Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 4, Problem 26P
Interpretation Introduction

(a)

Interpretation:

The number of different 8-mer sequences of DNA needs to be determined, where there are 16 possible dinucleotides and 64 possible trinucleotides and each position can be one of the four bases, corresponding to two bits of information.

Introduction:

Deoxyribonucleic acid (DNA) is a molecule consisting of two strands that twist around each other to create a double strand containing DNA directions for the development, working, growth and breeding of all recognized species and many bacteria. Also recognized as polynucleotides, the two DNA sections consist of simpler monomeric blocks called nucleotides.

Interpretation Introduction

(b)

Interpretation:

The number of bits of information that are stored in an 8-mer DNA sequence, in E.coli genome and in human genome needs to be determined.

Introduction:

Deoxyribonucleic acid (DNA) is a molecule consisting of two strands that twist around each other to create a double strand containing DNA directions for the development, working, growth and breeding of all recognized species and many bacteria. Also recognized as polynucleotides, the two DNA sections consist of simpler monomeric blocks called nucleotides.

Interpretation Introduction

(c)

Interpretation:

The calculated values in part (b) needs to be compared with the information stored on a 2 gigabyte flash drive.

Introduction:

Deoxyribonucleic acid (DNA) is a molecule consisting of two strands that twist around each other to create a double strand containing DNA directions for the development, working, growth and breeding of all recognized species and many bacteria. Also recognized as polynucleotides, the two DNA sections consist of simpler monomeric blocks called nucleotides.

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. Some naturally occurring polynucleotide sequences are palindromic; that is, they are self-complementary about an axis of symmetry. Such a sequence is TCAAGTCCATGGACTTGG AGTTCAGGTACCTGAACC Show how this structure might form a double hairpin, or cruciform, conformation. Indicate the center of symmetry in the sequence and the bounds of the cruciform.
DNA Structure A. Draw an A-T base pair with the appropriate number of hydrogen bonds. You don’t have to include all the details such as every side-group but do depict the 3’ OH groups. B. What is meant by anti-parallel when referring to a DNA molecule? C. What are the major and minor grooves in the DNA structure and what significance do they have?
Name a.) ( pair. Indicate hydrogen bonds with dashed lines, number the atoms in the bases according to IUPAC convention, and circle the pyrimidine. Additionally, indicate where the sugar is attached to the base, the major groove, and the minor groove. 8.) Looking at the bases from above, draw a Watson-Crick C-G base b.) ( triple helix (shown below). In this triple helix, a third strand binds in the major groove via base pairs with the existing Watson-Crick bases. This additional base pair is called a Hoogsteen base pair and is indicated by an asterisk followed by the third base. On your drawing add a cytosine in the appropriate location to indicate a CG*C base pair. , it is possible for nucleic acids to form a structure known as a c.) ( between turns, glycosidic bond conformation and sugar conformation differs between A-form DNA and Z-form DNA, Which one is PNA? Indicate (possibly using a table) how the strand width, distance
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