Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 15, Problem 17CONQ
Summary Introduction
To review:
Three ways in which ATP (adenosine triphosphate) dependent chromatin remodeling complexes may change chromatin structure.
Introduction:
The interconversion of closed and open conformations of chromatin are identified by several geneticists in recent years. In the cells where genes are active, nucleosomes show different positions, which express a particular gene.
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Describe how chromatin-remodeling complexes alter nucleosomes.
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Chapter 15 Solutions
Genetics: Analysis and Principles
Ch. 15.1 - 1. Combinatorial control refers to the phenomenon...Ch. 15.1 - 2. A regulatory transcription factor protein...Ch. 15.1 - 3. A bidirectional enhancer has the following...Ch. 15.1 - 4. Regulatory transcription factors can be...Ch. 15.2 - 1. A chromatin-remodeling complex may
a. change...Ch. 15.2 - Prob. 2COMQCh. 15.2 - 3. Which of the following characteristics is...Ch. 15.2 - 4. Transcriptional activation of eukaryotic genes...Ch. 15.3 - How can methylation affect transcription? a. It...Ch. 15.3 - 2. The process in which completely unmethylated...
Ch. 15.4 - Prob. 1COMQCh. 15.5 - The overall goal of the ENCODE Project is a. to...Ch. 15.6 - The binding of iron regulatory protein (IRP) to...Ch. 15 - Discuss the common points of control in eukaryotic...Ch. 15 - 2. Discuss the structure and function of...Ch. 15 - 3. What is meant by the term transcription factor...Ch. 15 - What are the functions of transcriptional...Ch. 15 - 5. Is each of the following statements true or...Ch. 15 - 6. Transcription factors usually contain one or...Ch. 15 - Prob. 7CONQCh. 15 - Prob. 8CONQCh. 15 - 9. Let’s suppose a mutation in the glucocorticoid...Ch. 15 - Prob. 10CONQCh. 15 - Prob. 11CONQCh. 15 - Prob. 12CONQCh. 15 - 13. Transcription factors such as the...Ch. 15 - An enhancer, located upstream from a gene, has the...Ch. 15 - 15. The DNA-binding domain of each CREB protein...Ch. 15 - The gene that encodes the enzyme called tyrosine...Ch. 15 - Prob. 17CONQCh. 15 - 18. What is a histone variant?
Ch. 15 - Prob. 19CONQCh. 15 - 20. What is meant by the term histone code? With...Ch. 15 - Prob. 21CONQCh. 15 - Histones are thought to be displaced as RNA...Ch. 15 - 23. What is an insulator? Describe two different...Ch. 15 - 24. What is DNA methylation? When we say that DNA...Ch. 15 - Lets suppose that a vertebrate organism carries a...Ch. 15 - 26. What is a CpG island? Where would you expect...Ch. 15 - Describe how the binding of iron regulatory...Ch. 15 - 1. Briefly describe the method of chromatin...Ch. 15 - Researchers can isolate a sample of cells, such as...Ch. 15 - Prob. 3EQCh. 15 - Prob. 4EQCh. 15 - Prob. 5EQCh. 15 - 6. As described in Chapter 21, an electrophoretic...Ch. 15 - Prob. 7EQCh. 15 - 1. Explain how DNA methylation could be used to...Ch. 15 - 2. Enhancers can occur almost anywhere in DNA and...
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- Which of the following statements most accurately represent chromatin state and transcription? Group of answer choices 1.Histone deacetylases promote closed chromatin and result in repressed transcription 2.Open chromatin is associated with hypoacetylation and has high levels of transcription 3.Histone acetyltransferases result in hypoacetylation and high levels of transcription 4.Hyperacetylation is associated with closed chromatin and low levels of transcriptionarrow_forwardDefine chromatin-mediated repression.arrow_forwardGive at least one example of a chromosomal structureor function affected by the following mechanisms formodulating chromatin structure:a. Posttranslational changes of the normal histonesfound in the nucleosomearrow_forward
- Genes are not always active in cells. The cell has evolved to edit its chromatin state in accord with the energy needs of the cell and organism. What are these two kinds of chromatin called and how does chromatin modeling work in cells? Name four of the known families of chromatin remodeling complexes enzyme complexes that act directly on DNA to alter nucleosome composition in transcribed regions.arrow_forwardHow chromatin remodeling and chromatin modifications are necessary to make cis-acting regulatory sequences accessible to binding ?arrow_forwardDescribe how chromatin remodeling complexes allowgene expression to occur.arrow_forward
- Briefly describe how mitotic recombination can result in loss of heterozygosity (LOH) at tumor suppressor gene loci.arrow_forwardExplain the chromatin remodeling complexes ?arrow_forwardThe localization of Ase1 and the phenotype of its deletion imply that this protein binds to anti-parallel Microtubules. What would you expect for the organization of a protein that has this property?arrow_forward
- What is chromatin remodeling complex?arrow_forwardDescribe how reversible chemical changes to DNA and histones are linked to chromatin modification.arrow_forwardRather surprisingly, some cellular components that we know best from our study of nuclear protein traffic also appear to be involved in the process of spindle assembly. These include Ran GEF (which, as you may recall, is bound to chromatin – an association that apparently continues even when the nuclear envelope breaks down at the onset of mitosis) and importin-β. Now think back to the process of nuclear protein import. To which form of Ran (Ran-GDP or Ran-GTP) does importin-β bind and what is the significance of that interaction with respect to the efficiency of delivery of import “cargo” to the nucleus? To which form of Ran (Ran-GDP or Ran-GTP) do exportins bind and what is the significance of that interaction with respect to the efficiency of delivery of export “cargo” to the cytoplasm?arrow_forward
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