Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 16, Problem 11CONQ
Describe the molecular steps by which polycomb group complexes cause epigenetic gene silencing.
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Describe the molecular steps by which polycomb group complexescause epigenetic gene silencing.
In general, explain how epigenetic modifications are an important mechanism for developmental changes that lead to specialized body parts and cell types. How do the protein complexes called the trithorax and polycomb groups participate in this process?
In general, explain how epigenetic modifications are an important mechanism for developmental changes that lead to specialized body parts and cell types. How do the trithorax and polycomb group complexes participate in thisprocess?
Chapter 16 Solutions
Genetics: Analysis and Principles
Ch. 16.1 - Which of the following are examples of molecular...Ch. 16.1 - 2. An epigenetic modification to a specific gene...Ch. 16.1 - Prob. 3COMQCh. 16.1 - Epigenetic changes may a. be programmed during...Ch. 16.2 - 1. For the Igf2 gene, where do de novo methylation...Ch. 16.2 - 2. For XCI to occur, where are the Xist and Tsix...Ch. 16.2 - 3. Which of the following possibilities could...Ch. 16.3 - 1. Which of the following statements about...Ch. 16.3 - The effects of paramutation may vary with regard...Ch. 16.4 - 1. When mice carrying theallele exhibit a darker...
Ch. 16.4 - 2. If the VIN3 gene had a loss-of-function...Ch. 16.5 - Prob. 1COMQCh. 16.5 - Prob. 2COMQCh. 16 - Prob. 1CONQCh. 16 - List and briefly describe five types of molecular...Ch. 16 - Prob. 3CONQCh. 16 - What is the key difference between cis and...Ch. 16 - Prob. 5CONQCh. 16 - Prob. 6CONQCh. 16 - 7. Outline the molecular steps in the process of...Ch. 16 - Prob. 8CONQCh. 16 - 9. In general, explain how epigenetic...Ch. 16 - 10. What are the contrasting roles of trithorax...Ch. 16 - Describe the molecular steps by which polycomb...Ch. 16 - Prob. 12CONQCh. 16 - Using coat color in mice and the development of...Ch. 16 - How can environmental agents that do not cause...Ch. 16 - Prob. 15CONQCh. 16 - Prob. 16CONQCh. 16 - Explain how the VIN3/PRC2 complex specifically...Ch. 16 - Prob. 1EQCh. 16 - In the experiments described in Figure 16.8,...Ch. 16 - Prob. 3EQCh. 16 - A research study indicated that an agent in...Ch. 16 - Lets suppose you were interested in developing...Ch. 16 - Prob. 6EQCh. 16 - Prob. 7EQCh. 16 - 2. Discuss the similarities and differences of...
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- List and briefly describe five types of molecular mechanisms thatmay underlie epigenetic gene regulation.arrow_forwardATM is a kinase that phosphorylates histone H2AX in response to double-stranded DNA breaks. Which of the following scenarios would most quickly regulate ATM activity in the cell? a) Adding silencing methyl groups to cytosines in the Atm gene b) Modifying the histone code for the Atm gene c) Increasing expression of a miRNA specific for the Atm mRNA d) Activating an E3 ubiquitin ligase specific for the ATM proteinarrow_forwardDNA methylation is considered an epigenetic phenomenon because the pattern of methylation can be inherited. Briefly discuss the question of whether histone modifications in chromatin represent an epigenetic phenomenon.arrow_forward
- Describe the function of telomere repeat-binding factors.arrow_forward"Tobacco smoking triggers a large number of somaticmutations and epigenetic changes". Define about this ?arrow_forwardA gene, which we will call gene C, can be epigenetically modified in such a way that its expression in some cells is permanently silenced. Describe how you could conduct cell-fusion experiments to determine if a cis- or a trans-epigenetic mechanism is responsible for maintaining the silencing of gene C.arrow_forward
- What is the result when the core histones are acetylated via histone acetyltransferase? A) The result depends on which histone is modified. B) The DNA becomes more tightly associated with the core. O C) The DNA becomes less associated with the core. This modification has no effect on how tightly associated DNA will become with the core.arrow_forwardhttps://ny.pbslearningmedia.org/resource/biot09.sci.life.gen.epigenetics/epigenetics/ Explain DNA methylation. How does this process influence cellular function?arrow_forwardDescribe how chromatin remodeling complexes allowgene expression to occur.arrow_forward
- What are epigenetic marks? Which are associated withheterochromatin? How are epigenetic marks thought tobe responsible for determining chromatin structure?arrow_forwardOutline the types of molecular changes that underlie epigeneticgene regulation.arrow_forwardDesign a transcriptional circuit that regulates the expression of β-galactosidase in a eukaryoticcell, such that the enzyme is produced in the presence of lactose and repressed in the absenceof lactose. Use at least one of the following elements: histone acetyltransferase, histonedeacetylase, chromatin remodeling complexarrow_forward
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