Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 19.5, Problem 4COMQ
Summary Introduction
Introduction:
DSBs (double-stranded breaks) are the most dangerous form of DNA (deoxyribonucleic acid) damage, since they can result in DNA loss. A cell could end up losing an important gene, which could compromise the survival of the cell. There are DNA repair systems in place to take care of this, but there is still some amount of DNA that is lost.
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Check out a sample textbook solutionStudents have asked these similar questions
Which of the following is NOT common to all repair mechanisms?
A. Detection of the lesion
B. Removal of the damaged DNA sequence/ nucleotide/ base
C. Removal of free radicals at the site of injury
D. Repair of the lesion
E. Involvement of enzymes in removing the lesion and/or repair of the
damaged sequence/nucleotide/base.
Write the order of the following components for the process of Homologous Recombination repair:
A. DNA synthesis
B. Strand invasion
C. Double-strand break
D. nucleases create uneven strands
E. DNA ligation
A.) Damaged DNA can be reversed if nucleotides can be replaced with a proper nucleotide for a correct amino acid base.
B.) Direct reversal of DNA repair can destroy the abnormal bonds of the nucleotides in the DNA sequence.
a. Statement A is correct
b. Statement B is correct
c. Both A and B are correct
d. Both A and B are incorrect
Chapter 19 Solutions
Genetics: Analysis and Principles
Ch. 19.1 - 1. A mutation changes a codon that specifies...Ch. 19.1 - A down promoter mutation causes the promoter of a...Ch. 19.1 - 3. A mutation in one gene that reverses the...Ch. 19.1 - Which of the following is an example of a somatic...Ch. 19.2 - Prob. 1COMQCh. 19.3 - Which of the following is not an example of a...Ch. 19.3 - A point mutation could be caused by a....Ch. 19.3 - One way that TNRE may occur involves the formation...Ch. 19.4 - Nitrous acid replaces amino groups with keto...Ch. 19.4 - Prob. 2COMQ
Ch. 19.4 - Prob. 3COMQCh. 19.5 - The function of photolyase is to repair a....Ch. 19.5 - Which of the following DNA repair systems may...Ch. 19.5 - 3. In nucleotide excision repair in E. coli, the...Ch. 19.5 - Prob. 4COMQCh. 19.5 - An advantage of translesion-replicating...Ch. 19 - Is each of the following mutations a transition,...Ch. 19 - Prob. 2CONQCh. 19 - What does a suppressor mutation suppress? What is...Ch. 19 - Prob. 4CONQCh. 19 - X-rays strike a chromosome in a living cell and...Ch. 19 - Prob. 6CONQCh. 19 - Prob. 7CONQCh. 19 - 8. A point mutation occurs in the middle of the...Ch. 19 - Prob. 9CONQCh. 19 - Prob. 10CONQCh. 19 - 11. Is a random mutation more likely to be...Ch. 19 - 12. Which of the following mutations could be...Ch. 19 - Prob. 13CONQCh. 19 - Discuss the consequences of a germ-line versus a...Ch. 19 - Prob. 15CONQCh. 19 - Explain how a mutagen can interfere with DNA...Ch. 19 - What type of mutation (transition, transversion,...Ch. 19 - Explain what happens to the sequence of DNA during...Ch. 19 - Distinguish between spontaneous and induced...Ch. 19 - Prob. 20CONQCh. 19 - Prob. 21CONQCh. 19 - Prob. 22CONQCh. 19 - Trinucleotide repeat expansions (TNREs) are...Ch. 19 - 24. With regard to TNRE, what is meant by the term...Ch. 19 - 25. What is the difference between the mutation...Ch. 19 - Achondroplasia is a rare form of dwarfism. It is...Ch. 19 - Prob. 27CONQCh. 19 - In the treatment of cancer, the basis for many...Ch. 19 - Prob. 29CONQCh. 19 - 30. Which of the following examples is likely to...Ch. 19 - Prob. 31CONQCh. 19 - Prob. 32CONQCh. 19 - Prob. 33CONQCh. 19 - With regard to the repair of double-strand breaks,...Ch. 19 - Prob. 35CONQCh. 19 - Prob. 36CONQCh. 19 - 37. Three common ways to repair changes in DNA...Ch. 19 - Prob. 38CONQCh. 19 - Prob. 39CONQCh. 19 - Explain how the technique of replica plating...Ch. 19 - 2. Outline how you would use the technique of...Ch. 19 - 3. From an experimental point of view, is it...Ch. 19 - Prob. 4EQCh. 19 - Prob. 5EQCh. 19 - 6. Richard Boyce and Paul Howard-Flanders...Ch. 19 - In E. coli, a variety of mutator strains have been...Ch. 19 - 2. Discuss the times in a person’s life when it is...Ch. 19 - A large amount of research is aimed at studying...
