Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 12, Problem 18P
The first page of this chapter displays photos of Rainbow and her clone, CC. Both cats are tabby (their colored fur has a mottled pattern) and both have white regions, mainly on their bellies and legs. However, a major difference exists in their appearances. Rainbow is a calico tabby; she has black and orange spots controlled by alleles of the X-linked O gene, where the dominant trait is black (O-) and the recessive trait is orange (oo). However, Rainbow’s clone, CC, is a black tabby; she lacks the orange spots.
CC was made by transferring into an enucleated oocyte a single nucleus from one of Rainbow’s diploid somatic cells. That diploid oocyte, a mimic of a fertilized egg, was then implanted in the uterus of a surrogate mother. (The process of cloning by somatic cell nuclear transfer will be described in more detail in Chapter 18.)
| a. | What is Rainbow’s (and CC’s) genotype for the O gene?? |
| b. | Given that CC was made from a single one of Rainbow’s somatic cell nuclei, explain the difference between CC’s and Rainbow’s appearances. |
| c. | Would every clone of Rainbow’s c. be a black tabby like CC, or do other possibilities exist? Explain. |
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Duchenne muscular dystrophy is an X-linked, recessive disorder in which muscles waste away early in life, resulting in death in the teens or twenties. A man and woman in their late thirties have five children—three boys (ages 1, 3, and 10 years) and two girls (ages 5 and 7 years). The oldest, boy shows symptoms of the disease. What are the probabilities that their other children will develop the disease?
Give only typing answer with explanation and conclusion
Let’s suppose that two different X-linked genes exist in mice,designated with the letters N and L. Gene N exists in a dominant,normal allele and in a recessive allele, n, that is lethal. Similarly,gene L exists in a dominant, normal allele and in a recessive allele,l, that is lethal. Heterozygous females are normal, but males thatcarry either recessive allele are born dead. Explain whether or notit would be possible to map the distance between these two genesby making crosses and analyzing the number of living and deadoffspring. You may assume that you have strains of mice in whichfemales are heterozygous for one or both genes.
X-linked ichthyosis is an X-linked recessive trait that manifests in part as dry, scaly skin (“ichthy-” = fish or fish like). Suppose a couple are considering having a child together. Parent A is heterozygous for the ichthyosis allele while Parent B is hemizygous negative for the ichthyosis allele. What is the probability their child would be unafflicted with ichthyosis but be a carrier of the ichthyosis-causing allele?
a.0%
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Chapter 12 Solutions
Genetics: From Genes to Genomes
Ch. 12 - For each of the terms in the left column, choose...Ch. 12 - Many proteins other than histones are found...Ch. 12 - What difference exists between the compaction of...Ch. 12 - What is the role of the core histones in...Ch. 12 - a. About how many molecules of histone H2A would...Ch. 12 - The enzyme micrococcal nuclease can cleave...Ch. 12 - a. What letters are used to represent the short...Ch. 12 - About 2000 G bands are visible in a...Ch. 12 - Suppose you performed a fluorescence in situ...Ch. 12 - Which of the following would be suggested by a...
Ch. 12 - For each of the following pairs of chromatin...Ch. 12 - a. Drosophila b. Humans Give examples of...Ch. 12 - One histone modification that is seen consistently...Ch. 12 - Recently, scientists constructed a transgene that...Ch. 12 - Drosophila geneticists have isolated many...Ch. 12 - On the following figures, genes A and B are on the...Ch. 12 - Prob. 17PCh. 12 - The first page of this chapter displays photos of...Ch. 12 - The human genome contains about 3 billion base...Ch. 12 - The mitotic cell divisions in the early embryo of...Ch. 12 - In an experiment published in the journal Cell in...Ch. 12 - a. What DNA sequences are found at the telomeres...Ch. 12 - Prob. 23PCh. 12 - a. In a fluorescent in situ hybridization FISH...Ch. 12 - If you are comparing the two telomeres in each...Ch. 12 - a. What DNA sequences are commonly found at human...Ch. 12 - On the graphs presented in Problem 21, no data is...Ch. 12 - Prob. 29PCh. 12 - Prob. 30PCh. 12 - In the 1920s, Barbara McClintock, later a Nobel...Ch. 12 - Give at least one example of a chromosomal...Ch. 12 - Cornelia de Lange syndrome CdLS is a rare human...Ch. 12 - a. Give at least three examples of types of...Ch. 12 - A number of yeast-derived elements were added to...Ch. 12 - Prob. 36PCh. 12 - The completely synthetic yeast chromosome Syn III...
