Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 15.6, Problem 1COMQ
The binding of iron regulatory protein (IRP) to the iron response element (IRE) in the 5′ region of the ferritin mRNA results in the
a. inhibition of translation of the ferritin mRNA.
b. stimulation of translation of the ferritin mRNA.
c. degradation of the ferritin mRNA.
d. both a and c.
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Students have asked these similar questions
The binding of iron regulatory protein (IRP) to the iron response element (IRE) in the 5′ region of the ferritin mRNA results in the
a. inhibition of translation of the ferritin mRNA.
b. stimulation of translation of the ferritin mRNA.
c. degradation of the ferritin mRNA.
d. both a and c.
Arrange the statements in their proper order by writing the corresponding letter
(e.g. A) for each statement in the space provided below.
A. The single-stranded RNA would complement the target RNA.
B. Gene expression is inactivated once the mRNA is no longer accessible for
translation.
C. The risk-induced silencing complex which is composed of RNA and protein
subunits is formed.
D. Double-stranded, non-coding RNA is cleaved by Dicer.
E. The mRNA can be cleaved or remain bound by the RISC.
1.
2.
3.
4.
5.
Mature human insulin is synthesized from a single Gene but contains two polypeptide
chains (A and B) linked by disulfide bonds. Which of the following statements about the
A and B chains provides the best explanation for the production of human insulin?
a. They are identical and combine to form the mature insulin
b. They are produced by proteolytic processing of a single translation product
d.
c. They are the products of alternative translation-initiation sites on a single mRNA
They are the product of a separate A- and B-chain mRNA produced by
alternative splicing
e. They are the products of separate A- and B-chain mRNA synthesized from
alternative promoters
Chapter 15 Solutions
Genetics: Analysis and Principles
Ch. 15.1 - 1. Combinatorial control refers to the phenomenon...Ch. 15.1 - 2. A regulatory transcription factor protein...Ch. 15.1 - 3. A bidirectional enhancer has the following...Ch. 15.1 - 4. Regulatory transcription factors can be...Ch. 15.2 - 1. A chromatin-remodeling complex may
a. change...Ch. 15.2 - Prob. 2COMQCh. 15.2 - 3. Which of the following characteristics is...Ch. 15.2 - 4. Transcriptional activation of eukaryotic genes...Ch. 15.3 - How can methylation affect transcription? a. It...Ch. 15.3 - 2. The process in which completely unmethylated...
Ch. 15.4 - Prob. 1COMQCh. 15.5 - The overall goal of the ENCODE Project is a. to...Ch. 15.6 - The binding of iron regulatory protein (IRP) to...Ch. 15 - Discuss the common points of control in eukaryotic...Ch. 15 - 2. Discuss the structure and function of...Ch. 15 - 3. What is meant by the term transcription factor...Ch. 15 - What are the functions of transcriptional...Ch. 15 - 5. Is each of the following statements true or...Ch. 15 - 6. Transcription factors usually contain one or...Ch. 15 - Prob. 7CONQCh. 15 - Prob. 8CONQCh. 15 - 9. Let’s suppose a mutation in the glucocorticoid...Ch. 15 - Prob. 10CONQCh. 15 - Prob. 11CONQCh. 15 - Prob. 12CONQCh. 15 - 13. Transcription factors such as the...Ch. 15 - An enhancer, located upstream from a gene, has the...Ch. 15 - 15. The DNA-binding domain of each CREB protein...Ch. 15 - The gene that encodes the enzyme called tyrosine...Ch. 15 - Prob. 17CONQCh. 15 - 18. What is a histone variant?
