Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 11, Problem 19P
| a. | It is possible to perform DNA fingerprinting with SNPs instead of SSRs as DNA markers, but in general you would need to examine more SNP markers than the 13 SSRs used in the CODIS database to be sure of a match. Explain why. |
| b. | DNA fingerprinting has been used to verify pedigrees of valuable animals such as show dogs, racing greyhounds, and thoroughbred horses. However, the technology is much harder to apply in these cases than it is in |
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Chapter 11 Solutions
Genetics: From Genes to Genomes
Ch. 11 - Choose the phrase from the right column that best...Ch. 11 - Would you characterize the pattern of inheritance...Ch. 11 - Would you be more likely to find single nucleotide...Ch. 11 - A recent estimate of the rate of base...Ch. 11 - If you examine Fig. 11.5 closely, you will note...Ch. 11 - Approximately 50 million SNPs have thus far been...Ch. 11 - Mutations at simple sequence repeat SSR loci occur...Ch. 11 - Humans and gorillas last shared a common ancestor...Ch. 11 - In 2015, an international team of scientists...Ch. 11 - Using PCR, you want to amplify an approximately 1...
Ch. 11 - Prob. 11PCh. 11 - The previous problem raises several interesting...Ch. 11 - You want to make a recombinant DNA in which a PCR...Ch. 11 - You sequence a PCR product amplified from a...Ch. 11 - Prob. 15PCh. 11 - The trinucleotide repeat region of the Huntington...Ch. 11 - Sperm samples were taken from two men just...Ch. 11 - Prob. 18PCh. 11 - a. It is possible to perform DNA fingerprinting...Ch. 11 - On July 17, 1918, Tsar Nicholas II; his wife the...Ch. 11 - The figure that follows shows DNA fingerprint...Ch. 11 - Microarrays were used to determine the genotypes...Ch. 11 - A partial sequence of the wild-type HbA allele is...Ch. 11 - a. In Fig. 11.17b, PCR is performed to amplify...Ch. 11 - The following figure shows a partial microarray...Ch. 11 - Scientists were surprised to discover recently...Ch. 11 - The microarray shown in Problem 25 analyzes...Ch. 11 - The figure that follows shows the pedigree of a...Ch. 11 - One of the difficulties faced by human geneticists...Ch. 11 - Now consider a mating between consanguineous...Ch. 11 - The pedigree shown in Fig. 11.22 was crucial to...Ch. 11 - You have identified a SNP marker that in one large...Ch. 11 - The pedigrees indicated here were obtained with...Ch. 11 - Approximately 3 of the population carries a mutant...Ch. 11 - The drug ivacaftor has recently been developed to...Ch. 11 - In the high-throughput DNA sequencing protocol...Ch. 11 - A researcher sequences the whole exome of a...Ch. 11 - As explained in the text, the cause of many...Ch. 11 - Figure 11.26 portrayed the analysis of Miller...Ch. 11 - A research paper published in the summer of 2012...Ch. 11 - Table 11.2 and Fig. 11.27 together portray the...Ch. 11 - The human RefSeq of the entire first exon of a...Ch. 11 - Mutations in the HPRT1 gene in humans result in at...Ch. 11 - Prob. 44P
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- Answer each of the following correctly. Designer Genes Work (This is all about Applications of Recombinant DNA) 1. How does DNA Replicate? 2. What is Genetically Modified Organism (GMO)? 3. Illustrate your own Designer genes based on the following: 1. Identify a special trait. 2. Identify a source organism. 3. Identify a target orgsnism 4. Identify the modified/added trait. Example: Hot Tomato > Chili > Tomato > Spicy Tomato (Look to the picture I provided for this)arrow_forwardAnswer each of the following correctly. Designer Genes Work (This is all about Applications of Recombinant DNA) 1. How does DNA Replicate? 2. What is Genetically Modified Organism (GMO)? 3. Illustrate your own Designer genes based on the following: 1. Identify a special trait. 2. Identify a source organism. 3. Identify a target orgsnism 4. Identify the modified/added trait.arrow_forwarda. DNA fingerprinting is a method of visualizing similarities and differences in the DNA sequence of individuals. Arrange the following items so that they show the DNA fingerprinting steps in proper order: - Gel electrophoresis - Stain or probe for DNA - cut DNA into fragments - Amplify DNA sample using PCR b. On the gel shown below are four DNA samples. Samples A to C are taken from tissues of landslide victims that are being identified, while sample D came from a hair sample brought by a mother looking for the remains of her son. (see img) i. If similar band patterns in a gel are created using the same restriction enzyme, what does that tell you about the DNA sequence of the samples? ii. In sample C, only two fragments were created. How many restriction sites (regions where enzymes cut) are present in sample C?arrow_forward
- 4) The government of Iceland has built a database which contains genetic informaiton about individuals using SNP analysis and other methods, which can be used to help diagnose pre-disposition to genetic diseases and other conditions. What are some ethical issues that are raised by compiling such a database?arrow_forwardIt has been suggested that it would make the study of human diseases easier if cloned transgenic animals were produced that carried faulty versions of human genes (e.g., the gene that causes cystic fibrosis). a. Why would such animals be useful in medical research? : b. What ethical questions are raised by the creation of such transgenic animals?arrow_forwardPedigree Analysis Is a Basic Method in Human Genetic: What does OMIM stand for? What kinds of information are in this database?arrow_forward
- Pedigree Analysis Is a Basic Method in Human Genetic: What are the reasons that pedigree charts are used?arrow_forwardAssume that you are working as an expert of karyotype analysis in a Genetics Laboratory. You are using G-Banding for staining to chromosomes. Explain briefly the steps of karyotype analysis from blood samples.arrow_forwardA. What are some reasons a person might want to clone a human? B. What animal was cloned in 1885?arrow_forward
- Describe the main technique for amplifying a segment of DNA (like the one you suspect is involved in Lee’s cancer) from a complex mixture of genomic DNA. Remember that the entire human genome sequence is known. (Hint: This is a technique that is commonly used by laboratories that do genetic testing and various other applications of molecular biology.)arrow_forwardBriefly describe the applications of SNPs in DNA typing.arrow_forwardThe figure below represents the size of various SSRS that are used for forensic analysis. The bars corresponding to each locus represent the range of size of the various alleles of the locus. 100 bp 200 bp 300 bp D8S1179 D21S11 D7S820 CSF1PO D3S1358 TH01 D13S317 D16S539 D2S1338 D199433 VWA TPOX D18S51 FGA D5S818 III Each color in the figure represents a set of molecular markers that can be analyzed simultaneously. Which of the following pairs of markers, which are not grouped together in the figure, could be analyzed simultaneously if they were the only two markers being studied? FGA and CSF1PO 400 bp THO and VWA THO and TPOX O TOPX and FGAarrow_forward
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