Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 20, Problem 18P
The chromosome 9/22 translocation associated with CML (chronic myelogenous leukemia) is called the Philadelphia chromosome after the city in which its cancer association was first discovered in 1960. People with CML do not inherit this translocation—it occurs in somatic cells. Why do you think that this particular translocation that fuses the bcr and abl genes happens independently in the somatic cells of many different people?
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With age, somatic cells are thought to accumulate genomic "scars"as a
result of the inaccurate repair of double-strand breaks by non
homologous end-joining (NHEJ). Estimates based on the frequency of
breaks in primary human fibroblasts suggest that by age 70 each human
somatic cell may carry some 2000 NHEJ-induced mutations due to
inaccurate repair. If these mutations were distributed randomly around
the genome, how many genes would you expect to be affected? Would
you expect cell function to be compromised? Why or why not? (Assume
that 2% of the genome - 1.5% coding and 0.5% regulatory - is crucial
information.)
Why would a mutation in a somatic cell of a multicellular organism not necessarily result in a detectable phenotype?
Why does this translocation cause leukemia rather than cancer in a different tissue type, such as the lung?
Chapter 20 Solutions
Genetics: From Genes to Genomes
Ch. 20 - For each of the terms in the left column, choose...Ch. 20 - Characterize the differences between tumor cells...Ch. 20 - Prob. 3PCh. 20 - Prob. 4PCh. 20 - A carcinogenic compound is placed on the skin of...Ch. 20 - You have decided to study genetic factors...Ch. 20 - B cells are specialized blood cells that secrete...Ch. 20 - Molecules outside and inside the cell regulate the...Ch. 20 - Put the following steps in the correct ordered...Ch. 20 - a. Would you expect a cell to continue or to stop...
Ch. 20 - Two different protein complexes called SCF and APC...Ch. 20 - One of the hallmarks of mitotic anaphase is the...Ch. 20 - Concerning the Tools of Genetics Box Analysis of...Ch. 20 - Are genome and karyotype instabilities...Ch. 20 - Prob. 15PCh. 20 - Why dont all loss-of-function mutations that are...Ch. 20 - Chromothripsis is a rare phenomenon, first...Ch. 20 - The chromosome 9/22 translocation associated with...Ch. 20 - A female patient 19 years old, whose symptoms are...Ch. 20 - Prob. 20PCh. 20 - A generic signaling cascade is shown in the...Ch. 20 - Neurofibromatosis type 1 NF1; also known as von...Ch. 20 - Families with germ-line BRCA1 or BRCA2...Ch. 20 - The text explained that retroviruses can cause...Ch. 20 - Hepatocellular carcinoma is the most frequent form...Ch. 20 - Suppose that instead of microarrays, you analyzed...Ch. 20 - Prob. 27PCh. 20 - Glioblastoma multiforme GBM is the most common and...Ch. 20 - a. The legend to Fig. 20.29 identifies which of...Ch. 20 - The website CBioPortal http://www.cbioportal.org...
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