Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 20, Problem 17P
Chromothripsis is a rare phenomenon, first discovered in cancer cells, where a single chromosome “shatters” into many fragments and is reassembled in a rearranged form by the DNA repair machinery. (The underlying mechanism causing the shattering is not understood.) Approximately 2% of cancers contain cells with a shattered chromosome. Explain how chromothripsis could contribute to cancer.
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Chapter 20 Solutions
Genetics: From Genes to Genomes
Ch. 20 - For each of the terms in the left column, choose...Ch. 20 - Characterize the differences between tumor cells...Ch. 20 - Prob. 3PCh. 20 - Prob. 4PCh. 20 - A carcinogenic compound is placed on the skin of...Ch. 20 - You have decided to study genetic factors...Ch. 20 - B cells are specialized blood cells that secrete...Ch. 20 - Molecules outside and inside the cell regulate the...Ch. 20 - Put the following steps in the correct ordered...Ch. 20 - a. Would you expect a cell to continue or to stop...
Ch. 20 - Two different protein complexes called SCF and APC...Ch. 20 - One of the hallmarks of mitotic anaphase is the...Ch. 20 - Concerning the Tools of Genetics Box Analysis of...Ch. 20 - Are genome and karyotype instabilities...Ch. 20 - Prob. 15PCh. 20 - Why dont all loss-of-function mutations that are...Ch. 20 - Chromothripsis is a rare phenomenon, first...Ch. 20 - The chromosome 9/22 translocation associated with...Ch. 20 - A female patient 19 years old, whose symptoms are...Ch. 20 - Prob. 20PCh. 20 - A generic signaling cascade is shown in the...Ch. 20 - Neurofibromatosis type 1 NF1; also known as von...Ch. 20 - Families with germ-line BRCA1 or BRCA2...Ch. 20 - The text explained that retroviruses can cause...Ch. 20 - Hepatocellular carcinoma is the most frequent form...Ch. 20 - Suppose that instead of microarrays, you analyzed...Ch. 20 - Prob. 27PCh. 20 - Glioblastoma multiforme GBM is the most common and...Ch. 20 - a. The legend to Fig. 20.29 identifies which of...Ch. 20 - The website CBioPortal http://www.cbioportal.org...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- A person with cancer walks into the classroom. As a biology class, we ask if we can examine some of the cancerous cells and find that many of these cancerous cells have an extra chromosome 10 (trisomy) leading to more cyclin for forming the MPF being made, leading to uncontrollable cell division (i.e. tumor and progression to cancer). What would cause extra chromosomes in cells (be it somatic or gametic cells)? Select one: a. None of these choices are linked to how sister chromatids separate and would lead to extra chromosomes in daughter cells of cell division. b. APC not functioning correctly to add ubiquitin to the cohesins, thus sister chromatids do not split correctly during cell division c. MPF itself would cause more chromosome replication d. APC is overly functioning adding cohesins to the sister chromatidsarrow_forward"A deletion of a portion of a chromosome need not be very great before the effects become severe". Explain this ?arrow_forward(b): How many forms can naturally occurring DNA exist in? Explain how these forms are characterized. What properties of the functional groups determine the binding of DNA with anti-cancer agents? Explain.arrow_forward
- Describe the role of mismatch repair (MMR) in DNA repair.Why do mutations in MMR proteins increase the risk ofhuman cancer?arrow_forwardWhat common mutation occurs in many human cancers? Explain how it can have this effect.arrow_forwardDefine the following terms: a. chromosome b. chromatinarrow_forward
- A subset of colorectal cancers is associated with mutations in the Mut genes which code for proteins involved in repairing DNA mismatches. How would mutations in the Mut genes affect the DNA of an individual?arrow_forwardCertain organisms contain cells that possess polytene chromosomes. What are polytene chromosomes, where are they found, and what function do they serve?arrow_forwardWhat difference exists between the compaction of chromosomes during metaphase versus interphase? Give at least one reason why this difference may be necessary.arrow_forward
- Describe the role of mismatch repair (MMR) in DNA repair. Why can mutations in MMR increase the risk of human cancer?arrow_forward3) Examine the graph showing the relative percentage normal and cancer cells spend in various stages of the cell cycle. Based on the information in the graphs, infer how cancer cells differ from typical, noncancerous cells. Select ALL that apply. A) Cancer cells do not replicate their DNA. B) Cancer cells replicate their DNA too quickly. C) Cancer cells do not go through interphase during their cell cycle. D) Cancer cells spend more time dividing compared to typical cells. E) Cancer cells do not always grow to the same size as typical cells. more than 1 answer. not gradedarrow_forwardThe microscope image above shows the human chromosomes from a white blood cell. To create the image, researchers put cells in culture under conditions that encourage the cells to divide. They bathed the cells in a hypotonic (low salt) solution, which caused the cells to swell until their plasma membrane burst open. They "squashed" the chromosomes to spread them out, and stained them with a dye to make them visible under the microscope. Human chromosomes are numbered from longest (1) to shortest (22) plus the sex chromosomes X and Y. In the image chromosome 1 is about 7 micrometers. Answer the following questions. 1) What word(s) in the description above indicates that the chromosomes are not from a cell undergoing meiosis? 2) Based on the size, shape and appearance of the chromosomes in the image, in what cell cycle stage was the cell that the chromosomes came from? How can you tell? 3) Does the image suggest that centromere sequences are always located in the middle of a…arrow_forward
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