Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 2, Problem 24CONQ
Summary Introduction
To analyze:
The pedigree for Marfan syndrome.
Introduction:
Marfan syndrome is a rarely found genetic disorder which involves problem associated with connecting tissues. People suffering from Marfan syndrome are found to be unusually tall. Life expectancy of such individuals used to be low but now it is almost same as that of normal individuals.
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Marfan syndrome is a rare inherited human disorder characterizedby unusually long limbs and digits plus defects in the heart (especially the aorta) and the eyes, among other symptoms. Following isa pedigree for this disorder. Affected individuals are shown withfilled (black) symbols. What type of inheritance pattern do youthink is the most likely?
The following pedigree shows the inheritance of Huntington’s disease, a fatal genetic disorder that causes neurodegeneration. Since signs and symptoms usually do not appear until adulthood, many who are carriers may not realize their risk of passing on the disease-causing allele. The following pedigree represents a family in which some people are affected by Huntington’s disease.
Using just the information on this pedigree, is Huntington’s disease caused by a dominant allele or recessive alleles?
What are the genotypes of the grandparents (I-1 and I-2)?
What are the genotypes of the parents (II-6 and II-7)?
If the parents above have another child, what is the chance that they will be affected by the Hungtington’s disease allele?
What are the genotypes of the unaffected children (III-8, 9, 10)?
What is the chance that the unaffected children above will pass on a Huntington’s disease allele to their children?
What is the genotype of the affected child (III-11)?
What is the chance…
O Huntington's Disease is a rare neurodegenerative disorder caused by a defective gene. A pedigree is shown
below with a family that is affected. Describe the pattern of inheritance that Huntington's Disease is following.
Justify your answer with reference to the diagram. Use proper notation (II-3, etc.) when referring to individuals.
II
2
3
6
8
II
1 2 3
4
5
7.
Chapter 2 Solutions
Genetics: Analysis and Principles
Ch. 2.1 - 1. Experimental advantages of using pea plants...Ch. 2.1 - The term cross refers to an experiment in which a....Ch. 2.1 - 3. To avoid self-fertilization in his pea plants,...Ch. 2.2 - Prob. 1COMQCh. 2.2 - Prob. 2COMQCh. 2.3 - A pea plant has the genotype rrYy. How many...Ch. 2.3 - A cross is made between a pea plant that is RrYy...Ch. 2.3 - Prob. 3COMQCh. 2.4 - Which of the following would not be observed in a...Ch. 2.4 - Prob. 2COMQ
Ch. 2.5 - A cross is made between AABbCcDd and AaBbccdd...Ch. 2.5 - Prob. 2COMQCh. 2.5 - Prob. 3COMQCh. 2 - 1. Why did Mendel’s work refute the idea of...Ch. 2 - 2. What is the difference between...Ch. 2 - 3. Describe the difference between genotype and...Ch. 2 - 4. With regard to genotypes, what is a...Ch. 2 - 5. How can you determine whether an organism is...Ch. 2 - In your own words, describe Mendels law of...Ch. 2 - Based on genes in pea plants that we have...Ch. 2 - Prob. 8CONQCh. 2 - Do you know the genotype of an individual with a...Ch. 2 - 10. A cross is made between a pea plant that has...Ch. 2 - Prob. 11CONQCh. 2 - 12. Describe the significance of nonparentals with...Ch. 2 - For the following pedigrees, describe what you...Ch. 2 - Ectrodactyly, also known as lobster claw syndrome,...Ch. 2 - Identical twins are produced from the same sperm...Ch. 2 - In cocker spaniels, solid coat color is dominant...Ch. 2 - A cross was made between a white male dog and two...Ch. 2 - 18. In humans, the allele for brown eye color (B)...Ch. 2 - Albinism, a condition characterized by a partial...Ch. 2 - A true-breeding tall plant was crossed to a dwarf...Ch. 2 - 21. For pea plants with the following genotypes,...Ch. 2 - 22. An individual has the genotypeand makes an...Ch. 2 - 23. In people with maple syrup urine disease, the...Ch. 2 - Prob. 24CONQCh. 2 - 25. A true-breeding pea plant with round and Page...Ch. 2 - Prob. 26CONQCh. 2 - 27. What are the expected phenotypic ratios from...Ch. 2 - Prob. 28CONQCh. 2 - Prob. 29CONQCh. 2 - A pea plant that is dwarf with green, wrinkled...Ch. 2 - 31. A true-breeding plant with round and green...Ch. 2 - Wooly hair is a rare dominant trait found in...Ch. 2 - Huntington disease is a rare dominant trait that...Ch. 2 - 34. A woman with achondroplasia (a dominant form...Ch. 2 - 1. Describe three advantages of using pea plants...Ch. 2 - Explain the technical differences between a...Ch. 2 - 3. How long did it take Mendel to complete the...Ch. 2 - 4. For all seven characters described in the data...Ch. 2 - From the point of view of crosses and data...Ch. 2 - 6. As in many animals, albino coat color is a...Ch. 2 - 7. The fungus Melampsora lini causes a disease...Ch. 2 - For Mendels data for the experiment in Figure 2.8,...Ch. 2 - 9. Would it be possible to deduce the law of...Ch. 2 - In fruit flies, curved wings are recessive to...Ch. 2 - A recessive allele in mice results in an unusally...Ch. 2 - Prob. 12EQCh. 2 - Prob. 13EQCh. 2 - Prob. 14EQCh. 2 - 15. A cross was made between two strains of plants...Ch. 2 - A cross was made between two pea plants, TtAa and...Ch. 2 - Consider this four-factor cross: TtRryyAaTtRRYyaa,...