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- Hemophilia is another example of a X-linked disease caused when a recessive allele (Xh) is expressed. If a normal male reproduces with a heterozygous normal female, what are the expected genotypes and phenotypes? Will any of their daughters develop hemophilia? As in the previous question, you must also give the gender of the child in your genotype and phenotype descriptions here.arrow_forwardAnhidrotic ectodermal dysplasia is an X-linked recessive disorder in humans characterized by small teeth, no sweat glands, and sparse body hair. This trait is usually seen in men, but women who are heterozygous carriers of the trait often have irregular patches of skin with few or no sweat glands (see the illustration below). Q. Explain why women who are heterozygous carriers of a recessive gene for anhidrotic ectodermal dysplasia have irregular patches of skin lacking sweat glands.arrow_forwardIn humans, the genes for red-green color blindness (R = normal, r = color blind) and hemophilia A (H = normal, h = hemophilia) are both X-linked and only 3 map units apart. Suppose a woman has four sons, and two are color blind but have normal blood clotting and two have hemophilia but normal color vision. What is the probable genotype of the woman? HR/hr Hr/hr hr/hR Hr/hR HR/Hrarrow_forward
- In humans, red-green color-blindness is a recessive X-linked trait. A man with red-green color- blindness marries a normal-vision woman whose father was color-blind. As the genetic counselor, construct a Punnett square to determine the genotypic and phenotypic possibilities of their children. orange is due to heteroz means In human, assume that albinism is an autosomal recessive characteristic while hemophilia is X-linked recessive. An albino nonhemophiliac man has children with a normally-pigmented nonhemophiliac woman whose father was a hemophiliac and whose mother was albino. Calculate the phenotypes of the children they could produce.arrow_forwardHemophilia is another example of a X-linked disease caused when a recessive allele (Xh) is expressed. If a normal male reproduces with a heterozygous normal female, what are the expected genotypes and phenotypes? Will any of their daughters develop hemophilia? you must also give the gender of the child in your genotype and phenotype descriptions here.arrow_forwardAnhidrotic ectodermal dysplasia is an X-linked recessive disorder in humans characterized by small teeth, no sweat glands, and sparse body hair. This trait is usually seen in men, but women who are heterozygous carriers of the trait often have irregular patches of skin with few or no sweat glands (see the illustration below). a. Explain why women who are heterozygous carriers of a recessive gene for anhidrotic ectodermal dysplasia have irregular patches of skin lacking sweat glands. b. Why does the distribution of the patches of skin lacking sweat glands differ among the females depicted in the illustration, even between the identical twins?arrow_forward
- Please take a look at the attachment.arrow_forwardConsider a couple: a woman who is homozygous for a recessive mutation that causes X-linked colorblindness, and a man with full color vision (he does not carry a copy of the mutation). a) What is the probability that a son of this couple will be colorblind? b) What is the probability that a daughter of the couple will be colorblind?arrow_forwardA male has a particular X-linked recessive genetic disorder. His partner is normal, but her father had the disorder. What is the chance that their sons will have the disorder? Select one: Oa. 50% O b. 0% O c. 100% O d. impossible to determine from the information given. O e. 25% LENA C Transcribed Image Text: A male has a particular X-linked recessive genetic disorder. His partner is normal, but her father had the disorder. What is the chance that their sons will have the disorder? Select one: O a. 50% O b. 0% O c. 100% O d. impossible to determine from the information given. O e. 25% Po 11 W *****arrow_forward
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