Introduction to Genetic Analysis
11th Edition
ISBN: 9781464109485
Author: Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Publisher: W. H. Freeman
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Question
Chapter 3, Problem 11P
Summary Introduction
To determine: The principle resulting in the inheritance of mitochondrial disease from affected fathers.
Introduction: Some genetic information is perpetually transferred to offspring through mothers and never fathers. Infrequently, a mother provides an unaffected child owing to cytoplasmic division in the gamete forming tissue.
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From the pedigree in Figure 3-25, what principle can youdeduce about the inheritance of mitochondrial diseasefrom affected fathers?
Which of the pedigrees shown above could be one showing the inheritance of a non-lethal mitochondrial disease?
This is a typical pedigree for a family that carries neurofibromatosis.
Is individual I-2 most likely homozygous or heterozygous? Why? Explain.
Chapter 3 Solutions
Introduction to Genetic Analysis
Ch. 3 - Prob. 1PCh. 3 - Prob. 2PCh. 3 - Prob. 4PCh. 3 - Prob. 5PCh. 3 - Prob. 6PCh. 3 - Prob. 7PCh. 3 - Prob. 10PCh. 3 - Prob. 11PCh. 3 - Prob. 12PCh. 3 - Prob. 13P
Ch. 3 - Prob. 14PCh. 3 - Prob. 15PCh. 3 - Prob. 16PCh. 3 - Prob. 17PCh. 3 - Prob. 18PCh. 3 - Prob. 19PCh. 3 - Prob. 20PCh. 3 - Prob. 21PCh. 3 - Prob. 22PCh. 3 - Prob. 23PCh. 3 - Prob. 24PCh. 3 - Prob. 25PCh. 3 - Prob. 26PCh. 3 - Prob. 27PCh. 3 - Prob. 28PCh. 3 - Prob. 29PCh. 3 - Prob. 30PCh. 3 - Prob. 31PCh. 3 - Prob. 31.1PCh. 3 - Prob. 31.2PCh. 3 - Prob. 31.3PCh. 3 - Prob. 31.4PCh. 3 - Prob. 31.5PCh. 3 - Prob. 31.6PCh. 3 - Prob. 31.7PCh. 3 - Prob. 31.8PCh. 3 - Prob. 31.9PCh. 3 - Prob. 31.10PCh. 3 - Prob. 31.11PCh. 3 - Prob. 31.12PCh. 3 - Prob. 31.13PCh. 3 - Prob. 31.14PCh. 3 - Prob. 31.15PCh. 3 - Prob. 32PCh. 3 - Prob. 33PCh. 3 - Prob. 34PCh. 3 - Prob. 35PCh. 3 - Prob. 36PCh. 3 - Prob. 37PCh. 3 - Prob. 38PCh. 3 - Prob. 39PCh. 3 - Prob. 40PCh. 3 - Prob. 41PCh. 3 - Prob. 42PCh. 3 - Prob. 43PCh. 3 - Prob. 44PCh. 3 - Prob. 45PCh. 3 - Prob. 46PCh. 3 - Prob. 48PCh. 3 - Prob. 49PCh. 3 - Prob. 50PCh. 3 - Prob. 51PCh. 3 - Prob. 52PCh. 3 - Prob. 53PCh. 3 - Prob. 54PCh. 3 - Prob. 57P
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- The following pedigree illustrates the inheritance of a rare neurologicaldisease. What is the most likely mode of inheritance for this disorder?Explain your reasoning.arrow_forwardFor this pedigree, give the most likely mode of inheritance, assuming that the trait is rare. For the pedigree, what is the probability that III-4 and III-5 will have a boy AND he will be affected?arrow_forwardExplain why it is possible for the proband in the following pedigree to have children of blood types A, B, and AB. Considering epistatic genes, what are the possible genotypes of II-2?arrow_forward
- What is the mode of inheritance of this pedigree and why?arrow_forwardThis pedigree depicts the inheritance of the mitochondrial disease Leber hereditary optic neuropathy (LHON). Individual I-1 does not show any symptoms of LHON, whereas her daughter and all three of her grandchildren are affected. Provide two explanations for this.arrow_forwardIn pedigrees, individuals are usually specified by using a Roman numeral for their generation in the chart and an Arabic number for their position (reading left to right) within that generation. If we use the letter c for the allele that causes cystic fibrosis, what are the genotypes of individuals III-3 and III-4 (the third and fourth individuals shown in generation III) in the pedigree that shows this disease?arrow_forward
- The following family pedigree shows individuals afflicted with a metabolic disease. Suppose the male (b) and the female (c) have 2 girls and 2 boys, indicate directly on the pedigree the symbols for these children that would be most consistent with the mode of inheritance observations in the pedigree? II II a b d e IVarrow_forwardShown below is a pedigree for Phenylketonuria (PKU), an autosomal recessive metabolic disorder. The characteristic feature of PKU is severe mental retardation A) What is the probability that individual II-1 is heterozygous for this gene? B) What is the probability that individual III-4 is heterozygous for this gene? C) If individuals III-3 and III-4 were to marry, what is the probability that their child would express PKU?arrow_forwardFor the following cross, show the P generation Genotypes and the Phenotypic ratio that would be seen in the F1 and F2. Remember, to produce the F2 generation you want to cross Heterozygotes from the F1. d) Genes 1 and 2 exhibit Epistasis (9:6:1) and Gene 3 is an Autosomal Dominant. In the P generation, the Male is Homozygous Recessive for the Genes showing Epistasis. Use E1, E2 and E3 to represent the Phenotypes shown by Epistasis. Report your results in the following format: P = aabb x AABB, F1 = 100%AaBb (Phenotype), and %3! F2 = 9/16 A_B_ (Phenotype), 3/16 aaB (Phenotype), 3/16 A_bb (Phenotype), 1/16 aabb (Phenotype)arrow_forward
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