Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 16, Problem 9CONQ
In general, explain how epigenetic modifications are an important mechanism for developmental changes that lead to specialized body parts and cell types. How do the trithorax and polycomb group complexes participate in this process?
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In general, explain how epigenetic modifications are an important mechanism for developmental changes that lead to specialized body parts and cell types. How do the trithorax and polycomb group complexes participate in thisprocess?
Describe the molecular steps by which polycomb groups cause epigenetic gene silencing.
What condition must be fulfilled in order for histone modification to be considered an epigenetic phenomenon? Does DNA methylation meet that criterion? Explain.
Chapter 16 Solutions
Genetics: Analysis and Principles
Ch. 16.1 - Which of the following are examples of molecular...Ch. 16.1 - 2. An epigenetic modification to a specific gene...Ch. 16.1 - Prob. 3COMQCh. 16.1 - Epigenetic changes may a. be programmed during...Ch. 16.2 - 1. For the Igf2 gene, where do de novo methylation...Ch. 16.2 - 2. For XCI to occur, where are the Xist and Tsix...Ch. 16.2 - 3. Which of the following possibilities could...Ch. 16.3 - 1. Which of the following statements about...Ch. 16.3 - The effects of paramutation may vary with regard...Ch. 16.4 - 1. When mice carrying theallele exhibit a darker...
Ch. 16.4 - 2. If the VIN3 gene had a loss-of-function...Ch. 16.5 - Prob. 1COMQCh. 16.5 - Prob. 2COMQCh. 16 - Prob. 1CONQCh. 16 - List and briefly describe five types of molecular...Ch. 16 - Prob. 3CONQCh. 16 - What is the key difference between cis and...Ch. 16 - Prob. 5CONQCh. 16 - Prob. 6CONQCh. 16 - 7. Outline the molecular steps in the process of...Ch. 16 - Prob. 8CONQCh. 16 - 9. In general, explain how epigenetic...Ch. 16 - 10. What are the contrasting roles of trithorax...Ch. 16 - Describe the molecular steps by which polycomb...Ch. 16 - Prob. 12CONQCh. 16 - Using coat color in mice and the development of...Ch. 16 - How can environmental agents that do not cause...Ch. 16 - Prob. 15CONQCh. 16 - Prob. 16CONQCh. 16 - Explain how the VIN3/PRC2 complex specifically...Ch. 16 - Prob. 1EQCh. 16 - In the experiments described in Figure 16.8,...Ch. 16 - Prob. 3EQCh. 16 - A research study indicated that an agent in...Ch. 16 - Lets suppose you were interested in developing...Ch. 16 - Prob. 6EQCh. 16 - Prob. 7EQCh. 16 - 2. Discuss the similarities and differences of...
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- (1)What is epigenetics? What is the role of methylation in epigenetics? At what level (Replication, Transcription, Translation) does epigenetics act? (2) What is the effect of splicing on RNA? What is the purpose of alternate splicing? (3) If a DNA sequence is 5' TCC GGT CAT 3' what are the RNA and protein sequences that can be made from the strand? Use this codon table บบบา UUC UUA UUG CUU CUC CUA CUG AUU AUC AUA AUG a GUU GUC GUA GUG. Phe Leu Leu lle Met Val UCU UCC UCA UCG CCU CCC CCA CCG ACU ACC ACA ACG GCU GCC GCA GCG Ser Pro Thr Ala UAU UAC UAA UAG CAU č} CAC CAA CAG AAU AAC AAA AAG GAU GAC GAG} Tyr Stop His Gln Asn Lys Asp Glu UGU UGC Cys UGA Stop UGG Trp CGU CGC CGA CGG AGU AGC AGA à} AGG GGU GGC GGA GGG Arg Ser Arg Gly 4. Normal yeast cells can survive on a diet of sugars, a few simple salts and one vitamin. They can make all of their amino acids and other vitamins using what can be found in their diet. You identify a mutant strain that can only survive if given alanine, which…arrow_forward"Tobacco smoking triggers a large number of somaticmutations and epigenetic changes". Define about this ?arrow_forwardGive the examples of epigenetic modifications ?arrow_forward
- Define the epigenetic mechanisms - reversible modification of DNA by the addition or removal of methyl groups ?arrow_forwardWhat are the mechanisms in which DNA is used to generate protein. What are the key points in the process and major differences between the mechanism in prokaryotic and eukaryotic cells Although the DNA in our genes is considered to be the heritable genetic material, other factors, including the environment are considered to play an important role in the activity and expression of those genes. Summarize the role that epigenetics & developmental epigenetics play in health & disease.arrow_forwardWhat is the result when the core histones are acetylated via histone acetyltransferase? A) The result depends on which histone is modified. B) The DNA becomes more tightly associated with the core. O C) The DNA becomes less associated with the core. This modification has no effect on how tightly associated DNA will become with the core.arrow_forward
- List and briefly describe five types of molecular mechanisms thatmay underlie epigenetic gene regulation.arrow_forwardAlthough each cell in your body contains the same set of genes, the genes that are “turned on” differ depending on the type of cell. What signals different genes to be “turned on” or transcribed in different cells? What types of behaviours or environmental circumstances can lead to changes in an individual’s epigenome? Explain. 3. Explain how changes in your epigenome can alter the DNA of your future children before they are even born. 4.) Explain TWO implications of these findings for society. (Hint: think big! Implications for how disease is transmitted, intergenerational trauma, the cycle of poverty, etc.)arrow_forwardWhat are the contrasting roles of trithorax and polycomb group complexes during development in animals and plants?arrow_forward
- DNA methylation is considered an epigenetic phenomenon because the pattern of methylation can be inherited. Briefly discuss the question of whether histone modifications in chromatin represent an epigenetic phenomenon.arrow_forwardATM is a kinase that phosphorylates histone H2AX in response to double-stranded DNA breaks. Which of the following scenarios would most quickly regulate ATM activity in the cell? a) Adding silencing methyl groups to cytosines in the Atm gene b) Modifying the histone code for the Atm gene c) Increasing expression of a miRNA specific for the Atm mRNA d) Activating an E3 ubiquitin ligase specific for the ATM proteinarrow_forward(a) How does the duplication of individual genes occur? (b) individual that inherit a genetic condition known as xeroderma pigmentosum exhibit an extreme sensitivity to sunlight exposure and often develop skin cancer by the age of 10. What repair pathway is most likely disrupted as a result of such mutation? Explain why?arrow_forward
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