Concept explainers
The cl gene that encodes the λ repressor has two promoters designated
a.
b.
c.
d.
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Chapter 18 Solutions
Genetics: Analysis and Principles
- If there is a mutation in importin that prevents it from interacting with the NLS of cargo proteins, what affect, if any, would this have on the UPR (unfolded protein response). A. Ran-GEF would bind to the importin promoting cargo entry into the nucleus and transcription of UPR response genes. B. Gene regulatory protein would not be imported into the nucleus thus preventing transcription of UPR response genes C. MRNA would not be imported into the nucleus thus preventing transcription of UPR response genes D. Ran-GTP would not be imported to the nucleus thus preventing transcription of UPR response genes E. No effect, these are completely unrelated processes.arrow_forwardTumor cells from a person with leukemia have been analyzed to determine which oncogene is involved in the transformation. After partial sequencing of the gene, the predicted gene product is identified as a tyrosine kinase. Which of the following proteins would most likely be encoded by an oncogene and exhibit tyrosine kinase activity? A. Nuclear transcriptional activator B. Epidermal growth factor C. Membrane-associated G protein D. Platelet-derived growth factor E. Growth factor receptorarrow_forwardWhich ONE of the following is TRUE concerning the so‐called Philadelphia chromosome? Select one: A.It results in loss of BCR serine‐threonine kinase activity B.It leads to generation of a fusion protein with constitutively active tyrosine kinase activity C.It results from a t(8;21) translocation D.Overexpression of the ABL1 gene results from a translocation that brings a strong gene promoter close to the ABL1 genearrow_forward
- After the initial Actualization of the Cit+ phenotype, there was another alteration to the A-3 genome that resulted in increased growth (e.g. Refinement). What explained the increase in growth rate in response to Refinement? A. Increase number of transporters localized to the plasma membrane. B. Increased ability to metabolize glucose. C. Increased citric acid cycle activity. D. Altered promoter activity resulting in constitutive gene expression.arrow_forwardWhen iron is scarce, some bacteria can stop synthesis of all enzymes that require iron (Fe3+), such as superoxide dismutase (SOD). Which of the following accurately describes a mechanism for this regulation? Mark all that apply. A. Regulation occurs by an inducible operon B. When absent, the lack of iron causes the repressor to deactivate and block the promoter region for these genes C. Regulation occurs by a repressible operon D. When present, iron binds and activates the repressor proteinarrow_forwardWhat is an example where p27 kip1 can remain in the nucleus performing its inhibitory effect? A. When p27 kip1 mutant with Threonine to Alanine substitution is expressed. B. When a constitutively active Akt/PKB is expressed and interact with wild type p27 kip1 C. When a dominant-negative Akt/PKB is expressed D. A and C are correct.arrow_forward
- This data shows the efficacy of different treatments on the survival rates of patients with glioblastomas, as well as methylated, and on methylated MGMT promoters. A. Explain the trends in the figure B. Relate MGMT methylation to the central dogma/flow of genetic information, and how genes are expressed. arrow_forwardA particular drug inhibits the protein kinase that is responsible for phosphorylating the CREB protein. How would this drug affect the following events? A. The ability of the CREB protein to bind to CREs B. The ability of extracellular hormones to enhance cAMP levels C. The ability of the CREB protein to stimulate transcription D. The ability of the CREB protein to dimerizearrow_forwardWhich of the following consequences of mutations would likely to be associated with an increased cancer risk? (select all that apply)? A. Truncation of the EGF receptor B. Constitutive activation of K-Ras C. Amplification of myc D. Truncation of H-Ras due to a premature stop codon E. Amplification of ErbB2arrow_forward
- When the antigen-presenting cells binds to the T-cell, it will cause the T-cell to increase the amount of a protein called perforin, which is secreted to kill nearby cells. Which of these could INCREASE the amount of a functional perforin proteins produced? a. Increased methylation of DNA near the site of the gene b. Increased binding of a repressor, that decreases the binding affinity between TFIID and DNA c. Increased production of a small RNA that is complementary to perforin mRNA d. Increased O-linked glycoslyation of perforin proteins in the Golgiarrow_forwardThere is Hyaluronic acid synthesis occuring in Group X Strep and it is controlled by an operon with 3 genes, called hasXYZ. Based on the 3-line diagram model, a. How many ribosome binding sites are there for the protein? b. How many promoters are there for the genes? c. How many start codons are there for the protein? d. How many RNA Polymerase binding locations are there for the genes? e. How many proteins will be fully functional? f. How many mRNA strands are made?arrow_forwardA mutation in the operator region of the trp operon can prevent the trp repressor from binding to this operator. When these mutant cells are placed in a solution containing chicken broth, which of the following happens? a. Tryptophan would bind to the repressor. b. The Repressor would bind to the operator irrespective of the presence of amino acids in the environment. c. The transcription of the trip operon would be inhibited. d. The transcription of the repressor protein is inhibitedarrow_forward
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