Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 11, Problem 44P
Summary Introduction
To determine:
The difficulty in pinpointing genetic diseases and human cloning due to human mosacism.
Introduction:
The genes are the sequence of
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A female child's parents are first cousins whose fathers are brothers. Each of the first cousins' fathers has a rare genetic disease
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Only the autosomes should be analyzed.
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Both affected brothers and the affected child could be homozygous for the same rare mutation that affects the
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Hypothetically, a cell has DNA that weighs 10 picograms. This cell goes through S phase and is about to undergo mitosis. How much does the DNA of this cell weight now? How much would the DNA of the two cells produced at the end of mitosis weigh? Explain your reasoning.
Any permanent change to the structure of DNA is considered a mutation. A somatic cell mutation affects only the individual organism, while a germline mutation is passed onto the next generation.
For example, excessive amount of exposure to UV rays can lead to skin cancer. Although this type of mutation occurs in the somatic cells, every individual has different susceptibility to skin cell mutations upon exposure to UV rays.
The susceptibility is located in the germ cell and is heritable. The individuals who choose to overexpose themselves to UV rays increase their likelihood of obtaining undesirable mutations in their somatic cells.
Unlike suntanning, there are other activities we engage in that can lead to germline mutations. These activities should be avoided if possible as they lead to heritable mutations and cancer.
Using 200 words or less, identify one human activity that can lead to a heritable mutation.
Explain how it affects the individual and how it can be passed onto the…
Chapter 11 Solutions
Genetics: From Genes to Genomes
Ch. 11 - Choose the phrase from the right column that best...Ch. 11 - Would you characterize the pattern of inheritance...Ch. 11 - Would you be more likely to find single nucleotide...Ch. 11 - A recent estimate of the rate of base...Ch. 11 - If you examine Fig. 11.5 closely, you will note...Ch. 11 - Approximately 50 million SNPs have thus far been...Ch. 11 - Mutations at simple sequence repeat SSR loci occur...Ch. 11 - Humans and gorillas last shared a common ancestor...Ch. 11 - In 2015, an international team of scientists...Ch. 11 - Using PCR, you want to amplify an approximately 1...
Ch. 11 - Prob. 11PCh. 11 - The previous problem raises several interesting...Ch. 11 - You want to make a recombinant DNA in which a PCR...Ch. 11 - You sequence a PCR product amplified from a...Ch. 11 - Prob. 15PCh. 11 - The trinucleotide repeat region of the Huntington...Ch. 11 - Sperm samples were taken from two men just...Ch. 11 - Prob. 18PCh. 11 - a. It is possible to perform DNA fingerprinting...Ch. 11 - On July 17, 1918, Tsar Nicholas II; his wife the...Ch. 11 - The figure that follows shows DNA fingerprint...Ch. 11 - Microarrays were used to determine the genotypes...Ch. 11 - A partial sequence of the wild-type HbA allele is...Ch. 11 - a. In Fig. 11.17b, PCR is performed to amplify...Ch. 11 - The following figure shows a partial microarray...Ch. 11 - Scientists were surprised to discover recently...Ch. 11 - The microarray shown in Problem 25 analyzes...Ch. 11 - The figure that follows shows the pedigree of a...Ch. 11 - One of the difficulties faced by human geneticists...Ch. 11 - Now consider a mating between consanguineous...Ch. 11 - The pedigree shown in Fig. 11.22 was crucial to...Ch. 11 - You have identified a SNP marker that in one large...Ch. 11 - The pedigrees indicated here were obtained with...Ch. 11 - Approximately 3 of the population carries a mutant...Ch. 11 - The drug ivacaftor has recently been developed to...Ch. 11 - In the high-throughput DNA sequencing protocol...Ch. 11 - A researcher sequences the whole exome of a...Ch. 11 - As explained in the text, the cause of many...Ch. 11 - Figure 11.26 portrayed the analysis of Miller...Ch. 11 - A research paper published in the summer of 2012...Ch. 11 - Table 11.2 and Fig. 11.27 together portray the...Ch. 11 - The human RefSeq of the entire first exon of a...Ch. 11 - Mutations in the HPRT1 gene in humans result in at...Ch. 11 - Prob. 44P
