Microbiology: An Evolving Science (Fourth Edition)
Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 24, Problem 10RQ
Summary Introduction

To review:

Isotype switching and the process of achieving antibody diversity.

Introduction:

Primary response occurs when an antigen gets in touch with the immune system for the very first time. During this response, the B cells are proliferated into the antibody-secreting plasma cells and memory B cells. The B-cell is programmed to produce primary antibody response and as a result, the pentameric IgM (Immunoglobulin M) molecule is synthesized and secreted. Later, a process called isotype switching occurs and the IgG antibody is produced from the predominant antibody type rather than IgM.

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