Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 20, Problem 10P
| a. | Would you expect a cell to continue or to stop dividing at a nonpermissive high temperature if it is a temperature-sensitive Ras mutant whose protein product is fixed in the GTP-bound form at nonpermissive temperature? |
| b. | What would you expect if you had a temperature-sensitive mutant in which the Ras protein stays in the GDP-bound form at high temperature? |
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The following diagram is from a paper investigating the role of β4 integrin in breast cancer. They examined the expression of miRNAs (rows) in ten β4 positive and ten β4 negative breast cancers. Each array was performed in triplicate (columns) (Gerson, 2012).
A. Describe how you think this array was carried out.
B. β4 integrin is normally involved in attaching epithelial cells to the extracellular matrix and holding them in place, but in cancer, it can be involved in attaching cells to actin and increasing motility as well as in cell signaling. How is β-integrin expression related to miRNA expression? What do you think this means for these breast cancers?
When Ras is activated, cells will divide. A dominant-negative form of Ras clings too tightly
to GDP. You introduce a dominant-negative form of Ras into cells that also have a normal
version of Ras. Which of the following statements is TRUE?
O a. The normal Ras in the cells you create will not be able to bind GDP because the
ion
dominant-negative Ras binds to GDP too tightly.
O b. The cells you create will divide more frequently compared to normal cells in
response to the extracellular signals that typically activate Ras.
c. The cells you create will divide less frequently than normal cells in response to the
extracellular signals that typically activate Ras.
O d. The cells you create will run out of the GTP necessary to activate Ras.
Clear my choice
The following diagram is from a paper investigating the role of β4 integrin in breast cancer. They examined the expression of miRNAs (rows) in ten β4 positive and ten β4 negative breast cancers. Each array was performed in triplicate (columns) (Gerson, 2012).
B. β4 integrin is normally involved in attaching epithelial cells to the extracellular matrix and holding them in place, but in cancer, it can be involved in attaching cells to actin and increasing motility as well as in cell signaling. How is β-integrin expression related to miRNA expression? What do you think this means for these breast cancers?
Chapter 20 Solutions
Genetics: From Genes to Genomes
Ch. 20 - For each of the terms in the left column, choose...Ch. 20 - Characterize the differences between tumor cells...Ch. 20 - Prob. 3PCh. 20 - Prob. 4PCh. 20 - A carcinogenic compound is placed on the skin of...Ch. 20 - You have decided to study genetic factors...Ch. 20 - B cells are specialized blood cells that secrete...Ch. 20 - Molecules outside and inside the cell regulate the...Ch. 20 - Put the following steps in the correct ordered...Ch. 20 - a. Would you expect a cell to continue or to stop...
Ch. 20 - Two different protein complexes called SCF and APC...Ch. 20 - One of the hallmarks of mitotic anaphase is the...Ch. 20 - Concerning the Tools of Genetics Box Analysis of...Ch. 20 - Are genome and karyotype instabilities...Ch. 20 - Prob. 15PCh. 20 - Why dont all loss-of-function mutations that are...Ch. 20 - Chromothripsis is a rare phenomenon, first...Ch. 20 - The chromosome 9/22 translocation associated with...Ch. 20 - A female patient 19 years old, whose symptoms are...Ch. 20 - Prob. 20PCh. 20 - A generic signaling cascade is shown in the...Ch. 20 - Neurofibromatosis type 1 NF1; also known as von...Ch. 20 - Families with germ-line BRCA1 or BRCA2...Ch. 20 - The text explained that retroviruses can cause...Ch. 20 - Hepatocellular carcinoma is the most frequent form...Ch. 20 - Suppose that instead of microarrays, you analyzed...Ch. 20 - Prob. 27PCh. 20 - Glioblastoma multiforme GBM is the most common and...Ch. 20 - a. The legend to Fig. 20.29 identifies which of...Ch. 20 - The website CBioPortal http://www.cbioportal.org...
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