Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 16, Problem 5CONQ
Summary Introduction
To review:
The process of methylation of DNA (deoxyribonucleic acid) and the effect of formation of DNA loop in controlling the expression of Igf2 gene. The imprinting of this gene such that, only the paternal copy expresses in the offspring.
Introduction:
Epigenetic mechanism helps control the expression of genes. The epigeneticeffect can be seen through histone modifications and DNA methylation. This changes the functions of DNA and modifies gene functions.
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Explain how DNA methylation could be used to regulate gene expression in a tissue-specific way. When and where would de novo methylation occur, and when would demethylation occur? What would occur in the cells that give rise to eggs and sperm?
Describe the mechanism of genomic imprinting of the Igf2 gene in mammals.
Explain how methylation of cytosine nucleotides can affect gene expression in one way.
Explain how methylation of histone proteins can affect gene expression in one way.
Chapter 16 Solutions
Genetics: Analysis and Principles
Ch. 16.1 - Which of the following are examples of molecular...Ch. 16.1 - 2. An epigenetic modification to a specific gene...Ch. 16.1 - Prob. 3COMQCh. 16.1 - Epigenetic changes may a. be programmed during...Ch. 16.2 - 1. For the Igf2 gene, where do de novo methylation...Ch. 16.2 - 2. For XCI to occur, where are the Xist and Tsix...Ch. 16.2 - 3. Which of the following possibilities could...Ch. 16.3 - 1. Which of the following statements about...Ch. 16.3 - The effects of paramutation may vary with regard...Ch. 16.4 - 1. When mice carrying theallele exhibit a darker...
Ch. 16.4 - 2. If the VIN3 gene had a loss-of-function...Ch. 16.5 - Prob. 1COMQCh. 16.5 - Prob. 2COMQCh. 16 - Prob. 1CONQCh. 16 - List and briefly describe five types of molecular...Ch. 16 - Prob. 3CONQCh. 16 - What is the key difference between cis and...Ch. 16 - Prob. 5CONQCh. 16 - Prob. 6CONQCh. 16 - 7. Outline the molecular steps in the process of...Ch. 16 - Prob. 8CONQCh. 16 - 9. In general, explain how epigenetic...Ch. 16 - 10. What are the contrasting roles of trithorax...Ch. 16 - Describe the molecular steps by which polycomb...Ch. 16 - Prob. 12CONQCh. 16 - Using coat color in mice and the development of...Ch. 16 - How can environmental agents that do not cause...Ch. 16 - Prob. 15CONQCh. 16 - Prob. 16CONQCh. 16 - Explain how the VIN3/PRC2 complex specifically...Ch. 16 - Prob. 1EQCh. 16 - In the experiments described in Figure 16.8,...Ch. 16 - Prob. 3EQCh. 16 - A research study indicated that an agent in...Ch. 16 - Lets suppose you were interested in developing...Ch. 16 - Prob. 6EQCh. 16 - Prob. 7EQCh. 16 - 2. Discuss the similarities and differences of...
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- Explain how DNA methylation can regulate gene expression in a tissue-specific way. When and where would de novo methylation occur,and when would demethylation occur? What would occur in the cellsthat give rise to eggs and sperm?arrow_forwardWhat is a CpG island? Where would you expect one to be located? How does the methylation of CpG islands affect gene expression?arrow_forwardDescribe two different types of pre-transcriptional control of gene expression? Give an example of each type.arrow_forward
- Describe the role of DNA methylation in gene expression in mammalian cells.arrow_forwardList and briefly describe five types of molecular mechanisms thatmay underlie epigenetic gene regulation.arrow_forwardIn the gene in the fruit fly (Drosophila) called antennepedia. It controls the formation of which structures? What happens when it is mutated?arrow_forward
- Explain what a morphogen is, and describe how it exerts its effects. What do you expect will happen when a morphogen is expressed in the wrong place in an embryo? List five examples of morphogens that function in Drosophila.arrow_forwardIn general, explain how epigenetic modifications are an important mechanism for developmental changes that lead to specialized body parts and cell types. How do the protein complexes called the trithorax and polycomb groups participate in this process?arrow_forwardHow do we know that expression of the information encoded in DNA involves an RNA intermediate?arrow_forward
- Progesterone is a steroid hormone (also described as a ligand) that prepares the body for pregnancy. It binds to the progesterone receptor (PR) protein in the cytoplasm of various cells. Ligand bound PR acts as a transcriptional activator, binds to the DNA in the promoter region of several genes and leads to transcriptional activation of these genes. Which of the following statements must be true for the PR protein? O Ligand binding to the PR results in a conformational change in the primary structure of the protein The domain/region of the PR protein that interacts with the DNA, has basic amino acids Ligand binding to the PR results in a conformational change in the tertiary structure of the protein The domain/region of the PR protein that interacts with the DNA, has acidic amino acidsarrow_forwardA mutation occurs in the Drosophila doublesex gene that prevents Tra from binding to the dsx RNA transcript. What would be the consequences of this mutation for Dsx protein expression in males? In females?arrow_forwardDefine the epigenetic mechanisms - regulation of gene expression by noncoding RNA molecules ?arrow_forward
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