Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 18, Problem 5EQ
Summary Introduction
To review:
The mechanism of the drugs that affect spike glycoproteins in the viral envelope to combat human viral disease.
Introduction:
Virus is an infectious particle that is composed of
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‘’Viruses cannot be grown in standard microbiological culture such as broth and agar. They need to be cultured in the presence of a suitable host such as prokaryotic cells (easiest to grow in the lab), plants and animals because they are unable to reproduce independently in living cells’’.2.2 What are the changes that are brought by a virus to a cell? In your response, make reference to the cytopathic effect (CPE).
Researchers studying the SARS-CoV-2 virus, also known as COVID-19, have found that the
virus is able to circumvent its host cell's normal defenses by leaving the cell via its lyso-
somes rather than its normal secretory vesicles, as illustrated in the figure below.
endoplasmic
reticulum
nucleus
disrupted
lysosomal functions
Entry and egress of the SARS-CoV-2 virus
A
Golgi complex
Which of the following best explains their findings?
B
lysosome
(deacidified)
С
lysosome
(acidified)
B-coronavirus
normal
biosynthetic
pathway
egress via
lysosomal
trafficking
SARS-CoV-2 inhibits lysosomes of its host cells by decreasing the pH within them.
SARS-CoV-2 activates lysosomes of its host cells by decreasing the pH within them.
SARS-CoV-2 activates lysosomes of its host cells by increasing the pH within them.
D SARS-CoV-2 inhibits lysosomes of its host cells by increasing the pH within them.
Explain the role receptor-mediated endocytosis (RME) plays in virus replication (lytic cycle).
Chapter 18 Solutions
Genetics: Analysis and Principles
Ch. 18.1 - 1. What is a common feature found in all viruses?...Ch. 18.1 - 2. Viral genomes can be
a. DNA or RNA.
b....Ch. 18.2 - Prob. 1COMQCh. 18.2 - Prob. 2COMQCh. 18.3 - A mutation in phage results in 10-fold greater...Ch. 18.3 - 2. The cl gene that encodes the λ repressor has...Ch. 18.4 - A viral protein that is needed to make HIV DNA is...Ch. 18.4 - Prob. 2COMQCh. 18.4 - After HIV components are made, what is the correct...Ch. 18 - 1. Discuss why viruses are considered nonliving.
Ch. 18 - What structural features are common to all...Ch. 18 - 3. What are the similarities and differences among...Ch. 18 - Prob. 4CONQCh. 18 - Prob. 5CONQCh. 18 - Prob. 6CONQCh. 18 - Prob. 7CONQCh. 18 - Prob. 8CONQCh. 18 - Prob. 9CONQCh. 18 - Prob. 10CONQCh. 18 - 11. What is a prophage, a provirus, and an...Ch. 18 - Prob. 12CONQCh. 18 - Prob. 13CONQCh. 18 - 14. With regard to promoting the lytic or...Ch. 18 - 15. How do therepressor and the cro protein affect...Ch. 18 - Prob. 16CONQCh. 18 - Figure 18.11 shows a genetic switch that controls...Ch. 18 - Prob. 18CONQCh. 18 - Prob. 19CONQCh. 18 - Explain the role of RNase H (a component of...Ch. 18 - Prob. 21CONQCh. 18 - Prob. 22CONQCh. 18 - Prob. 23CONQCh. 18 - 24. Compare and contrast the roles of fully...Ch. 18 - 25. Describe the role of the Gag polyprotein...Ch. 18 - Prob. 26CONQCh. 18 - Prob. 27CONQCh. 18 - 1. Discuss how researchers determined that TMV is...Ch. 18 - Prob. 2EQCh. 18 - What is a reconstituted virus?Ch. 18 - Following the infection of healthy tobacco leaves...Ch. 18 - Prob. 5EQCh. 18 - Prob. 6EQCh. 18 - A researcher identified a mutation in PR of phage ...Ch. 18 - Experimentally, when an E. coli bacterium already...Ch. 18 - 9. A bacterium is exposed to a drug that inhibits...Ch. 18 - This question combines your knowledge of bacterial...Ch. 18 - Prob. 1QSDCCh. 18 - 2. Certain environmental conditions such as...Ch. 18 - 3. Browse the Internet to determine the drugs that...
