(a)
Interpretation:
The synthesis of fexofenadin has to be shown.
Concept introduction:
The Grignard reaction:
Alkyl, vinyl, or aryl-magnesium halides (
(b)
Interpretation:
The possible stereoisomer’s has to be shown if the product is chiral.
Concept introduction:
Isomer: A molecule having the same molecular formula but with different chemical structure is called isomer.
Enantiomers: A compound which is non-superimposable mirror image is called enantiomers.
Diastereomers: A compound which is non-superimposable and non-mirror image is called diastereomers.
Racemic mixture: A racemic mixture is simply a mixture containing an equal amount of each enantiomer.
Achiral:
A molecule is superimposable on its mirror image is called achiral molecule.
Want to see the full answer?
Check out a sample textbook solutionChapter 23 Solutions
Organic Chemistry
- Bisphenol A is widely used as a building block in polymer synthesis and is found in the polycarbonate hard plastics of reusable drink containers, DVDs, cell phones, and other consumer goods. Bisphenol A is reported to have estrogenic activity, and its widespread occurrence in our environment is a potential concern. Describe one or two biochemical experiments that could be done to compare the activity of bisphenol A with that of its estradiol, its structural relative.arrow_forwardWhy is methyl salicylate so easily absorbed through the skin?arrow_forwardN-Methylpyrrolidine has a boiling point of 81 °C, and piperidine has a boiling point of 106 °C. Tetrahydropyran has a boiling point of 88 °C, and cyclopentanone has a boiling point of 141 °C. These two isomershave a boiling point difference of 53 °C. Explain why the two oxygen-containing isomers have a much larger boilingpoint difference than the two amine isomersarrow_forward
- Oxytocin is a naturally occurring hormone that induces labor and stimulates milk production in nursing mothers. How many primary amides are present in oxytocin? NH₂ H₂N NH `N H ΝΗ O 3 O 4 07 08 O None of these HO ZI HN NH, S I oxytocin IZ H₂Narrow_forwardA simple, reversible competitive antagonist is expected to acutely: Reduce both the potency and efficacy of an agonist O Increase the potency of an agonist O Reduce the potency of an agonist Reduce the efficacy of an agonistarrow_forwardWhat chemical test will you use to differentiate acetanilide from aniline?arrow_forward
- 14 он (a) 1 но. но Statement 1: The present of primary amines in R1 contribute to the adrenergic activity Statement 2: Substitution of the hydroxyl group to the alpha-carbon decrease the alpha and beta-receptor agonist activity * Statement 1 is correct Statement 2 is correct Both statements are correct O Neither statment 1 nor statment 2 are correctarrow_forwardDiscuss the chemistry of histamine, antihistamines, and anti-ulcer drugsarrow_forwardA drug which has high affinity for muscarinic receptors not nicotinic receptors and is an antagonist not an agonist: Norepinephrine (LEVOPHED) O Atracurium (TRACURIUM) Echothiophate (PHOSPHOLINE) Ipratropium (ATROVENT) Norepinephrine (LEVOPHED) nint)arrow_forward
- The following structure is more active than morphine as an analgesic. HO -NMe H. acetyl O The extra acetyl group interacts with an extra binding region within the binding site by acting as a hydrogen bond acceptor O The extra acetyl group masks a polar group allowing the structure to cross cell membranes more efficiently O The extra acetyl group masks an alcohol group which would otherwise undergo a phase Il metabolic conjugation reaction leading to rapid excretion of the drug. O The extra acetyl group masks a polar group allowing the structure to cross the blood brain barrier more efficiently.arrow_forwardBenzodiazepines are known to have a wide therapeutic window. What makes benzodiazepines relatively safe even when consumed in higher than therapeutic doses?arrow_forwardWhat time of intermolecular interactions occur when the tertiary amine of Tapentadol binds to its drug target?arrow_forward
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage LearningIntroduction to General, Organic and BiochemistryChemistryISBN:9781285869759Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar TorresPublisher:Cengage LearningGeneral, Organic, and Biological ChemistryChemistryISBN:9781285853918Author:H. Stephen StokerPublisher:Cengage Learning
- Organic And Biological ChemistryChemistryISBN:9781305081079Author:STOKER, H. Stephen (howard Stephen)Publisher:Cengage Learning,Chemistry for Today: General, Organic, and Bioche...ChemistryISBN:9781305960060Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. HansenPublisher:Cengage LearningEBK A SMALL SCALE APPROACH TO ORGANIC LChemistryISBN:9781305446021Author:LampmanPublisher:CENGAGE LEARNING - CONSIGNMENT