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- Which of the following types of DNA damage would be hardest to repair using the DNA repair pathways?A. Complete removal of three nucleotides in the middle of one strand.B. A covalent bond between a base on one strand and a base on the complementary strand.C. Incorporation of a sugar other than deoxyribose into one strand.D. Covalent attachment of a short polypeptide to a single base.E. A covalent bond between a base and a deoxyribose on the same strand. Please explain why it's Barrow_forwardWhen E. coli cells are mixed with recombinant vector DNA and subject to a stress such as heat shock, a small fraction of the cells will take up the plasmid DNA, a process known as : A. Ligation. B. Transformation. C. Transfection. D. Digestion.arrow_forwardA.) Homologous recombination repair are prone to error and can cause loss of genome integrity. B.) Reversal and repairing of DNA strands damage is important in maintaining genome integrity. a. Statement A is correct b. Statement B is correct c. Both A and B are correct d. Both A and B are incorrectarrow_forward
- Match the following type of DNA repair mechanism with the most appropriate definition. Nucleotide excision repair Homologous recombination Base excision repair Nonhomologous end joining A. Repairs thymine dimers by removing a section of the strand B. Corrects damaged bases by removing only the base C. Repairs double strand breaks by joining the ends D. Repairs double strand breaks by copying second chromosomearrow_forwardDouble-stranded breaks are repaired by: a). direct reversal of DNA damage b). recombinational repair c). translesion repairarrow_forwardDefine the following terms: a. transposition b. DNA glycosylase c. apurinic site d. apyrimidinic site e. mismatch repairarrow_forward
- How would nucleotide excision repair be affected if one of the followingproteins was missing? Describe the condition of the DNAif the repair was attempted in the absence of the protein.A. UvrAB. UvrCC. UvrDD. DNA polymerasearrow_forwardWhich of the following DNA repair pathways repair DNA double strand breakage that only occur in diving cells?. Please select all correct answers. A. Nucleotide excision repair (NER) B. Mismatch repair (MMR) C. Double- strand break repair(DSBR) D.non- homologous end joining (NHEJ) E. Synthesis-dependent strand annealing(SDSA)arrow_forwardWhich of the following molecules helps relieve the tension of unwinding parental DNA strands, by breaking DNA and rejoining it before it is replicated? a. Primase b. Single-stranded binding proteins c. Helicase d. Topoisomerasearrow_forward
- 1. A.) Deletion mutation is a loss of a single base by damage. B.) Point mutation is when a nucleotide is paired with a wrong nucleotide during RNA replication. a. Statement A is correct b. Statement B is correct c. Both A and B are correct d. Both A and B are incorrect Answer: 2. This is a process that produces a change in the structure of the DNA by forming adenine rather than guanine. a. Reverse transcription of guanine b. Alkylation of the 06-Guanine c. Reverse translation of guanine d. Methylation of guanine bases Answer: 3. This type of DNA repair happens when you are removing a single damaged base of DNA strand. a. Nucleotide repair b. Base excision repair c. Strand break repair d. Base nucleotide replacement Answer:arrow_forwardThe general excision repair pathway for DNA repair has the following order A. endonuclease cuts → DNA ligase removes → endonuclease removes → DNA ligase B. DNA ligase → DNA polymerase → helicase or endonuclease removes → endonuclease cuts C. endonuclease cuts → helicase or endonuclease removes → DNA polymerase → DNA ligase D. endonuclease cuts → DNA polymerase repairs → helicase opens up → DNA ligasearrow_forwardDefine the following terms: a. transfection b. replicative transposition c. composite transposition d. retrotransposon e. insertional elementarrow_forward
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