Ch. 15 - Prob. 19CONQCh. 15 - 20. What is meant by the term histone code? With...Ch. 15 - Prob. 21CONQCh. 15 - Histones are thought to be displaced as RNA...Ch. 15 - 23. What is an insulator? Describe two different...Ch. 15 - 24. What is DNA methylation? When we say that DNA...Ch. 15 - Lets suppose that a vertebrate organism carries a...Ch. 15 - 26. What is a CpG island? Where would you expect...Ch. 15 - Describe how the binding of iron regulatory...Ch. 15 - 1. Briefly describe the method of chromatin...Ch. 15 - Researchers can isolate a sample of cells, such as...Ch. 15 - Prob. 3EQCh. 15 - Prob. 4EQCh. 15 - Prob. 5EQCh. 15 - 6. As described in Chapter 21, an electrophoretic...Ch. 15 - Prob. 7EQCh. 15 - 1. Explain how DNA methylation could be used to...Ch. 15 - 2. Enhancers can occur almost anywhere in DNA and...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- A geneticist induces a mutation in eukaryote cells. The mutation results in an inability to form the poly(A) tail during processing of pre-mRNA. What does this mean for the mature mRNA and what will be the effect on these cells? Possible Answers: A. The mRNA will be spliced, but will not have a 5' cap. B. The mRNA will likely be degraded. C. The mRNA will not be cleaved. D. The mRNA will have too many Gs and Cs.arrow_forwardThe primary function of 5' & 3' end mRNA modification is: a. To ensure that phosphorylation of the nucleotides b. Protection from nucleolytic degradation c. Assurance of end joining during nuclear export. d. To activate removal of introns e. All of the above.arrow_forwardWhich of the following is true of ribosome rescue? (C & E wrong) A. The process produces a protein that is tagged for degradation. B. Proteases enter the A-site of the ribosome to degrade the C-terminus of the synthesized peptide. C. A partially translated mRNA becomes fully degraded before it can be translated further. D. No protein is produced in the process. E. Stalled ribosomes are released in the absence of a stop codon.arrow_forward
- Differential RNA splicing may result in: a. A shift in the ratio of mRNA produced from two neighboring genes b. Inversion of exons in the mature mRNA c. Production of the same protein from two different genes d. Production of two different proteins with different properties from a single genearrow_forwardWhich of the following consequences of mutations would likely to be associated with an increased cancer risk? (select all that apply)? A. Truncation of the EGF receptor B. Constitutive activation of K-Ras C. Amplification of myc D. Truncation of H-Ras due to a premature stop codon E. Amplification of ErbB2arrow_forwardAre the following statements TRUE or FALSE?a. Post-transcriptional RNA processing occurs in the cytoplasm of the cell.b. A primary RNA transcript is often much longer than the mature mRNA that leaves the nucleus.c. Both ends of a pre-mRNA are modified to facilitate RNA splicing.arrow_forward
- The process of RNA interference may lead toa. the degradation of an mRNA.b. the inhibition of translation of an mRNA.c. the synthesis of an mRNA.d. both a and b.arrow_forwardWhich of the following best explains how the prokaryotic expression of a metabolic protein can be regulated when the protein is already present at a high concentration? a.Repressor proteins can be activated and bind to regulatory sequences to block transcription. b.Regulatory proteins can be inactivated to increase gene expression. c.Transcription factors can bind to regulatory sequences to increase RNA polymerase binding. d.Histone modification can prevent transcription of the gene.arrow_forwardWhich of the following statements is INCORRECT? a. In simultaneous transcription of mRNA, many messenger RNA may be transcribed from different DNA strand happening all at once. b. All of the following statements are incorrect c. A poly A - tail is added at the end of the 3’ base. d. In eukaryotic cells, messenger RNA must exit the nucleus and enter the cytoplasmarrow_forward
- Suppose hemoglobin is inhibited at the post-translational level. This means is it regulated at the _____ Select one: a. DNA level and mRNA will not be made b. tRNA level and protein will not be made c. mRNA level and the protein will not be made d. protein level and it will be inactive e. precursor mRNA level and mature mRNA will not be madearrow_forwardWhich of the following is not a function of the 5’ cap and 3’ poly-A tail of a mature eukaryotic mRNA molecule? a. To facilitate splicing b. To prevent mRNA degradation c. To aid export of the mature transcript to the cytoplasm d. To aid ribosome binding to the transcriptarrow_forwardHistone deacetylase (HDAC) enzymes a.Promote initiation of translation. b.Complex with hyperphosphorylated pRb. c.Repress E2F family activity. d.Add acetyl groups to E2F promoters. e.Promote initiation of transcription.arrow_forward
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