Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 20, Problem 17PDQ
Although the capture and trading of great apes has been banned in 112 countries since 1973, it is estimated that about 1000 chimpanzees are removed annually from Africa and smuggled into Europe, the United States, and Japan. This illegal trade is often disguised by simulating births in captivity. Until recently, genetic identity tests to uncover these illegal activities were not used because of the lack of highly polymorphic markers (markers that vary from one individual to the next) and the difficulties of obtaining chimpanzee blood samples. A study was reported in which DNA samples were extracted from freshly plucked chimpanzee hair roots and used as templates for PCR. The primers used in these studies flank highly polymorphic sites in human DNA that result from variable numbers of tandem
Examine the data carefully and choose the best conclusion.
- (a) None of the offspring are legitimate.
- (b) Offspring B and C are not the products of these parents and were probably purchased on the illegal market. The data are consistent with offspring A being legitimate.
- (c) Offspring A and B are products of the parents shown, but C is not and was therefore probably purchased on the illegal market.
- (d) There are not enough data to draw any conclusions. Additional polymorphic sites should be examined.
- (e) No conclusion can be drawn because “human” primers were used.
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Some individuals in a canine population is susceptible to disease X, which strikes the
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dominant over the r allele, such that the rr individuals are susceptible to the disease and the
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genotype. Also, an independent estimation showed that mutation rate converting R to r is 5
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selection balance (MSB). If your hypothesis of MSB is true, then what is the survival rate
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where
%3D
u is the mutation rate and s is the selection coefficient.)
5%
50%
95%
99%
None of the above
Suppose a geneticist is using a three-point test cross to map three linked rabbit morphology and behavioral mutations called si,
It, and Le. The gene si is associated with the silky fur phenotype, and It is associated with the long-tailed phenotype. Both si and
It are recessive mutations with respect to wild type. Le is a dominant mutation that confers the lethargic phenotype.
The geneticist first crosses true-breeding lethargic rabbits to true-breeding silky fur, long-tailed rabbits. Next, the geneticist
backcrosses the Fj progeny to the silky fur, long-tailed parents, and obtains the results reported in the table.
Phenotype
Number
lethargic
815
silky fur, long-tailed
807
long-tailed
177
silky fur, lethargic
179
silky fur
7
long-tailed, lethargic
5
silky fur, long-tailed, lethargic
29
wild type
29
Place the genes in the correct order in the chromosome.
Answer Bank
si
It
Le
Tay−−Sachs disease is an autosomal recessive neurological disorder that is fatal in infancy. Despite its invariably lethal effect, Tay−−Sachs disease occurs at very high frequency in some Central and Eastern European (Ashkenazi) Jewish populations. In certain Ashkenazi populations, 1 in 800 infants has Tay−−Sachs disease. Population biologists believe the high frequency is a consequence of genetic bottlenecks caused by pogroms (genocide) that have reduced the population multiple times in the last several hundred years.
What is the frequncy of the recessive allele and what is the probability a couple are both carriers assuming random mating?
Chapter 20 Solutions
Concepts of Genetics (12th Edition)
Ch. 20 - A plasmid that is both ampicillin and tetracycline...Ch. 20 - You have just created the worlds first genomic...Ch. 20 - What undesirable or unforeseen consequences might...Ch. 20 - Do we have the ethical right to alter the genomes...Ch. 20 - Should these new technologies be regulated...Ch. 20 - HOW DO WE KNOW? In this chapter we focused on how...Ch. 20 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 20 - What roles do restriction enzymes, vectors, and...Ch. 20 - The human insulin gene contains a number of...Ch. 20 - Although many cloning applications involve...
Ch. 20 - Using DNA sequencing on a cloned DNA segment, you...Ch. 20 - Restriction sites are palindromic; that is, they...Ch. 20 - List the advantages and disadvantages of using...Ch. 20 - What are the advantages of using a restriction...Ch. 20 - In 1975, the Asilomar Conference on Recombinant...Ch. 20 - In the context of recombinant DNA technology, of...Ch. 20 - If you performed a PCR experiment starting with...Ch. 20 - Prob. 13PDQCh. 20 - Prob. 14PDQCh. 20 - You have recovered a cloned DNA segment from a...Ch. 20 - Prob. 16PDQCh. 20 - Although the capture and trading of great apes has...Ch. 20 - Prob. 18PDQCh. 20 - Prob. 19PDQCh. 20 - Prob. 20PDQCh. 20 - Traditional Sanger sequencing has largely been...Ch. 20 - How is fluorescent in situ hybridization (FISH)...Ch. 20 - What is the difference between a knockout animal...Ch. 20 - Prob. 24PDQCh. 20 - When disrupting a mouse gene by knockout, why is...Ch. 20 - Prob. 26PDQCh. 20 - Prob. 27PDQCh. 20 - As you will learn later in the text (Special...Ch. 20 - The gel presented here shows the pattern of bands...Ch. 20 - A widely used method for calculating the annealing...Ch. 20 - Most of the techniques described in this chapter...Ch. 20 - In humans, congenital heart disease is a common...Ch. 20 - The U.S. Department of Justice has established a...Ch. 20 - Prob. 34ESP
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- Suppose a geneticist is using a three-point test cross to map three linked rabbit morphology and behavioral mutations called si, sf, and H. The gene si is associated with the silky fur phenotype, and sf is associated with the short-footed phenotype. Both si and sf are recessive mutations with respect to wild type. H is a dominant mutation that confers the hyper phenotype. The geneticist first crosses true-breeding hyper rabbits to true-breeding silky fur, short-footed rabbits. Next, the geneticist backcrosses the F₁ progeny to the silky fur, short-footed parents, and obtains the results reported in the table. Phenotype hyper silky fur, short-footed short-footed silky fur, hyper silky fur short-footed, hyper silky fur, short-footed, hyper wild type Place the genes in the correct order in the chromosome. LLIIN HEL H Number 815 807 175 169 4 5 27 29 Answer Bank si sfarrow_forwardAsthma is a common medical condition that is influenced by genetics and environment. In the US, appraximately 9% of adults have asthma. A recent genome wide association study (GWAS) identifieda genetic variation that increases asthma risk by S0% when a single copy of the risk variant is present in a genome. Which value below would represent the approximate asthma risk of an individual with this genetic variation in their genome? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a 59% b 50% 14.5% 9.5% e 9%arrow_forwardThe agouti gene determines coat colour in mice. Heterozygous mice have yellow coats, while homozygous dominant mice have black coats. However, having two copies of the recessive alleles is lethal. In a population of 2 000 mice, 1 082 mice have black coats. a) Calculate the frequency of each allele. Show all your work and express your answer as a value between 0 and 1 rounded to two decimal places. b) What percentage of the mouse population is expected to be carriers of the lethal allele? Show all your work and express your answer rounded to one decimal place. c) How many mice will die during fetal development? Show all your work and round your answer to the closest whole number.arrow_forward
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