Porphyria is a genetic disorder caused by the inability to properly metabolize a component of hemoglobin. King George III is suspected to have been afflicted with this disorder. Assume that both George and his Queen suffered from this disorder and they had one afflicted child and one normal child. Is porphyria inherited in a dominant or recessive fashion? What must be the genotype of both George and his Queen? Using punnett square, show ALL work used to achieve your answer.

Porphyria is a genetic disorder caused by the inability to properly metabolize a component of hemoglobin. King George III is suspected to have been afflicted with this disorder. Assume that both George and his Queen suffered from this disorder and they had one afflicted child and one normal child. Is porphyria inherited in a dominant or recessive fashion? What must be the genotype of both George and his Queen? Using punnett square, show ALL work used to achieve your answer.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter5: The Inheritance Of Complex Traits

Section: Chapter Questions

Problem 23QP: If diseases such as cardiovascular disease (hypertension and atherosclerosis) are familial, is this...

See similar textbooks

Similar questions

Given the karyotype shown at right, is this a male or a female? Normal or abnormal? What would the phenotype of this individual be?
Mr. and Mrs. Smith are concerned because their own blood types are A and B, respectively, but their new son, Richard, is blood type O. Could Richard be the child of these parents?
Did the fact that Prince Albert and Queen Victoria were first cousins have anything to do with the fact that she carried the allele for hemophilia? Why or why not?
If diseases such as cardiovascular disease (hypertension and atherosclerosis) are familial, is this an indication that there is a genetic contribution to these traits? What would you do to confirm that genetics is involved in this condition?
Hemophilia is inherited as a sex-linked recessive trait. A non-hemophilic man marries a non-hemophilic woman whose father had hemophilia. With respect to this information, indicate all possible genotypes their children could possibly have. Show ALL work using punnett squares.
A couple who are a carrier of sickle-cell disease with blood type A for the female and type B for the male (assume heterozygosity for blood types). What is the probability that they will have a son with blood type B and is sickle- cell? Please show the solution.
Hemophilia is a sex-linked recessive trait. A male hemophiliac and phenotypically normal female have a son with hemophilia. They would like to have one more child. What is the probability of having a child without hemophilia? Explain using a Punnett square. Is it possible for a girl to be born with hemophilia? Explain.
Hemophilia is an X-linked disease associated with the inability to produce specific proteins in the blood-clotting pathway. Shown above is a family pedigree tree in which family members afflicted with the disease are shown with filled-in squares (male) or circles (females). A couple is trying to determine the likelihood of passing on the disease to their future children (represented by the ? symbol above) because the hemophilia runs in the woman’s family 4.Assuming that the woman in the couple is a carrier, what is the probability that the couple’s first son will have hemophilia?
Alpha thalassemia is a hereditary blood condition that results in varying levels of anemia. It is tied to the HB alpha 1 gene and the HB alpha 2 gene on human chromosome 16. The diagram shows the proteins for the hemoglobin genes and the pedigree shows genotypes, designated by the letter X, on the chromosomes for a family affected by the condition. Which represents the predicted level of anemia in a child born to the mother and father in the image with a mutation that results in a genotype of xxxx? Why? A - mild anemia because the loss of 4 genes would equal the loss of the 4 proteins needed for normal alpha hemoglobin B - severe anemia because the loss of 4 genes would equal the loss of the 4 proteins needed for normal alpha hemoglobin C - mild anemia because the addition of 4 genes would produce too many of the proteins needed for normal alpha hemoglobin D - severe anemia because the addition of 4 genes would produce too many of the proteins needed for normal alpha hemoglobin
Because Elsa has received a confirmed diagnosis of beta-thalassemia major, which of the following statements is true about her parents? Only her mother carried the gene that caused her blood disorder. Only her father carried the gene that caused her blood disorder. If her parents have another child naturally, there is a 100% chance that the second child will be diagnosed with beta-thalassemia major. If her parents have another child naturally, there is a 25% chance that the second child will be diagnosed with beta-thalassemia major.
Sickle cell anemia is caused by an individual carrying two recessive copies of the hemoglobin gene (hemoglobin gene is labeled Hb, and the recessive version is Hbs). Thus, to have sickle cell anemia, a person must have the genotype HbSHbS. A person that is HbAHbA carries two copies of the normal hemoglobin gene and does not have sickle cell anemia. A person that is heterozygous (HbAHbS) produces enough normal hemoglobin to not have sickle cell anemia but is also resistant to malaria. People that are heterozygous are called “carriers” because they carry the recessive allele but do not express the recessive phenotype. a. A couple are both resistant to malaria but do not have sickle cell anemia. Draw a Punnett square to represent this cross. b. What is the probability that the couple has three children where one child does not have a recessive allele, one child is resistant to malaria and does not have sickle cell anemia, and one child has sickle cell anemia?
Below is a pedigree chart for a family that has a history of Alkaptonuria. Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications. Given this pedigree answer the following questions. Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive? What are the genotypes for #1, #2, and #3? If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype? Why or why not?