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- We are not single celled organisms and multiple cell divisions occur between fertilization and production of gametes. In males there are an estimated 400 divisions before production of gametes and in females about 30 divisions. Can you think of why this is? Is a new mutation arising from DNA replication more likely to occur because of errors in the male or the female germline?arrow_forwardAll the cells of one organism share the same genome. However, during development, some cells develop into skin cells while others develop into muscle cells. Briefly explain how the same genetic instructions can result in two different cell types in the same organism.arrow_forwardThe microscope image above shows the human chromosomes from a white blood cell. To create the image, researchers put cells in culture under conditions that encourage the cells to divide. They bathed the cells in a hypotonic (low salt) solution, which caused the cells to swell until their plasma membrane burst open. They "squashed" the chromosomes to spread them out, and stained them with a dye to make them visible under the microscope. Human chromosomes are numbered from longest (1) to shortest (22) plus the sex chromosomes X and Y. In the image chromosome 1 is about 7 micrometers. Answer the following questions. 1) What word(s) in the description above indicates that the chromosomes are not from a cell undergoing meiosis? 2) Based on the size, shape and appearance of the chromosomes in the image, in what cell cycle stage was the cell that the chromosomes came from? How can you tell? 3) Does the image suggest that centromere sequences are always located in the middle of a…arrow_forward
- All the cells of one organisms share the genome. However, during development, some cells develop into skin cells while others develop into muscle cells. How can the same genetic instructions result in two different cell types in the same organism? Thoroughly explain your answer.arrow_forwardThe continuity of life depends on a cell cycle during which genetic information is passed from a parent cell to daughter cells. Because cell division plays several important roles in life, it is important that the cycle be regulated. Which of the following are reasons the cell cycle must be regulated? Select all that apply. The continuity of life depends on a cell cycle during which genetic information is passed from a parent cell to daughter cells. Because cell division plays several important roles in life, it is important that the cycle be regulated.Which of the following are reasons the cell cycle must be regulated? Select all that apply.[ ]To make sure cells only divide when conditions are favorable for growth and development of the organism[ ]To make sure daughter cells end up with the right number of chromosomes[ ]To make sure daughter cells are genetically different from the parent cell[ ]To allow cells to respond to cues from their internal state and from their environment.arrow_forwardDNA contains the genetic information that controls all processes of heredity in a cell. The total length of all DNA in the cells of a human body can stretch to the moon and back four times.The terms that describe a length of DNA and the form in which it remains for most of its life, respectively are: Select one: a. Length of DNA Form in which it spends most of its time life Centromere Locus b. Length of DNA Form in which it spends most of its time life Chromosome Chromatin c. Length of DNA Form in which it spends most of its time life Chromosome Centromere d. Length of DNA Form in which it spends most of its time life Centromere Telomerearrow_forward
- When the human genome sequence was finally completed, scientists were surprised to discover that the genome contains far fewer genes than expected. How many genes are present in the human genome? Scientists have also found that there are many more different kinds of proteins in human cells than there are different genes in the genome. How can this be explained?arrow_forwardMost forms of cancer are caused by environmental agents that produce mutations in somatic cells. Is an individual with cancer considered a genetic mosaic? Explain why or why not.arrow_forwardYour friend sends you two cancerous cell lines to examine and determine possible mutations. The results are shown below: Cell Line Mutation WT none (wild type DNA) 1 a deletion at the same region on both copies of chromosome 4 2 a point mutation in a gene on only one copy of chromosome 7 You learn that cell line 1 is a skin cancer cell line, and the deleted region normally contains an important cell cycle control gene. You obtain another cell line (cell line 3) that has one wild-type copy, and one loss-of-function mutant copy of this gene Based on this data, which of the following is true of the cell lines? Select all that apply Cell line 3 will display a cancerous phenotype The important cell cycle control gene could be p16, whose gene product prevents progression through the cell cycle unless all checks out Cell line 3 will display a normal phenotype V The important cell cycle control gene could be cyclin d, whose gene product drives G1 to S phase transitionarrow_forward
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