Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 15, Problem 1QSDC
Explain how DNA methylation could be used to regulate gene expression in a tissue-specific way. When and where would de novo methylation occur, and when would demethylation occur? What would occur in the cells that give rise to eggs and sperm?
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Explain how DNA methylation can regulate gene expression in a tissue-specific way. When and where would de novo methylation occur,and when would demethylation occur? What would occur in the cellsthat give rise to eggs and sperm?
(a) How does the duplication of individual genes occur?
(b) individual that inherit a genetic condition known as xeroderma pigmentosum exhibit an extreme sensitivity to sunlight exposure and often develop skin cancer by the age of 10. What repair pathway is most likely disrupted as a result of such mutation? Explain why?
Explain how DNA methylation and the formation of a DNA loop control the expression of the Igf2 gene in mammals. How is this gene imprinted so that only the paternal copy is expressed in offspring?
Chapter 15 Solutions
Genetics: Analysis and Principles
Ch. 15.1 - 1. Combinatorial control refers to the phenomenon...Ch. 15.1 - 2. A regulatory transcription factor protein...Ch. 15.1 - 3. A bidirectional enhancer has the following...Ch. 15.1 - 4. Regulatory transcription factors can be...Ch. 15.2 - 1. A chromatin-remodeling complex may
a. change...Ch. 15.2 - Prob. 2COMQCh. 15.2 - 3. Which of the following characteristics is...Ch. 15.2 - 4. Transcriptional activation of eukaryotic genes...Ch. 15.3 - How can methylation affect transcription? a. It...Ch. 15.3 - 2. The process in which completely unmethylated...
Ch. 15.4 - Prob. 1COMQCh. 15.5 - The overall goal of the ENCODE Project is a. to...Ch. 15.6 - The binding of iron regulatory protein (IRP) to...Ch. 15 - Discuss the common points of control in eukaryotic...Ch. 15 - 2. Discuss the structure and function of...Ch. 15 - 3. What is meant by the term transcription factor...Ch. 15 - What are the functions of transcriptional...Ch. 15 - 5. Is each of the following statements true or...Ch. 15 - 6. Transcription factors usually contain one or...Ch. 15 - Prob. 7CONQCh. 15 - Prob. 8CONQCh. 15 - 9. Let’s suppose a mutation in the glucocorticoid...Ch. 15 - Prob. 10CONQCh. 15 - Prob. 11CONQCh. 15 - Prob. 12CONQCh. 15 - 13. Transcription factors such as the...Ch. 15 - An enhancer, located upstream from a gene, has the...Ch. 15 - 15. The DNA-binding domain of each CREB protein...Ch. 15 - The gene that encodes the enzyme called tyrosine...Ch. 15 - Prob. 17CONQCh. 15 - 18. What is a histone variant?
Ch. 15 - Prob. 19CONQCh. 15 - 20. What is meant by the term histone code? With...Ch. 15 - Prob. 21CONQCh. 15 - Histones are thought to be displaced as RNA...Ch. 15 - 23. What is an insulator? Describe two different...Ch. 15 - 24. What is DNA methylation? When we say that DNA...Ch. 15 - Lets suppose that a vertebrate organism carries a...Ch. 15 - 26. What is a CpG island? Where would you expect...Ch. 15 - Describe how the binding of iron regulatory...Ch. 15 - 1. Briefly describe the method of chromatin...Ch. 15 - Researchers can isolate a sample of cells, such as...Ch. 15 - Prob. 3EQCh. 15 - Prob. 4EQCh. 15 - Prob. 5EQCh. 15 - 6. As described in Chapter 21, an electrophoretic...Ch. 15 - Prob. 7EQCh. 15 - 1. Explain how DNA methylation could be used to...Ch. 15 - 2. Enhancers can occur almost anywhere in DNA and...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- examine the process of gene expression. Include the following: Explain the regulation of gene expression in eukaryotic cells. Discuss mechanisms by which gene expression may be altered. How do these alterations induce cancer-causing mutations in cell DNA? Explain how cancer is formed. Describe genetic changes found in cancer cells and how these changes lead to alterations in cell behavior. Determine whether proteome data can be utilized in genetic disorder diagnosis. Relate the Human Genome Project data to the analysis of cancer genes. Relates the Human Genome Project's utility in pharmacogenomics and personalized medicine to diagnose and treat cancerarrow_forwardYou are interested in the effects of mutations on the expression of a human protein- encoding gene expressed in skin cells. The gene has one intron that is 450 nucleotides long. After this intron is removed from the pre-mRNA, the mRNA transcript is 1100 nucleotides in length. Diploid somatic cells have two copies of this gene. Predict the size and amount of mRNA from the cytosol of skin cells, which were obtained from the following individuals: • Individual 1: Normal individual with no mutations in this gene. • Individual 2: Homozygous for a deletion that removes the -10 to -100 region of the gene that encodes this mRNA. • Individual 3: Heterozygous in which one gene is normal and the other gene has a deletion that removes the -10 to -100 region. • Individual 4: Homozygous for a five-nucleotide deletion in the intron that removes the GT sequence at the 5' splice site. Explain your answers.arrow_forwardAt the molecular level, how do you think a gain-of-function mutation in a developmental gene might cause it to be expressed in the wrong place or at the wrong time? Explain what type of DNA sequence would be altered.arrow_forward
- Do mutations that cause cancer in an individual pass down to his/her offspring? What is the role of proto-oncogenes and tumor-suppressor genes in cancer formation and development? Explain the connection between telomerase activity and cancer.arrow_forwardHow does a normal cell become a cancerous cell? What has to happen to it? Do mutations that cause cancer in an individual pass down to his/her offspring? What is the role of proto-oncogenes and tumor-suppressor genes in cancer formation and development? Explain the connection between telomerase activity and cancer.arrow_forwardHow is the expression of genes controlled at the chromosomal level? A. DNA can synthesize extra histones as needed B. DNA can either be condensed into heterochromatin or decondensed into euchromatin C. DNA can be unwound into euchromatin to reduce the level of expression D. The expression of DNA can only be controlled at the transcriptional level E. DNA is spontaneously deleted from a chromosome if not neededarrow_forward
- In the gene in the fruit fly (Drosophila) called antennepedia. It controls the formation of which structures? What happens when it is mutated?arrow_forwardExplain how epigenetic modifications are involved in developmentalchanges that lead to the formation of specific cell types.arrow_forwardDistinguish between mutations in somatic cells versus in germ cells.arrow_forward
- Explain how methylation of cytosine nucleotides can affect gene expression in one way. Explain how methylation of histone proteins can affect gene expression in one way.arrow_forwardDiscuss how the differential gene expression is possible when all somatic cells carry identical genes and genome.arrow_forwardow does DNA methylation occur? What enzyme is involved in DNA methylation? What are the consequences of DNA methylation? What is base flipping and why is it significant? How do bacteria use methylation to protect their own DNA? How is methylation is used to silence genes in plants and mammals? What is epigenetic silencing? How is DNA methylation involved in X-chromosome inactivation and genomic imprinting in mammals? What are boundary elements and what role do they play in separating chromatin domains? How do special DNA sites facilitate the transition between euchromatin and heterochromatin? How do boundary elements affect chromatin modification? How do boundary elements function by binding specific proteins? What are the elements required for chromosome function? List the specialized regions that direct essential chromosomal functions. How does the “origin” site initiate DNA replication? Why is a replication of linear DNA more complicated than the replication of circular DNA?arrow_forward
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QCE Biology: Introduction to Gene Expression; Author: Atomi;https://www.youtube.com/watch?v=a7hydUtCIJk;License: Standard YouTube License, CC-BY