Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 15.2, Problem 2COMQ
Summary Introduction
Introduction:
The modification of histones affects the level of transcription. These modification can either attract those proteins that initiate transcription or attract those proteins that inhibit transcription. This kind of regulation is important for the survival of an organism in different environmental conditions.
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Alternate splicing:
A. Reduces mRNA half-life by shortening
poly(A) tails
B. Disrupts histone arrangement for
increased transcription
C. Uses topoisomerase to complete its
function
D. Can produce 2 or more products from
one gene
Which of the following will lead to a decrease in transcription of a gene?
A. Increase in histone acetyltransferases.
B. Decrease in CpG methylation of promoter.
C. Increase in histone deacetylases.
D. Decrease in DNA methyltransferases.
Which of the following may produce more than one functional protein from an mRNA transcript?a. chromatin condensation b. transcriptional regulation c. epigeneticsd. alternative mRNA processing
Chapter 15 Solutions
Genetics: Analysis and Principles
Ch. 15.1 - 1. Combinatorial control refers to the phenomenon...Ch. 15.1 - 2. A regulatory transcription factor protein...Ch. 15.1 - 3. A bidirectional enhancer has the following...Ch. 15.1 - 4. Regulatory transcription factors can be...Ch. 15.2 - 1. A chromatin-remodeling complex may
a. change...Ch. 15.2 - Prob. 2COMQCh. 15.2 - 3. Which of the following characteristics is...Ch. 15.2 - 4. Transcriptional activation of eukaryotic genes...Ch. 15.3 - How can methylation affect transcription? a. It...Ch. 15.3 - 2. The process in which completely unmethylated...
Ch. 15.4 - Prob. 1COMQCh. 15.5 - The overall goal of the ENCODE Project is a. to...Ch. 15.6 - The binding of iron regulatory protein (IRP) to...Ch. 15 - Discuss the common points of control in eukaryotic...Ch. 15 - 2. Discuss the structure and function of...Ch. 15 - 3. What is meant by the term transcription factor...Ch. 15 - What are the functions of transcriptional...Ch. 15 - 5. Is each of the following statements true or...Ch. 15 - 6. Transcription factors usually contain one or...Ch. 15 - Prob. 7CONQCh. 15 - Prob. 8CONQCh. 15 - 9. Let’s suppose a mutation in the glucocorticoid...Ch. 15 - Prob. 10CONQCh. 15 - Prob. 11CONQCh. 15 - Prob. 12CONQCh. 15 - 13. Transcription factors such as the...Ch. 15 - An enhancer, located upstream from a gene, has the...Ch. 15 - 15. The DNA-binding domain of each CREB protein...Ch. 15 - The gene that encodes the enzyme called tyrosine...Ch. 15 - Prob. 17CONQCh. 15 - 18. What is a histone variant?
Ch. 15 - Prob. 19CONQCh. 15 - 20. What is meant by the term histone code? With...Ch. 15 - Prob. 21CONQCh. 15 - Histones are thought to be displaced as RNA...Ch. 15 - 23. What is an insulator? Describe two different...Ch. 15 - 24. What is DNA methylation? When we say that DNA...Ch. 15 - Lets suppose that a vertebrate organism carries a...Ch. 15 - 26. What is a CpG island? Where would you expect...Ch. 15 - Describe how the binding of iron regulatory...Ch. 15 - 1. Briefly describe the method of chromatin...Ch. 15 - Researchers can isolate a sample of cells, such as...Ch. 15 - Prob. 3EQCh. 15 - Prob. 4EQCh. 15 - Prob. 5EQCh. 15 - 6. As described in Chapter 21, an electrophoretic...Ch. 15 - Prob. 7EQCh. 15 - 1. Explain how DNA methylation could be used to...Ch. 15 - 2. Enhancers can occur almost anywhere in DNA and...
