Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 8, Problem 1TQ
Summary Introduction
To review:
The mechanism that releases positive supercoils in the DNA (Deoxyribonucleic acid) which help DNA polymerase to move along the DNA template during the transcription process.
Introduction:
Transcription is the process in which the DNA sequences of a gene are copied to produce RNA (Ribonucleic acid). RNA polymerase acts as the main transcription enzyme. The process of transcription proceeds in three stages: initiation, elongation, and termination. Initiation is the beginning of transcription, elongation is the
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What is the difference between the leading strand and the lagging strand in DNA replication?
There are different DNA polymerases involved in elongation of the leading strand and the lagging strand.
The leading strand is synthesized continuously in the 5' → 3' direction, while the lagging strand is synthesized discontinuously in the 5' → 3' direction.
The leading strand requires an RNA primer, whereas the lagging strand does not.
The leading strand is synthesized in the 3' → 5' direction in a discontinuous fashion, while the lagging strand is synthesized in the 5' → 3' direction in a continuous fashion.
DNA polymerases are processive, which means that they remain tightly associated with the
template strand while moving rapidly and adding nucleotides to the growing daughter
stand. Which piece of the replication machinery accounts for this characteristic?
Helicase
Sliding Clamp
Single Stranded Binding Protein
Primase
Which of the followings statements are true about DNA polymerase?
1.) It can only go in one direction, meaning the lagging strand can't be synthesized continuously.
2.) It cannot start a DNA strand from scratch, so another enzyme is needed to create "primers" as a starting point.
3.) It cannot copy epigenetic marks (such as methyl groups) on its own; these must be "copied" onto the daughter DNA strand by other enzymes after DNA replication.
4.) All of the above
Chapter 8 Solutions
Microbiology: An Evolving Science (Fourth Edition)
Ch. 8.1 - Prob. 1TQCh. 8.1 - Prob. 2TQCh. 8.1 - Prob. 3TQCh. 8.3 - Prob. 1TQCh. 8.3 - Prob. 2TQCh. 8.3 - Prob. 3TQCh. 8.3 - Prob. 4TQCh. 8.3 - Prob. 5TQCh. 8.3 - Prob. 6TQCh. 8.3 - Prob. 7TQ
Ch. 8.3 - Prob. 8TQCh. 8.6 - Prob. 1TQCh. 8 - Prob. 1RQCh. 8 - Prob. 2RQCh. 8 - Prob. 3RQCh. 8 - Prob. 4RQCh. 8 - Prob. 5RQCh. 8 - Prob. 6RQCh. 8 - Prob. 7RQCh. 8 - Prob. 8RQCh. 8 - Prob. 9RQCh. 8 - Prob. 10RQCh. 8 - Prob. 11RQCh. 8 - Prob. 12RQCh. 8 - Prob. 13RQCh. 8 - Prob. 14RQCh. 8 - Prob. 15RQCh. 8 - Prob. 16RQCh. 8 - Prob. 17RQCh. 8 - Prob. 1TQCh. 8 - Prob. 2TQCh. 8 - Prob. 3TQ
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- "Unlike what happens in DNA replication, where both strands are copied, only one of the two strands is transcribed into MRNA. The DNA strand that contains the gene is sometimes called the sense strand, or coding strand, and the DNA strand that gets transcribed to give RNA is called the antisense strand, or noncoding strand. Because the sense strand and the antisense strand are complementary, and because the DNA antisense strand and the newly formed RNA strand are also complementary, the RNA molecule produced during transcription is a copy of the DNA sense strand... The only difference is that the RNA molecule has a U everywhere the DNA sense strand has a T." Consider the following segment of a DNA sense strand: (5') CAA-ACT-ACG-GCG-TTG-CAG (3’)arrow_forwardWhat is the difference between DNA polymerase and RNA polymerase?arrow_forwardWhat type of enzyme is telomerase? DNA-directed DNA polymerase DNA-directed RNA polymerase RNA-directed DNA polymerase RNA-directed RNA polymerasearrow_forward
- What is the difference between DNA proofreading and DNA repair? In 3-4 sentencearrow_forwardIn DNA replication, the role of topoisomerase is to Question 11 options: a) "unzip" the double stranded DNA in front of DNA polymerase. b) maintain the single stranded DNA. c) supercoil the DNA after the replication fork has passed. d) relieve supercoil tension in the DNA in front of the replication fork.arrow_forwardDNA polymerase occasionally incorporates the wrong nucleotide during DNA replication. If left unrepaired, the base-pair mismatch that results will lead to mutation in the next replication. As part of a template strand, the incorporated wrong base will direct the incorporation of a base complementary to itself, so the bases on both strands of the DNA at that position will now be different from what they were before the mismatch event. The MER-minus strain of yeast does not have a functional mismatch excision repair system, but it has normal base excision repair and nucleotide excision repair systems. Which of the following statements is correct about differences in the mutation spectrum between MER-minus and wildtype yeast? More than one answer is correct. Options: More point mutations will arise in MER-minus yeast. Fewer point mutations will arise in MER-minus yeast as compared with wildtype. Of the total point mutations that…arrow_forward
- During DNA replication, DNA polymerase adds nucleotides to the: 3' end of the newly synthesized strand as it moves toward the 3' end of the template strand 3' end of the newly synthesized strand as it moves toward the 5'end of the template strand 5' end of the newly synthesized strand as it moves toward the 5' end of the template strand 5' end of the newly synthesized strand as it moves toward the 3' end of the template strand none of the above 0 0 0 0 0arrow_forwardClustered sites where replication of multiple DNA molecules takes place are called transcription factories. a) True b) Falsearrow_forwardDNA replication occurs by adding (Note: NTPS = nucleotide triphosphates; dNTPs = deoxynucleotide triphosphates) DNTPS to the 3' end of the template strand NTPS to the 3' end of the daughter strand DNTPS to the 3' end of the daughter strand DNTPS to the 5' end of the template strand NTPS to the 5' end of the daughter strandarrow_forward
- Lagging strand: is synthesized discontinuously in the replication fork. direction toward the N terminal to the C terminal From the nitrogenous base to the phosphate group 5-> 3' 3'-> 5 direction toward the Leading strand: is synthesized continuously in the replication fork. N terminal to the C terminal From the nitrogenous base to the phosphate group 5-> 3' O 3'-> 5' How would the DNA sequence GCTATA be transcribed to MRNA? GCUAUA CGATAT CGAUAU O GCUTUT What bases would be found on the other strand of the DNA sequence GCTATA ? GCUAUA CGATAT CGAUAU GCUTUT O O O O O OO OOarrow_forwardDuring DNA replication, why doesn’t DNA polymerase move away from the replication fork on both strands?arrow_forwardA DNA strand has the following sequence: 5’-GAACCCGATGGCGATACATTTACCAGATCACCAGC-3’ In which direction would DNA polymerase slide along this strand (from left to right or from right to left)? If this strand was used as a template by DNA polymerase, what would be the sequence of the newly made strand? Indicate the 5’ and 3’ ends of the newly made strand.arrow_forward
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