The following family pedigree shows individuals afflicted with a metabolic disease. Suppose the male (b) and the female (c) have 2 girls and 2 boys, indicate directly on the pedigree the symbols for these children that would be most consistent with the mode of inheritance observations in the pedigree? II II a b d. e IV

What is the MOST likely mode of inheritance of the trait shown in the pedigree, assuming that the trait is relatively rare in the general population and fully penetrant? III IV 1234 Selected Answer: autosomal dominant 10 11 12 13 14 15 5678

2 8. 5 6. 10 IV 3 4. 5 8. 10 11 12 13 14 Which of the following best describes the trait in the pedigree? OX-linked dominant OX-linked recessive O autosomal domiant O autosomal recessive 2)

A family tree of sorts is called a pedigree. The symbols used for a pedigree are: female, unaffected female, affected ☐male, unaffected male, affected I 11 III 1 Pedigree Chart Minor Peta #2 Siblings are placed in hirth order from left to right and are labeled with Arabic numerals. Each generation is labeled with a Roman numeral. Therefore, the male exhibiting the trait in the pedigree below in the bottom, center would be identified as III-4. 1. Which members of the family above are affected by Huntington's Disease? 4. How many girls did II-1 and 11-2 have? 3. How many children did individuals 1-1 and 1-2 have? 2. There are no carriers for Huntington's Disease- you either have it or you don't. With this in mind, is Huntington's disease caused by a dominant or recessive trait? 5. How are individuals III-2 and II-4 related? 8 -Huntington's Disease