Microbiology: An Evolving Science (Fourth Edition)
Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 24, Problem 15RQ
Summary Introduction

To review:

The differences between the classical and alternative pathways of complement activation.

Introduction:

The complement cascade is formed by a series of 20 proteins that are found in serum, they are also referred to as complement factors. This system attacks the bacterial invaders by inducing pores in their membranes and causing cytoplasmic leakage. Alternatively, this system can facilitate phagocytosis by white blood cells. The activation of complement system can be done by three pathways, the classical pathway, the alternative pathway, and the lectin pathway.

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Describe the control of the alternate pathway of complement activation.
Describe the mechanism of the classical complement pathway and discuss the critical role that the split products of C3 and other complement proteins play in the elimination of bacteria.
Contrast the pathways of complement activation.
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