Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 4, Problem 24CONQ
Let’s suppose you have pedigree data from thousands of different families involving a particular genetic disease. How would you decide whether the disease is inherited as a recessive trait as opposed to one that is dominant but shows incomplete penetrance?
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The pedigree below shows three generations of a family that carries albinism, an autosomal recessive genetic disease. In the third generation, a child was born with albinism but the genotypes of the rest of the family are unknown. No other family members have the disease. Assume normal, Mendelian genetics with no new mutations. What are the genotypes of the parents of the affected child?
A) There is not enough information to determine their genotypes
B) Both are homozygous for albinism
C) One is hemizygous and one is heterozygous for albinism
D) Both are heterozygous for albinism
E) One is homozygous and one is heterozygous for abinism
Cystic fibrosis (CF) is an autosomal recessive trait. A three-generation pedigree is shown below for a family that carries the mutant allele for cystic fibrosis. Note that carriers are not colored in to allow you to figure out their genotypes. Normal allele = F CF mutant allele = f
What is the genotype of individual #13?
A) ff
B) FF
C) Ff
D) it is impossible to tell
For the pedigrees below, name the inheritance pattern of the depicted disorder: If more than one pattern is possible,
name all possibilities. For any recessive disorder, clearly mark all individuals who must be carriers by placing a dot inside
the corresponding circle or square. Assume that each disorder is rare (i.e. any individual "marrying into" the pedigree is
normal and not carrying a mutant allele).
A) I
II
III
IV
C) I
II
III
IV
1 2
E)
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I
II
III
IV
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D)
I
II
III
IV
II
III
IV
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2
Chapter 4 Solutions
Genetics: Analysis and Principles
Ch. 4.1 - 1. Which of the following statements is true?
a....Ch. 4.2 - 1. Which of the following is not an example of a...Ch. 4.2 - Prob. 2COMQCh. 4.2 - 3. Polydactyly is a condition in which a person...Ch. 4.3 - The outcome of an individuals traits is controlled...Ch. 4.4 - Prob. 1COMQCh. 4.4 - Prob. 2COMQCh. 4.5 - Prob. 1COMQCh. 4.5 - Hemophilia is a blood-clotting disorder in humans...Ch. 4.6 - Prob. 1COMQ
Ch. 4.7 - 1. The Manx phenotype in cats is caused by a...Ch. 4.8 - Which of the following is a possible explanation...Ch. 4.9 - 1. Two different strains of sweet peas are...Ch. 4.9 - If the F1 offspring from question 1 are allowed to...Ch. 4 - 1. Describe the differences among dominance,...Ch. 4 - Discuss the differences among sex-influenced,...Ch. 4 - 3. What is meant by a gene interaction? How can a...Ch. 4 - Lets suppose a recessive allele encodes a...Ch. 4 - 5. A nectarine is a peach without the fuzz. The...Ch. 4 - 6. An allele in Drosophila produces a star-eye...Ch. 4 - A seed dealer wants to sell four-oclock seeds that...Ch. 4 - 8. The blood serum from one individual (let’s call...Ch. 4 - 9. Which blood type phenotypes (A, B, AB, and/or...Ch. 4 - A woman with type B blood has a child with type O...Ch. 4 - A type A woman is the daughter of a type O father...Ch. 4 - In Shorthorn cattle, coat color is controlled by a...Ch. 4 - In chickens, the Leghorn variety has white...Ch. 4 - Propose the most likely mode of inheritance...Ch. 4 - 15. A human disease known as vitamin D-resistant...Ch. 4 - 16. Hemophilia is an X-linked recessive trait in...Ch. 4 - 17. Incontinentia pigmenti, a rare, X-linked...Ch. 4 - 18. Scurs in cattle is a sex-influenced trait. A...Ch. 4 - In rabbits, the color of body fat is controlled by...Ch. 4 - Prob. 20CONQCh. 4 - 21. The trait of feathering in fowls is a...Ch. 4 - Based on the pedigree shown here for a trait...Ch. 4 - 23. The pedigree shown here involves a trait...Ch. 4 - Lets suppose you have pedigree data from thousands...Ch. 4 - Prob. 25CONQCh. 4 - 26. In humans, a very rare dominant allele that...Ch. 4 - 27. A sex-influenced trait in humans affects the...Ch. 4 - Three coat-color patterns that occur in some...Ch. 4 - Prob. 1EQCh. 4 - 2. In chickens, some varieties have feathered...Ch. 4 - 3. In sheep, the formation of horns is a...Ch. 4 - Prob. 4EQCh. 4 - In the clover butterfly, males are always yellow,...Ch. 4 - The Mic2 gene in humans is present on both the X...Ch. 4 - 7. Duroc Jersey pigs are typically red, but a...Ch. 4 - 8. As shown in Figure 4.17, coat color in rodents...Ch. 4 - 9. Summer squash exist in long, spherical, or disk...Ch. 4 - In a species of plant, two genes control flower...Ch. 4 - 11. Red eyes is the wild-type phenotype in...Ch. 4 - 12. As mentioned in Experimental Question E11, red...Ch. 4 - Lets suppose you were looking through a vial of...Ch. 4 - 14. When examining a human pedigree, what features...Ch. 4 - Lets suppose a gene exists as a functional...Ch. 4 - In oats, the color of the chaff is determined by a...