Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 12, Problem 28P
On the graphs presented in Problem 21, no data is available for the region between coordinates 44 and 47 of chromosome 8. What kind of chromosome feature might this region represent? (Hint: It remains difficult for computer programs to assemble DNA sequences from regions containing large amounts of repetitive DNA.)
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Chapter 12 Solutions
Genetics: From Genes to Genomes
Ch. 12 - For each of the terms in the left column, choose...Ch. 12 - Many proteins other than histones are found...Ch. 12 - What difference exists between the compaction of...Ch. 12 - What is the role of the core histones in...Ch. 12 - a. About how many molecules of histone H2A would...Ch. 12 - The enzyme micrococcal nuclease can cleave...Ch. 12 - a. What letters are used to represent the short...Ch. 12 - About 2000 G bands are visible in a...Ch. 12 - Suppose you performed a fluorescence in situ...Ch. 12 - Which of the following would be suggested by a...
Ch. 12 - For each of the following pairs of chromatin...Ch. 12 - a. Drosophila b. Humans Give examples of...Ch. 12 - One histone modification that is seen consistently...Ch. 12 - Recently, scientists constructed a transgene that...Ch. 12 - Drosophila geneticists have isolated many...Ch. 12 - On the following figures, genes A and B are on the...Ch. 12 - Prob. 17PCh. 12 - The first page of this chapter displays photos of...Ch. 12 - The human genome contains about 3 billion base...Ch. 12 - The mitotic cell divisions in the early embryo of...Ch. 12 - In an experiment published in the journal Cell in...Ch. 12 - a. What DNA sequences are found at the telomeres...Ch. 12 - Prob. 23PCh. 12 - a. In a fluorescent in situ hybridization FISH...Ch. 12 - If you are comparing the two telomeres in each...Ch. 12 - a. What DNA sequences are commonly found at human...Ch. 12 - On the graphs presented in Problem 21, no data is...Ch. 12 - Prob. 29PCh. 12 - Prob. 30PCh. 12 - In the 1920s, Barbara McClintock, later a Nobel...Ch. 12 - Give at least one example of a chromosomal...Ch. 12 - Cornelia de Lange syndrome CdLS is a rare human...Ch. 12 - a. Give at least three examples of types of...Ch. 12 - A number of yeast-derived elements were added to...Ch. 12 - Prob. 36PCh. 12 - The completely synthetic yeast chromosome Syn III...
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- 1 3 3' T?L|| ?|||?| II|I |A|||T|||CL |||| 4 5 "A. Denote the 5' and 3' ends of all of the DNA strands in the figure noting that you are already given the 3' end of one of the strands." "B. What are the identities of the 6 bases marked by question marks at locations 1-6 for each chromosome? Note this is prior to any mismatch repair processes. Denote the correct identities on the figure or list them here." "C. Mark on the figure the regions of the DNA that is considered heteroduplex DNA if the Holliday junctions were resolved in the locations that they are currently depicted." "D. Assume that the Holliday junctions resolve so that there is no crossing over (that is, there is no recombination). For the maternal chromosome list all of the possible base identities at the three positions after the cell repairs any mismatches. Do the same for the paternal chromosome."arrow_forwardA typical eukaryotic chromosome found in humans has about 100 million bp of DNA. As noted in Chapter 11, 1 DNA base pair has a linear length of 0.34 nm.A. What is the linear length of the DNA in a typical human chromosomein micrometers?B. What is the linear length of a 30-nm fiber of a typical humanchromosome?C. Based on your calculation in part B, would a typical human chromosome fit inside the nucleus (with a diameter of 5 μm) if the 30-nm fiber were stretched out in a linear manner? If not, explain how a typical human chromosome fits inside the nucleus during interphase.arrow_forwardAssuming that the 30-nm chromatin fiber con-tains about 20 nucleosomes (200 bp/nucleosome) per 50nm of length, calculate the degree of compaction of DNAassociated with this level of chromatin structure. Whatfraction of the 10,000-fold condensation that occurs atmitosis does this level of DNA packing represent?arrow_forward
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