Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 8, Problem 3TQ
Summary Introduction
To review:
The specificity of type I protein secretion system.
Introduction:
The design of the transport system shows great diversity due to selection pressure that helped to establish appropriate cell processes. The evolution of the new system occurs through gene mutation and accidental duplication of the gene. The simplest protein transport systems are Type I. They are the ATP- binding cassette (ABC) transporters.
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Students have asked these similar questions
According to the “Hawaiian Punch" principle, different compartments of the
secretory and endocytic pathways are topologically equivalent to each other and to
the extracellular space.
a) Explain how vesicular transport generates this topological equivalence.
b) During mitosis in mammalian cells, the nuclear envelope breaks down into
vesicles. Are the topological properties of the cell altered by this event? Justify
your answer.
Describe the mechanism by which endoplasmic reticulum vesicles fuse with the Golgi apparatus, with reference to the role of SNARE and Rab proteins
You are studying a cytoskeletal accessory protein, AB2. You believe it is involved in receptor-mediated endocytosis allowing for the entry of a novel virus, SARS-CoV X, into the host cell. To confirm
that AB2 is required for viral entry, you engineer an AB2 protein containing an N-terminal hydrophobic signal sequence and a C-terminal KDEL sequence (AB2-SSKDEL) and express it in human
epithelial airway cells.
You compare cells expressing wild-type (WT) AB2 (lacking the signal sequence and KDEL sequence) with cells expressing AB2-SSKDEL.
You are looking at the entry of a GFP (green) virus into cells.
If AB2 is required for viral entry, via receptor-mediated endocytosis, what results would you expect to see in terms of viral entry?
A. WT AB2 - Green ER
AB2-SSKDEL - No green ER
B. WT AB2-NO green cells
AB2-SSKDEL - Many green cells
OC. WT AB2 - Many green cells
AB2-SSKDEL - NO green cells
D.WT AB2 - Green nuclei
AB2-SSKDEL - No green nuclei
Chapter 8 Solutions
Microbiology: An Evolving Science (Fourth Edition)
Ch. 8.1 - Prob. 1TQCh. 8.1 - Prob. 2TQCh. 8.1 - Prob. 3TQCh. 8.3 - Prob. 1TQCh. 8.3 - Prob. 2TQCh. 8.3 - Prob. 3TQCh. 8.3 - Prob. 4TQCh. 8.3 - Prob. 5TQCh. 8.3 - Prob. 6TQCh. 8.3 - Prob. 7TQ
Ch. 8.3 - Prob. 8TQCh. 8.6 - Prob. 1TQCh. 8 - Prob. 1RQCh. 8 - Prob. 2RQCh. 8 - Prob. 3RQCh. 8 - Prob. 4RQCh. 8 - Prob. 5RQCh. 8 - Prob. 6RQCh. 8 - Prob. 7RQCh. 8 - Prob. 8RQCh. 8 - Prob. 9RQCh. 8 - Prob. 10RQCh. 8 - Prob. 11RQCh. 8 - Prob. 12RQCh. 8 - Prob. 13RQCh. 8 - Prob. 14RQCh. 8 - Prob. 15RQCh. 8 - Prob. 16RQCh. 8 - Prob. 17RQCh. 8 - Prob. 1TQCh. 8 - Prob. 2TQCh. 8 - Prob. 3TQ
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- The following questions refer to membrane protein isolation A) What is the difficulty when working with membrane proteins and extracting them from the membrane? B) Why do you need stabilization of membrane proteins? What reagents are used for stabilization? C) What methods are used to determine if your extracted membrane protein (GPCR) is functional? D) What methods are used for the enrichment of surface proteins? E) What 2 methods are used to analyze and identify surface proteins after extraction?arrow_forwardYou’ve made a 25 mM stock of colchicine (a tubulin inhibitor; dissolved in distilled water), which you’d like to use to study the effect of tubulin on phagocytosis in T.pyriformis. Based on published research articles that you’ve read, you’d like to preincubate T. pyriformis with colchicine at a final, effective concentration of 75 µM. Assuming you need 40 µL of the cell+colchicine mixture for your experiment, please explain how you can use your 25 mM solution of colchicine, T. pyriformis cells, and distilled water to create your cell+colchicine mixture.arrow_forwardThe figure above shows the organization of a protein that will eventually reside in the plasma membrane. The boxes labeled 1 and 2 represent membrane-spanning sequences and the arrow represents a site of action of signal peptidase. Which of the following statements must be TRUE about this protein? O a) Most of this protein will project from the cytosolic side of the membrane. O b) The mature version of this protein will span the membrane twice. c) This is a multi-pass membrane protein. O d) The mature version of this protein will span the membrane once.arrow_forward
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