the structure of chromatin around the promoter of an active eukaryotic gene?
O A. It is in the form of heterochromatin and the nucleosomes are tightly wrapped.
O B. It is in the form of euchromatin and the nucleosomes are cleared from the region allowing for an open and accessible configuration
OC.A repressor protein is bound to the chromatin blocking RNA polymerase.
O D.Both B and C.
Chapter 12 Solutions
Genetics: From Genes to Genomes
Ch. 12 - For each of the terms in the left column, choose...Ch. 12 - Many proteins other than histones are found...Ch. 12 - What difference exists between the compaction of...Ch. 12 - What is the role of the core histones in...Ch. 12 - a. About how many molecules of histone H2A would...Ch. 12 - The enzyme micrococcal nuclease can cleave...Ch. 12 - a. What letters are used to represent the short...Ch. 12 - About 2000 G bands are visible in a...Ch. 12 - Suppose you performed a fluorescence in situ...Ch. 12 - Which of the following would be suggested by a...
Ch. 12 - For each of the following pairs of chromatin...Ch. 12 - a. Drosophila b. Humans Give examples of...Ch. 12 - One histone modification that is seen consistently...Ch. 12 - Recently, scientists constructed a transgene that...Ch. 12 - Drosophila geneticists have isolated many...Ch. 12 - On the following figures, genes A and B are on the...Ch. 12 - Prob. 17PCh. 12 - The first page of this chapter displays photos of...Ch. 12 - The human genome contains about 3 billion base...Ch. 12 - The mitotic cell divisions in the early embryo of...Ch. 12 - In an experiment published in the journal Cell in...Ch. 12 - a. What DNA sequences are found at the telomeres...Ch. 12 - Prob. 23PCh. 12 - a. In a fluorescent in situ hybridization FISH...Ch. 12 - If you are comparing the two telomeres in each...Ch. 12 - a. What DNA sequences are commonly found at human...Ch. 12 - On the graphs presented in Problem 21, no data is...Ch. 12 - Prob. 29PCh. 12 - Prob. 30PCh. 12 - In the 1920s, Barbara McClintock, later a Nobel...Ch. 12 - Give at least one example of a chromosomal...Ch. 12 - Cornelia de Lange syndrome CdLS is a rare human...Ch. 12 - a. Give at least three examples of types of...Ch. 12 - A number of yeast-derived elements were added to...Ch. 12 - Prob. 36PCh. 12 - The completely synthetic yeast chromosome Syn III...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Consider the following segment of DNA, which is part of a linear chromosome: LEFT 5’.…TGACTGACAGTC….3’ 3’.…ACTGACTGTCAG….5’ RIGHT During RNA transcription, this double-strand DNA molecule is separated into two single strands from the right to the left and the RNA polymerase is also moving from the right to the left of the segment. _____________ is the template strand for the synthesis of RNA? The sequence of the newly transcribed mRNA is _________________. Question 5 options: The top strand, 5'...GACUGUCAGUCA...3' The bottom strand, 5'...ACUCACUCUCAG...3' The top strand, 5'...UGACUGACAGUC...3' The bottom strand, 5'...GACUGUCAGUCA...3'arrow_forwardHistones form more accessible chromatin because of Select one: a. Reduced electrostatic attraction between the histone and the negatively charged DNA backbone b. Increased electrostatic attraction between the histone and the negatively charged DNA backbone c. Reduced covalent bonding between the histone and the negatively charged DNA backbone d. Increased covalent bonding between the histone and the negatively charged DNA backbonearrow_forwardWhich figure shows a chromatin structure that is most likely from a gene that is epigenetically silenced? A B OA Barrow_forward
- Euchromatin refers to regions of DNA that are loosely packed to increase the efficiency of transcription. Which of the following would you expect to find in a region of euchromatin? A. more thymines B. fewer thymines C. more histones D. fewer histonesarrow_forwardWhich of these is NOT true of nucleosomes? A. Some post-translational modifications to histone proteins serve as binding sites for transcription factors. B. The position of nucleosomes is fixed on the genome and can not be changed. C. The position and post-translational modifications of histones can be inherited through mitosis. D. The binding between DNA and histone proteins can be disrupted by post-translational modifications.arrow_forwardChanges in chromatin packing correlate with changes in gene expression in most cells. Why do you think this is the case?arrow_forward
- A mutant DNA strand was transcribed then translated to proteins. a. What is the protein product of the mutant DNA strand? The sequence of the mutant strand is shown below: 5'-TGCCATAACTGTTCGTACTGGCAAATTGCC-3' 3'-ACGGTATTGACAAGCATGACCGTTTAACGG-5' b. The mutation altered the sequence of the wild type template DNA such that a degenerate codon for a basic amino acid in the wild type was converted to a non-degenerate codon resulting in the sequence for the mutant strand shown. What was the original amino acid? c. Compare the charges and pl of the mutant peptide and the normal (wild- type) peptide at physiological pH?arrow_forwardFor each statement below indicate whether it is true or false: A. Strand discrimination during the process of DNA repair is based on DNA methylation B. The genetic code has 64 amino acid-specifying codons C. Mutations in germline cells are more consequential to subsequent generations than mutations in somatic cells.arrow_forwardYou add a chemical to a cell that prevents all of the chromatin from uncoiling so that the chromosomes remain highly coiled, even after the completion of mitosis. If you add a transcription factor that triggers the transcription of mRNA for the protein Pitx in this situation what would happen. Group of answer choices A)All transcription of Pitx is stopped by the transcription factor B)Nothing because the Pitx gene is already being transcribed at the maximum ratea C)Nothing, because the Pitx gene cannot be transcribed in this highly coild state D)The amount of transcription of Pitx is greatly increasedtarrow_forward
- Give at least one example of a chromosomal structureor function affected by the following mechanisms formodulating chromatin structure:a. Posttranslational changes of the normal histonesfound in the nucleosomearrow_forwardThe picture below depicts electron micrographs of the major levels of chromatin structure. Match each of the listed conditions with the most likely levels of chromatin structure under that condition.arrow_forwardWhich illustration below correctly depicts the effect of histone modification in chromatin remodeling? (Ac- acetyl group, -H3K9trimethylated)? Ac Ac AC AC AC A. m 2 Ac Ac Ac Ac B. C. Ac Ac H3K9trimethylated Ac Ac Acarrow_forward
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