Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 4, Problem 9P
Interpretation Introduction
Interpretation:
The minimum length of a DNA sequence that will appear only once in the human genome needs to be determined, if the human genome contains 3 billion nucleotides arranged in a vast array of the sequence. This is to be taken into account that only one strand and all four nucleotides have the same probability of appearance.
Concept introduction:
Deoxyribonucleic acid (DNA) is a molecule consisting of two strands that twist around each other to create a double strand DNA containing directions for the development, working, growth and breeding of all recognized species and many bacteria. It is also recognized as polynucleotides. The two DNA sections consist of simpler monomeric blocks called nucleotides.
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For some DNAS it is possible to separate the two strands, after denaturation,
in a CsCl gradient.
(a) What property of any DNA determines where it will band in a CsCI
gradient?
(b) What kind of DNA might have two strands that differ sufficiently in this
property that they could be separated after denaturation?
For some DNAs, it is possible to separate the two strands, after denaturation,in a CsCl gradient.(a) What property of any DNA determines where it will band in a CsClgradient?(b) What kind of DNA might have two strands that differ sufficiently in thisproperty that they could be separated after denaturation?
. In a supercoiled DNA, a stretch of about 20 base pairs changes
from the B form to the Z form. What is the change in (a) T, (b) L,
and (c) W?
Chapter 4 Solutions
Biochemistry
Ch. 4 - Prob. 1PCh. 4 - Prob. 2PCh. 4 - Prob. 3PCh. 4 - Prob. 4PCh. 4 - Prob. 5PCh. 4 - Prob. 6PCh. 4 - Prob. 7PCh. 4 - Prob. 8PCh. 4 - Prob. 9PCh. 4 - Prob. 10P
Ch. 4 - Prob. 11PCh. 4 - Prob. 12PCh. 4 - Prob. 13PCh. 4 - Prob. 14PCh. 4 - Prob. 15PCh. 4 - Prob. 16PCh. 4 - Prob. 17PCh. 4 - Prob. 18PCh. 4 - Prob. 19PCh. 4 - Prob. 20PCh. 4 - Prob. 21PCh. 4 - Prob. 22PCh. 4 - Prob. 23PCh. 4 - Prob. 24PCh. 4 - Prob. 25PCh. 4 - Prob. 26PCh. 4 - Prob. 27PCh. 4 - Prob. 28PCh. 4 - Prob. 29PCh. 4 - Prob. 30PCh. 4 - Prob. 31PCh. 4 - Prob. 32PCh. 4 - Prob. 33PCh. 4 - Prob. 34PCh. 4 - Prob. 35PCh. 4 - Prob. 36PCh. 4 - Prob. 37PCh. 4 - Prob. 38PCh. 4 - Prob. 39PCh. 4 - Prob. 40PCh. 4 - Prob. 41PCh. 4 - Prob. 42PCh. 4 - Prob. 43PCh. 4 - Prob. 44PCh. 4 - Prob. 45PCh. 4 - Prob. 46PCh. 4 - Prob. 47PCh. 4 - Prob. 48PCh. 4 - Prob. 49PCh. 4 - Prob. 50PCh. 4 - Prob. 51PCh. 4 - Prob. 52P
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- DNA Stability/Chapter 4 A solution of DNA contains two different DNA molecules. Molecule 1 is 500 base pairs and contains 100 A’s. Molecule 2 is 500 base pairs and contains 300 A’s. (1) How many AT base pairs and GC base pairs is in each DNA molecule? (2) How many, G’s, A’s, T’s and C’s are in each molecule? (3) Draw one figure that shows the relative melting temperature of the two DNA molecules.arrow_forwardWhen Chargaffwas performing his experiments, the tetranucleotide hypothesis, which stated that DNA was composed of GACT nucleotide repeats, was the most widely accepted view of DNA’s composition. How did Chargaff disprove this hypothesis?arrow_forwardBelow is a sequence of 540 bases from a genome. What information would you use to find the beginnings and ends of open reading frames? How many open reading frames can you find in this sequence? Which open reading frame is likely to represent a protein- coding sequence, and why? Which are probably not functioning protein-coding sequences, and why? Note: for simplicitys sake, analyze only this one strand of the DNA double helix, reading from left to right, so you will only be analyzing three of the six reading frames shown in Figure 19.4.arrow_forward
- Human Genome Replication Rate Assume DNA replication proceeds at a rate of 100 base pairs per second in human cells and origins of replication occur every 300 kbp. Assume also that human DNA polymerases are highly processive and only two molecules of DNA polymerase arc needed per replication fork. How long would it take to replicate the entire diploid human genome? How many molecules of DNA polymerase does each cell need to carry out this task?arrow_forwardDNA contains many hydrogen bonds. Are hydrogen bonds stronger or weaker than covalent bonds? What are the consequences of this difference in strength?arrow_forward. While studying the structure of a small gene that was recently sequenced during the Human Genome Project, an investigator notices that one strand of the DNA molecule contains the following: 20 adenine (A) bases 30 cytosine (C) bases25 guanine (G) bases 22 thymine (T) bases How many of each base is found in the complete double-stranded molecule?arrow_forward
- DNA Structure A. Draw an A-T base pair with the appropriate number of hydrogen bonds. You don’t have to include all the details such as every side-group but do depict the 3’ OH groups. B. What is meant by anti-parallel when referring to a DNA molecule? C. What are the major and minor grooves in the DNA structure and what significance do they have?arrow_forwardZ-DNA derives its name from the zig-zag conformation of phosphate groups. What features of the DNA molecule allow this structure to form?arrow_forwardBuild a 3D model of a DNA molecule:-3-dimensional built structure -Contain sugar-phosphate backbones (constructed as separate molecules) -Contain nitrogenous bases (paired clearly and correctly) -Have a minimum of 10 base-pairs (minimum of 10 “rungs” or “steps” on the ladder) with the correct number of hydrogen bonds illustrated between each of the base pairs. -Have the orientation labeled on each strand and make sure the two strands are antiparallel.arrow_forward
- STRUCTURE OF DNA Ueing the complementary base pairing rules in DNA, complete the following base pairs: Adenine - Cytosine -i Guanine -i Thymine - : Adenine : Cytosine :: Guanine :: Thymine 1arrow_forward. A viral DNA is analyzed and found to have the following base com- position, in mole percent: A = 32, G = 16, T = 40, C = 12. (a) What can you conclude about the structure of this DNA? (b) What kind of secondary structure do you think it would have?arrow_forward18 Fred Sanger developed an efective DNA sequencing technique in 1977. The peed at which DNA.can be sequenced has been increasing rapidly since the introduction of DNA sequencing The length of DNA that can be sequenced in a given time is measured in base pairs or kilobase pairs. In 1980, the speed at which DNA could be sequenced by a single machine was approximately 500 base palrs per hour. In 2016 that speed had increased to approximately 50 million kilobase pairs per hour. Calculate how many times faster the speed of DNA sequencing is in 2016 compared with 1980.arrow_forward
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