Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 11, Problem 32RQ
Summary Introduction
To review:
The structure of sphingomyelin and identification of hydrophilic and hydrophobic regions.
Introduction:
Sphingomyelins are found only inanimal cells. The major concentration of sphingomyelin is found in nerve tissues, but a small portion of it is also found in most tissues present in the body. It is also composed of the plasma membrane and plays a significant role in signaling pathways.
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Multisubunit proteins in which some or all of the subunitsare identical are referred to as _______________________.
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Chapter 11 Solutions
Biochemistry: The Molecular Basis of Life
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- The carrier of molecules of carbon dioxide in fatty acid synthesis is _____________.arrow_forwardIt is well known that sphingomyelin interacts with cholesterol and high affinity. What do you suppose is the structural basis for such interactions? Be specific.arrow_forwardProtease is an enzyme that catalyzes the breaking of amide bonds which is very stable at “mild” conditions, namely body temperature and pH 7 (if done in the lab requires hot conditions, concentrated HCl for hours). Some proteases have two aspartic acid residues at their active sites. Write the reaction mechanism (which follows general acid-base catalysis)arrow_forward
- A posttranslational modification that directs a polypeptide toa specific site is called a _____________________modification.arrow_forward_____________ is a disaccharide in which galactose is linked to glucose by a β-glycosidic linkage.arrow_forwardQuestion 11. // Hint: Isoelectric focusing separates proteins based on their pI values, and can separate proteins that only differ by a net charge of ±1.±1. Recall that an amino acid residue with a negatively charged R group has a relatively low isoelectric point (pI) where it has zero net charge. Likewise, an amino acid residue with a positively charged R group has a relatively high isoelectric point (pI) where it has zero net charge. Order from Low pH to High pHarrow_forward
- A metabolic pathway that functions in both anabolic andcatabolic processes is called an _____________________pathway.arrow_forwardOrotic aciduria is an autosomal recessive disease caused by a deficiency of the enzyme UMP synthase (a bifunctional protein composed of orotate pyrophosphoribosyl transferase and OMP decarboxylase activities). What symptom accounts for the disease’s name? Suggest a possible treatment.arrow_forwardOne of the main sources of sphingosine in the body is in the cell membrane. What complication could arise from the biological synthesis of ceramide?arrow_forward
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