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- The pedigree shows a family in which several members have suffered from one and the same disease (look at the picture to be able to answer) a) Is it a dominant or recessive allele that causes the disease? Motivate your answer. b) Is allele autosomal or sex-linked? Motivate your answer. c) What is the probability that III-3 and III-4 will have a healthy child? Motivate your answer.arrow_forwardIn pedigrees, individuals are usually specified by using a Roman numeral for their generation in the chart and an Arabic number for their position (reading left to right) within that generation. If we use the letter c for the allele that causes cystic fibrosis, what are the genotypes of individuals III-3 and III-4 (the third and fourth individuals shown in generation III) in the pedigree that shows this disease?arrow_forwardThe pedigree below traces the inheritance of Albinism, a genetic disorder. Affected individuals, indicated here by the colored gray circles and squares, are unable to make a normal amount of melanin, the chemical that is responsible for eye, skin, and hair color. Does Albinism appear to be caused by a dominant allele or by a recessive allele? Fill in the genotypes of the individuals whose genotypes can be deduced. What genotypes are possible for each of the other individuals? Explain!arrow_forward
- If a geneticist were to closely examine the make-up of a single autosomal chromosome from one of your cells, that chromosome would be found to be a mosaic of genes derived from your mother and father. a mosaic of genes derived from just two of your grandparents-either your maternal grandparents or your paternal grandparents. a mosaic of genes derived from all four of your grandparents. a mosaic of genes derived from just two of your grandparents-either your two grandfathers or your two grandmothers. derived entirely from genes from just one of your grandparents.arrow_forwardThe attached image is a pedigree of a family with a history of sickle cell anemia (the individuals with the filled-in symbols have the disease and no new mutations are occurring in any individual). Sickle cell anemia is inherited in an autosomal recessive manner. What is the probability that the individual with the question mark (?) will get the disease? a) 1/4 b) 1/2 c) 2/3 d) 1arrow_forwardOne family is shown in both pedigrees below. Each pedigree focuses on a different monogenic, fully penetrant phenotype. Shaded individuals affected by Phenotype 1: 3 Shaded individuals affected by Phenotype 2: a. Phenotype 1: Which modes of inheritance can be ruled out, base don't this pedigree? For each mode of inheritance listed below, either state that it is not ruled out, or describe a detail of the pedigree that allows you to rule it out. Autosomal recessive Autosomal dominant X-linked recessive X-linked dominant Y-linked b. Phenotype 2: Which modes of inheritance can be ruled out, base don't this pedigree? For each mode of inheritance listed below, either state that it is not ruled out, or describe a detail of the pedigree that allows you to rule it out. Autosomal recessive Autosomal dominant X-linked recessive X-linked dominantarrow_forward
- Using the pedigree chart, explain: a) The number of generations seen. b) If all blue-coloured shapes are affected with disease X- how many males are affected? how many females are affected? c) Does this disease have a dominant or recessive inheritance pattern? Justify your answer.arrow_forwardHow many affected females and males does this pedigree show? (2) Who is the proband? (3) How many generations are included? (4) What kind of inheritance pattern is the disease-causing allele in this pedigree? Why? (5) Who have the same genotype as the proband? Why?arrow_forwardTay-Sachs is a recessive lethal disease in which there is neurological deterioration early in life. This disease is rare in the population overall but is found at relatively high frequency in Ashkenazi Jews from Eastern Europe. A woman has a maternal uncle who had the disease. Her father does not come from a high-risk population. Her husband’s sister died of the disease at an early age. Draw the pedigree of the individuals described. Include the genotypes where possible.arrow_forward
- In humans, albinism (lack of skin pigment) is an autosomal recessive trait. The first child of two normally pigmented parents is an albino. Which of the following is true about this family? SELECT ALL THAT ARE CORRECT. A) Their first child (described above) has a homozygous recessive genotype B) The next child born to this couple has a 25% chance of being albino. C) If the next child born to this couple is male, he has a greater chance of being albino. D) The parents are both heterozygous for albinism. E) The probability of their second child being albino is 0% F) If the second and third child born to this couple are albino, the fourth child has 100% chance of also being albino.arrow_forwardRed-green color blindness is inherited as an X-linked recessive (Xc). If a color-blind man marries a woman who is heterozygous for normal vision, what would be the expected phenotypes of their children with reference to this character? In your answer, specify in your phenotype descriptions the gender of the children. (For example, don’t just say 75% of the children would be colorblind – you would instead say 100 % of the daughters would be colorblind and 50% of the sons would be colorblind. Note that this is not a correct answer; it is just to give you an idea of how to explain the correct phenotypes of the cross.)___arrow_forwardEctrodactyly is a rare condition in which the fingers are absent and the hand is split. This condition is usually inherited as an autosomal dominant trait. Ademar Freire-Maia reported the appearance of ectrodactyly in a family in São Paulo, Brazil, whose pedigree is shown here. Is this pedigree consistent with autosomal dominant inheritance? If not, what mode of inheritance is most likely? Explain your reasoning.arrow_forward
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