Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 11, Problem 20P
On July 17, 1918, Tsar Nicholas II; his wife the Tsarina Alix; their daughters Olga, Tatiana, Maria, and Anastasia; their son, the Tsarevitch (Crown Prince) Alexei; and four loyal retainers were murdered by Bolshevik revolutionaries. The bodies were not recovered for many years, fueling legends that Grand Duchess Anastasia had escaped, and allowing a woman named Anna Anderson to claim that she was Anastasia. In 1991 and in 2007, two mass graves with a total of nine skeletal remains were unearthed at Ekaterinburg in Russia’s Ural Mountains. The table that follows presents partial DNA fingerprint analysis (using only five SSR loci and the sex chromosome marker Amel) of these skeletons. Entries separated by commas indicate alleles (number of repeating units).
| a. | What is the most likely identification for each skeleton? (Note: You cannot differentiate among any of the daughters based on this information alone.) |
| b. | Three PCR reactions failed to yield PCR products. If the reactions had worked properly, what alleles would you expect to see in each case? |
| c. | Are any of the daughters identical twins? |
| d. | What kind of evidence could you obtain from the skeletons to differentiate among the daughters? |
| e. | How do these DNA fingerprints repudiate the claims of Anna Anderson? The DNA fingerprint data in the table are certainly consistent with the idea that some of these skeletons were members of the Tsar’s family, but they do not prove the hypothesis. To investigate further,  |
| f. | For autosomal DNA markers, what percentage of alleles in the Tsarina’s skeleton should match with alleles in Prince Philip’s genome? |
| g. | For autosomal DNA markers, what percentage o f alleles in the Tsarevitch’s skeleton should match with alleles in Prince Philip’s genome? |
| h. | A question for genealogy aficionados: What is Prince Philip’s relationship with the Tsarina? |
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Chapter 11 Solutions
Genetics: From Genes to Genomes
Ch. 11 - Choose the phrase from the right column that best...Ch. 11 - Would you characterize the pattern of inheritance...Ch. 11 - Would you be more likely to find single nucleotide...Ch. 11 - A recent estimate of the rate of base...Ch. 11 - If you examine Fig. 11.5 closely, you will note...Ch. 11 - Approximately 50 million SNPs have thus far been...Ch. 11 - Mutations at simple sequence repeat SSR loci occur...Ch. 11 - Humans and gorillas last shared a common ancestor...Ch. 11 - In 2015, an international team of scientists...Ch. 11 - Using PCR, you want to amplify an approximately 1...
Ch. 11 - Prob. 11PCh. 11 - The previous problem raises several interesting...Ch. 11 - You want to make a recombinant DNA in which a PCR...Ch. 11 - You sequence a PCR product amplified from a...Ch. 11 - Prob. 15PCh. 11 - The trinucleotide repeat region of the Huntington...Ch. 11 - Sperm samples were taken from two men just...Ch. 11 - Prob. 18PCh. 11 - a. It is possible to perform DNA fingerprinting...Ch. 11 - On July 17, 1918, Tsar Nicholas II; his wife the...Ch. 11 - The figure that follows shows DNA fingerprint...Ch. 11 - Microarrays were used to determine the genotypes...Ch. 11 - A partial sequence of the wild-type HbA allele is...Ch. 11 - a. In Fig. 11.17b, PCR is performed to amplify...Ch. 11 - The following figure shows a partial microarray...Ch. 11 - Scientists were surprised to discover recently...Ch. 11 - The microarray shown in Problem 25 analyzes...Ch. 11 - The figure that follows shows the pedigree of a...Ch. 11 - One of the difficulties faced by human geneticists...Ch. 11 - Now consider a mating between consanguineous...Ch. 11 - The pedigree shown in Fig. 11.22 was crucial to...Ch. 11 - You have identified a SNP marker that in one large...Ch. 11 - The pedigrees indicated here were obtained with...Ch. 11 - Approximately 3 of the population carries a mutant...Ch. 11 - The drug ivacaftor has recently been developed to...Ch. 11 - In the high-throughput DNA sequencing protocol...Ch. 11 - A researcher sequences the whole exome of a...Ch. 11 - As explained in the text, the cause of many...Ch. 11 - Figure 11.26 portrayed the analysis of Miller...Ch. 11 - A research paper published in the summer of 2012...Ch. 11 - Table 11.2 and Fig. 11.27 together portray the...Ch. 11 - The human RefSeq of the entire first exon of a...Ch. 11 - Mutations in the HPRT1 gene in humans result in at...Ch. 11 - Prob. 44P
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