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- An antimicrobial drug binds to the HIV reverse transcriptase enzyme, preventing it from working. Which of the following is true of this drug? It would inhibit early replication steps of some viruses, but not affect normal eukaryotic cell activity. It would directly interfere with translation of some viral proteins and some eukaryotic proteins. It would block assembly/maturation steps of some viruses, and interfere with translation in eukaryotic cells. It would interfere with release of newly formed viruses from a host cell, but not affect eukaryotic cells. It would interfere with protein synthesis in bacteria, but not affect eukaryotic ribosomes. It would interfere with mRNA transcription in bacteria and viruses, but not affect eukaryotic transcription.arrow_forwardWhich of the following highly contagious viruses is a single-stranded ribonucleic acid (RNA) virus with a helical capsid and envelope and is transmitted by coming in contact with respiratory secretions? "This is a highly contagious respiratory illness transmitted when an infected person coughs or sneezes virus particles into the air," the health department said in a written statement. "It's so contagious that if one person is sick and spreading measles, nine out of 10 people around them who aren't immune will get it, too." Group of answer choices a. Measles b. Parvovirus c. Coxsackie virus A d. Rhinovirusarrow_forwardExplain how antiviral genes in your DNA get activated ? Include the names of all molecules involved and how they work in the fight against a viral infection.arrow_forward
- Considering that each virus must bind to a specific cell surface receptor for attachment, explain how you would create a drug that prevents viral attachment.arrow_forwardRhinovirus, the most common cause of colds, do not have a lipid envelope. Compared to enveloped viruses these and other nonenveloped viruses tend to remain infectious outside the body longer, are more likely to be spread by contact with surfaces, and are likely to be rendered harmless by exposure to hand sanitizer or hand washing. Explain how the lack of an envelope could contribute to these characteristics.arrow_forwardIn electron micrographs of HSV infection, it can be seen that the intact virus initially reacts with cell-surface proteoglycans, then with specific receptors. This is later followed by viral capsids docking with nuclear pores. Afterward, the capsids go from being full to being "empty." Which of the following statements best fits these observations? The viral envelope is not required for infectivity, since the envelope does not enter the nucleus. The viral envelope mediates entry into the cell, the capsid mediates entry into the nuclear membrane, and the genome is all that enters the nucleus. Only the genetic material of the virus is involved in the cell's infectivity, and is injected into the host cell like the genome of a phage. Viral capsids are needed for the cell to become infected; since the full capsids enter the nucleus.arrow_forward
- Rhinoviruses, the most common cause of colds, do not have a lipid envelope. Compared to enveloped viruses, these and other nonenveloped viruses tend to remain infectious outside the body longer, are more likely to be spread by contact with surfaces, and are less likely to be rendered harmless by exposure to hand sanitizer or hand washing. Explain how the lack of an envelope could contribute to these characteristics.arrow_forwardThe dUTPase enzyme is used by the African swine fever virus to repair its own DNA, as the cells the virus infects in swine do not express the dUTPase protein. Which of the following is a reasonable explanation for the role of the dUTPase in the virus lifecycle? Explain your choice in 25 words or less. The dUTPase is necessary to remove dUTP from the viral genome, as uracil should not be present in DNA The dUTPase is necessary to remove dUTP from the viral genome, as uridine cannot correctly base pair with adenine-containing bases The dUTPase is necessary to remove dUTP from the viral genome, as uridine has the wrong sugar component for building DNA More than one of the above answers is correct None of the above answers is correctarrow_forwardThe viral genome needs to get to the nucleus for the virus that replicates in the nucleus. In other words, the viral nucleocapsid has to overcome two barriers (i.e., plasma membrane and nuclear membrane). Compare and contrast the mechanisms by which the viruses penetrate the two membranes.arrow_forward
- viral genome needs to get to the nucleus for the virus that replicates in the nucleus. the viral nucleocapsid has to pass two barriers (i.e., plasma membrane and nuclear membrane). Compare and contrast the mechanisms by which the viruses penetrate the two membranes.arrow_forwardThe 5'-Cap on viral MRNA plays a critical role in: Maturation and stability of the MRNA Translocation to the nucleus Association with the endoplasmic reticulum Packaging of mRNA into nucleocapsidarrow_forwardWhen a virus infects eukaryotic cells, one fate of the cell is lysis. List and briefly describe two other potential fates.arrow_forward
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What Is A Virus ? ; Author: Peekaboo Kidz;https://www.youtube.com/watch?v=YS7vsBgWszI;License: Standard YouTube License, CC-BY