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This data shows the efficacy of different treatments on the survival rates of patients with glioblastomas, as well as methylated, and on methylated MGMT promoters. A. Explain the trends in the figure B. Relate MGMT methylation to the central dogma/flow of genetic information, and how genes are expressed. 

This data shows the efficacy of different treatments on the survival rates of patients with glioblastomas, as well as methylated, and on methylated MGMT promoters. A. Explain the trends in the figure B. Relate MGMT methylation to the central dogma/flow of genetic information, and how genes are expressed. 

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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This data shows the efficacy of different treatments on the survival rates of patients with glioblastomas, as well as methylated, and on methylated MGMT promoters. A. Explain the trends in the figure B. Relate MGMT methylation to the central dogma/flow of genetic information, and how genes are expressed. 
- Unmethylated, radiotherapy Unmethylated, radiotherapy plus temozolomide Methylated, radiotherapy Methylated, radiotherapy plus temozolomide Probability of Overall Survival (%) 100- 90- 80- 70- 60- 50- 40- 30- 20- 10- 0- 0 6 12 18 001 A P=0.007 P=0.06 4 24 soll un Months 30 36 7 42 I Figure 2. Treatment of Glioblastoma as Related to Overall Survival. From The New England Journal of Medicine, Hegi, M.E. et al., MGMT gene silencing and benefit from temozolomide in glioblastoma, 352, 997-1003, Figure 3A. Copyright © 2005 Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.
Transcribed Image Text:- Unmethylated, radiotherapy Unmethylated, radiotherapy plus temozolomide Methylated, radiotherapy Methylated, radiotherapy plus temozolomide Probability of Overall Survival (%) 100- 90- 80- 70- 60- 50- 40- 30- 20- 10- 0- 0 6 12 18 001 A P=0.007 P=0.06 4 24 soll un Months 30 36 7 42 I Figure 2. Treatment of Glioblastoma as Related to Overall Survival. From The New England Journal of Medicine, Hegi, M.E. et al., MGMT gene silencing and benefit from temozolomide in glioblastoma, 352, 997-1003, Figure 3A. Copyright © 2005 Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.
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