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- Refer to the pedigree below which shows inheritance for achondroplasia (dwarfism), a dominantly inherited trait (denoted as D), which are the darkened circles and squares. Dwarfism (darkened shapes) are dominantly inherited, while normal height is recessively inherited (hh). Based on the pedigree, what is the correct genotype for individual #II-6? Dominant Autosomal Pedigree 2 II 2 3 II 1 2 3 6 9 10 Dd DD DD or Dd ddarrow_forwardRead the following family history and draw a pedigree to determine the inheritance pattern for achondroplasia. Once the pedigree is assembled , label the genotypes of each individual using a capital "A to represent the dominant allele and a lower case "a " to represent the recessive allele and create a key to identify which version is the achondroplasia allele. If you are unsure of the genotype , label the individual with a "" in place of the unknown allele. Family History : Jada and Noel , both of short stature, have been married for twenty years. They have three children : an eighteen - year-old boy named Shawn , of short stature ; a fifteen- year- old boy named John , of short stature ; and a twelve -year -old girl named Ann , of average height Noel and Jada also had a male child bom with severe achondroplasia who died six months after birth from respiratory failure . Noel's father was of short stature , while his mother was average height . Noel has a brother and a…arrow_forwardHypophosphatemia is a dominant genetic disorder caused by a deficiency of phosphates in the blood. Assuming the other parent is free of the disorder, males with the disorder will pass it on to all their daughters, but not their sons. Females with the disorder will pass it on to approximately half of their children. Is this pattern of inheritance autosomal or sex-linked? Draw Punnett squares to show the inheritance pattern of the disorder in each of the two scenarios.arrow_forward
- Below is a pedigree chart for a family that has a history of Alkaptonuria. Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications. Given this pedigree answer the following questions. Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive? What are the genotypes for #1, #2, and #3? If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype? Why or why not?arrow_forwardHemophilia is a sex-linked recessive trait. A male hemophiliac and phenotypically normal female have a son with hemophilia. They would like to have one more child. What is the probability of having a child without hemophilia? Explain using a Punnett square. Is it possible for a girl to be born with hemophilia? Explain.arrow_forwardPlease consider the following pedigree. Assume that people who marry in to the family do not carry the allele unless otherwise indicated. Assume complete penetrance. I II 5 6 III 6 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Provide a genotype for individual III-6 for the most likely mode of inheritance as determined in (a).arrow_forward
- Duchenne muscular dystrophy is a sex-linked recessive disorder characterized by a progressive loss of muscle tissue. Neither Carla nor Rudy has Duchenne muscular dystrophy, but their first son does have it. What can you say about Rudy's or Carla's genotype in relation with the disorder? If the couple has a second child, what is the probability that he or she will also have the disease? Show your answers with a Punnet square.arrow_forwardA young couple went to see a genetic counselor because each had a sibling affected with cystic fibrosis. (Cystic fibrosis is a recessive disease and neither member of the couple nor any of their four parents is affected). What is the probability that the female of this couple is a carrier and what are the chances that their child will be affected with cystic fibrosis?arrow_forwardSickle cell anemia is a human genetic disorder caused by an autosomal recessive allele. A couple plan to marry and want to know the probability that they will have an affected child. With your knowledge of Mendelian inheritance, what can you tell them if (1) each has one affected parent and a parent with no family history of SCA or (2) the man is affected by the disorder but the woman has no family history of SCA?arrow_forward
- Please consider the following pedigree. Assume that people who marry in to the family do not carry the allele. Assume complete penetrance. I II III 3 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Based strictly on the characteristic patterns of inheritance that define the four different options in (a), give a definitive motivation for the most likely mode of inhertance.arrow_forwardPorphyria is a genetic disorder caused by the inability to properly metabolize a component of hemoglobin. King George III is suspected to have been afflicted with this disorder. Assume that both George and his Queen suffered from this disorder and they had one afflicted child and one normal child. Is porphyria inherited in a dominant or recessive fashion? What must be the genotype of both George and his Queen? Using punnett square, show ALL work used to achieve your answer.arrow_forwardHuntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jane is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibits sickle cell anemia. What are the genotypes of Jane and Paul?arrow_forward
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