Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 20, Problem 2P
Characterize the differences between tumor cells and normal cells in terms of the following properties. In cancer cells, how might each of these properties contribute to tumor progression?
| a. | contact inhibition |
| b. | autocrine stimulation |
| c. | apoptosis |
| d. | telomerase expression |
| e. | senescence due to telomere shortening |
| f. | genomic stability |
| g. | angiogenesis |
| h. | metastasis |
| i. | susceptibility to immune surveillance |
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Which of the following factors contributes to angiogenesis as a result of a tumor growth? Select all that apply:
a. Increasing tumor's access to oxygen and nutrients
b. Increasing tumor's ability for growth, invasion, and metastasis
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d. Increasing expression of tumor-suppressor genes for cancer cells
Which of the following statements are correct about tumors and metastasis (select all that apply)?
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The majority of cancer deaths are due to primary tumor
B.
Loss of basement membrane by tumor mass is strong predictor of metastasis potential
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The tissue stroma contributes to whether a tumor cell will metastasize
D.
The majority of life threatening tumors occur in epithelial tissues
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Chapter 20 Solutions
Genetics: From Genes to Genomes
Ch. 20 - For each of the terms in the left column, choose...Ch. 20 - Characterize the differences between tumor cells...Ch. 20 - Prob. 3PCh. 20 - Prob. 4PCh. 20 - A carcinogenic compound is placed on the skin of...Ch. 20 - You have decided to study genetic factors...Ch. 20 - B cells are specialized blood cells that secrete...Ch. 20 - Molecules outside and inside the cell regulate the...Ch. 20 - Put the following steps in the correct ordered...Ch. 20 - a. Would you expect a cell to continue or to stop...
Ch. 20 - Two different protein complexes called SCF and APC...Ch. 20 - One of the hallmarks of mitotic anaphase is the...Ch. 20 - Concerning the Tools of Genetics Box Analysis of...Ch. 20 - Are genome and karyotype instabilities...Ch. 20 - Prob. 15PCh. 20 - Why dont all loss-of-function mutations that are...Ch. 20 - Chromothripsis is a rare phenomenon, first...Ch. 20 - The chromosome 9/22 translocation associated with...Ch. 20 - A female patient 19 years old, whose symptoms are...Ch. 20 - Prob. 20PCh. 20 - A generic signaling cascade is shown in the...Ch. 20 - Neurofibromatosis type 1 NF1; also known as von...Ch. 20 - Families with germ-line BRCA1 or BRCA2...Ch. 20 - The text explained that retroviruses can cause...Ch. 20 - Hepatocellular carcinoma is the most frequent form...Ch. 20 - Suppose that instead of microarrays, you analyzed...Ch. 20 - Prob. 27PCh. 20 - Glioblastoma multiforme GBM is the most common and...Ch. 20 - a. The legend to Fig. 20.29 identifies which of...Ch. 20 - The website CBioPortal http://www.cbioportal.org...
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