Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 15.2, Problem 2COMQ
Summary Introduction
Introduction:
The modification of histones affects the level of transcription. These modification can either attract those proteins that initiate transcription or attract those proteins that inhibit transcription. This kind of regulation is important for the survival of an organism in different environmental conditions.
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Alternate splicing:
A. Reduces mRNA half-life by shortening
poly(A) tails
B. Disrupts histone arrangement for
increased transcription
C. Uses topoisomerase to complete its
function
D. Can produce 2 or more products from
one gene
Which of the following will lead to a decrease in transcription of a gene?
A. Increase in histone acetyltransferases.
B. Decrease in CpG methylation of promoter.
C. Increase in histone deacetylases.
D. Decrease in DNA methyltransferases.
Which of these is NOT true of nucleosomes?
A. Some post-translational modifications to histone proteins serve as binding sites for transcription factors.
B. The position of nucleosomes is fixed on the genome and can not be changed.
C. The position and post-translational modifications of histones can be inherited through mitosis.
D. The binding between DNA and histone proteins can be disrupted by post-translational modifications.
Chapter 15 Solutions
Genetics: Analysis and Principles
Ch. 15.1 - 1. Combinatorial control refers to the phenomenon...Ch. 15.1 - 2. A regulatory transcription factor protein...Ch. 15.1 - 3. A bidirectional enhancer has the following...Ch. 15.1 - 4. Regulatory transcription factors can be...Ch. 15.2 - 1. A chromatin-remodeling complex may
a. change...Ch. 15.2 - Prob. 2COMQCh. 15.2 - 3. Which of the following characteristics is...Ch. 15.2 - 4. Transcriptional activation of eukaryotic genes...Ch. 15.3 - How can methylation affect transcription? a. It...Ch. 15.3 - 2. The process in which completely unmethylated...
Ch. 15.4 - Prob. 1COMQCh. 15.5 - The overall goal of the ENCODE Project is a. to...Ch. 15.6 - The binding of iron regulatory protein (IRP) to...Ch. 15 - Discuss the common points of control in eukaryotic...Ch. 15 - 2. Discuss the structure and function of...Ch. 15 - 3. What is meant by the term transcription factor...Ch. 15 - What are the functions of transcriptional...Ch. 15 - 5. Is each of the following statements true or...Ch. 15 - 6. Transcription factors usually contain one or...Ch. 15 - Prob. 7CONQCh. 15 - Prob. 8CONQCh. 15 - 9. Let’s suppose a mutation in the glucocorticoid...Ch. 15 - Prob. 10CONQCh. 15 - Prob. 11CONQCh. 15 - Prob. 12CONQCh. 15 - 13. Transcription factors such as the...Ch. 15 - An enhancer, located upstream from a gene, has the...Ch. 15 - 15. The DNA-binding domain of each CREB protein...Ch. 15 - The gene that encodes the enzyme called tyrosine...Ch. 15 - Prob. 17CONQCh. 15 - 18. What is a histone variant?
Ch. 15 - Prob. 19CONQCh. 15 - 20. What is meant by the term histone code? With...Ch. 15 - Prob. 21CONQCh. 15 - Histones are thought to be displaced as RNA...Ch. 15 - 23. What is an insulator? Describe two different...Ch. 15 - 24. What is DNA methylation? When we say that DNA...Ch. 15 - Lets suppose that a vertebrate organism carries a...Ch. 15 - 26. What is a CpG island? Where would you expect...Ch. 15 - Describe how the binding of iron regulatory...Ch. 15 - 1. Briefly describe the method of chromatin...Ch. 15 - Researchers can isolate a sample of cells, such as...Ch. 15 - Prob. 3EQCh. 15 - Prob. 4EQCh. 15 - Prob. 5EQCh. 15 - 6. As described in Chapter 21, an electrophoretic...Ch. 15 - Prob. 7EQCh. 15 - 1. Explain how DNA methylation could be used to...Ch. 15 - 2. Enhancers can occur almost anywhere in DNA and...
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- Which of the following may produce more than one functional protein from an mRNA transcript?a. chromatin condensation b. transcriptional regulation c. epigeneticsd. alternative mRNA processingarrow_forwardPost-translational modifications of proteins can affect which of the following? a. protein function b. transcriptional regulation c. chromatin modification d. all of the abovearrow_forwardWhich of the following best explains how the prokaryotic expression of a metabolic protein can be regulated when the protein is already present at a high concentration? a.Repressor proteins can be activated and bind to regulatory sequences to block transcription. b.Regulatory proteins can be inactivated to increase gene expression. c.Transcription factors can bind to regulatory sequences to increase RNA polymerase binding. d.Histone modification can prevent transcription of the gene.arrow_forward
- Which of the following is the best description of a transcription factor? A. A protein that brings the correct nucleotides to RNA polymerase B. A protein that binds to specific DNA sequences C. A DNA sequence that binds to RNA polymerase D. A modification that is made to mRNA to help it be exported from the nucleus. .arrow_forwardWhich of the following is an example of chromatin modification that stimulates gene expression? Group of answer choices A. alternative exon splicing b. microRNA binding to mRNA c. DNA methylation D. histone acetylationarrow_forwardFor each statement below indicate whether it is true or false: A. Strand discrimination during the process of DNA repair is based on DNA methylation B. The genetic code has 64 amino acid-specifying codons C. Mutations in germline cells are more consequential to subsequent generations than mutations in somatic cells.arrow_forward
- For each of the following, identify the type of RNA involved (mRNA, rRNA, or tRNA). a. Transports the correct amino acid to the ribosome, using the information encoded in the mRNA. b. Is a major component of ribosomes. c. Specifies the order of amino acids in a protein, using a series of three-base codons, where different amino acids are specified by particular codons. d. Contains a three-base anticodon that pairs with a complementary codon revealed in the mRNA. e. Assists in making the bonds that link amino acids together to make a protein.arrow_forwardChanges in a cell that affect micro RNAs lead to cancer because miRNAs... a. help a cell to maintain a tight control on protein levels in a cell. b. decrease the level of a specific protein. c. increase the level of a specific protein. d. prevent the Warburg effect.arrow_forwardIn prokaryotes, control of gene expression usually occurs at the a. splicing of pre-mRNA into mature mRNA. b. initiation of translation. c. initiation of transcription. d. All of the choices are correct.arrow_forward
- Within a cell, the amount of protein made using a given mRNA molecule depends partly on A. the presence of certain transcription factors. B. the rate at which the mRNA is degraded. C. the degree of DNA methylation. D. the number of introns present in the mRNA. please explain which is correct and incorrect and whyarrow_forwardFor each statement about gene expression mechanisms, choose the correct end to the sentence. For each gene, the template strand for transcription is determined by…. The direction of translation is determined by…… The tissue-specificity of protein production is determined by…. choices: a. location of the start codon b. location of the promoter c. direction of polymerization by RNA polymerase d. none of these e. direction of movement of ribosomes f. overall orientation of the chromosomearrow_forwardWhich of the following is not true regarding gene regulation that involves DNA bending? a. The precise distance between the regulatory sequence and the promoter is important. b. Effect can be to repress transcription c. Effect can be to activation transcription d. Regulated genes can be thousands of base pairs away from the regulatory sitesarrow_forward
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