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- Which of these is NOT true of nucleosomes? A. Some post-translational modifications to histone proteins serve as binding sites for transcription factors. B. The position of nucleosomes is fixed on the genome and can not be changed. C. The position and post-translational modifications of histones can be inherited through mitosis. D. The binding between DNA and histone proteins can be disrupted by post-translational modifications.arrow_forwardHDAC's are important enzymes involved in the regulation of Gene expression. This is because a. They create the Z form of DNA by removing acetyl groups from cytosines. b. they create euchromatic structure by adding acetyl groups to cytosine. c. they add methyl groups from histones creating less gene expression. d. they remove acetyl groups from histones creating less gene expression. e. they add methyl groups onto cytosines on DNA and create a heterochromatic structure.arrow_forwardPost-translational modifications of proteins can affect which of the following? a. protein function b. transcriptional regulation c. chromatin modification d. all of the abovearrow_forward
- Which of the following statament is NOT TRUE about gene expression?a. The expression of genes that code for proteins includes two stages: replication and translationb. Translation is the synthesis of a polypeptide using the information in the mRNA.c. During gene expression, the information encoded in genes is used to make specific polypeptide chains or RNA molecules.d. Gene expression is the process by which DNA directs the synthesis of proteinsarrow_forwardWhich of the following best explains how the prokaryotic expression of a metabolic protein can be regulated when the protein is already present at a high concentration? a.Repressor proteins can be activated and bind to regulatory sequences to block transcription. b.Regulatory proteins can be inactivated to increase gene expression. c.Transcription factors can bind to regulatory sequences to increase RNA polymerase binding. d.Histone modification can prevent transcription of the gene.arrow_forwardWhich of the following is true for both prokaryotic and eukaryotic gene expression? A. After transcription, a 3' poly-A tail and a 5' cap are added to MRNA. B. Translation of MRNA can begin before transcription is complete. C. RNA polymerase binds to the promoter region to begin transcription. D. MRNA is synthesized in the 3' → 5' direction.arrow_forward
- Each of the following statements about protein synthesis is false.Correct each to make a true statement. a. In a gene, each nucleotide specifies one amino acid in a protein sequence. b. A transcription factor must bind to the promoter region of a gene before the enzyme DNA synthetase is able to bind and begin transcription. c. The enzyme RNA polymerase builds a strand of transfer RNA, whose codons are complementary to DNA’s triplets. d. Proteins destined for secretion from the cell enter the nucleus after translation, to be folded and modified. e. During translation, amino acids are delivered by the messenger RNA transcriparrow_forwardWhich of the following is the best description of a transcription factor? A. A protein that brings the correct nucleotides to RNA polymerase B. A protein that binds to specific DNA sequences C. A DNA sequence that binds to RNA polymerase D. A modification that is made to mRNA to help it be exported from the nucleus. .arrow_forwardImagine that mutations occurred in one of the inverted repeat sequences within the rho-independent terminator sequence of a bacterium. What would likely be the consequence of this mutation? Select one: a. Transcription may not be initiated at all. b. Transcription may end prematurely. c. Transcription may be delayed. d. The rho protein won't be able to bind and transcription may not be terminate. e. Transcription may not be terminated and result in much longer RNA.arrow_forward
- Which of the following are steps of transcription? Select all that apply. a.RNA polymerase assembles a strand of mRNA complementary to the noncoding strand of DNA. b.RNA polymerase binds to a gene’s promoter. c.RNA polymerase assembles a strand of mRNA complementary to the coding strand of DNA. d.RNA polymerase moves over the gene and unzips the double helix to form a “transcription bubble.”arrow_forwardWhich of the following is an example of chromatin modification that stimulates gene expression? Group of answer choices A. alternative exon splicing b. microRNA binding to mRNA c. DNA methylation D. histone acetylationarrow_forwardThe function of the genetic code is toa. promote transcription.b. specify the amino acids within a polypeptide.c. alter the sequence of DNA.d. none of the abovearrow_forward
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